Chappell has acted in numerous roles in New Zealand, including Gloss, Shortland Street, Hercules: The Legendary Journeys, and City Life. Starting in 2000, Chappell played Claire McLeod in the Australian show McLeod's Daughters. For this portrayal, she won a Most Popular Actress Logie Award and was nominated for a Silver Logie in 2003. She moved on from the show in 2003, when her character was killed in a car accident.
She has also appeared in the third installment of Small Claims, 'The Reunion', and starred in Stingers as Megan Walsh (Season 8).
Lisa starred in a stage adaptation of Educating Rita in 2007, which toured Australia. She also stars in the Australian film Coffin Rock.
Chappell's current focus is her music career. Her debut album, When Then Is Now, was released on 1 May 2006. It was a commercial flop. She did some minor touring in Australia and New Zealand to support the release of this album.
In March 2004, Lisa became an ambassador for The Humor Foundation. She wanted to help raise money to keep The Clown Doctors in Australian hospitals. She has also written a children's book, in which she collaborated with her husband Chris to produce, which was illustrated by Chris.
Lisa married her husband Chris Taylor in 2001 after they met at her co-star Rachael Carpani's 21st birthday party, they later divorced in 2005. She made the decision to become a vegetarian after joining the cast of McLeod's Daughters. Lisa also supports donating blood and encourages everyone to give blood. She loves to write lyrics and other texts.