ACE inhibitor and thiazide combination

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An ACE inhibitor and thiazide combination is a drug combination used to treat hypertension. They are given by oral administration.

Examples[edit]

  • Enalapril/hydrochlorothiazide (trade name Enalapril comp), wherein enalapril is the ACE inhibitor and hydrochlorothiazide is the thiazide.
Quinapril/hydrochlorothiazide
Combination of
Quinapril Angiotensin converting enzyme inhibitor
Hydrochlorothiazide Thiazide diuretic
Clinical data
Trade names Accuretic
AHFS/Drugs.com Multum Consumer Information
Pregnancy
category
  • US: D (Evidence of risk)
Legal status
Legal status
Identifiers
ATC code C09BA06 (WHO)
ChemSpider 30797396
Lisinopril/hydrochlorothiazide
Combination of
Lisinopril ACE inhibitor
Hydrochlorothiazide Thiazide diuretic
Clinical data
MedlinePlus a601070
Pregnancy
category
  • US: D (Evidence of risk)
Routes of
administration
Oral
Legal status
Legal status
  • ℞ (Prescription only)
Identifiers
ATC code C09BA03 (WHO)
  (verify)

Fosinopril/hydrochlorothiazide[edit]

Fosinopril/hydrochlorothiazide
Combination of
Fosinopril Angiotensin converting enzyme inhibitor
Hydrochlorothiazide Thiazide diuretic
Clinical data
Trade names Monopril HCT
Pregnancy
category
  • C (1st trimester); D (2nd & 3rd trimesters)
Routes of
administration
Oral
Legal status
Legal status
  • ℞ (Prescription only)
Identifiers
ATC code C09BA09 (WHO)

Fosinopril/hydrochlorothiazide (trade name Monopril HCT) has a boxed warning about its significant risk to cause fetal/neonatal morbidity and mortality when being used during pregnancy (2nd and 3rd trimesters).[4]

FDA modified its labeling on February, 2009 to include a precaution of drug interaction with gold. "Nitritoid reactions (symptoms include facial flushing, nausea, vomiting and hypotension) have been reported rarely in patients on therapy with injectable gold (sodium aurothiomalate) and concomitant ACE inhibitor therapy including Monopril/Monopril HCT."[5]

See also[edit]

References[edit]