List of 5α-reductase inhibitors

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This is a list of 5α-reductase inhibitors (5α-RIs), drugs which inhibit one or more isoforms of the enzyme 5α-reductase. This enzyme is responsible for the conversion of the androgen hormone testosterone into the more potent dihydrotestosterone (DHT) and is essential for the production of neurosteroids like allopregnanolone, tetrahydrodeoxycorticosterone (THDOC), and 3α-androstanediol from progesterone, deoxycorticosterone, and DHT, respectively. 5α-Reductase inhibitors have medical applications in the treatment of benign prostatic hyperplasia, androgenic alopecia (pattern hair loss), and hirsutism (excessive hair growth).

Pharmaceutical drugs[edit]

5α-RIs that are used in medicine include the following:

Experimental drugs[edit]

5α-RIs that were under development for potential clinical use but were never marketed or are used in research include the following:

Herbs and other inhibitors[edit]

Many plants, as well as their associated phytochemical constituents, have inhibitory effects on 5α-reductase.[9] In addition, many of these compounds are also phytoestrogens.[10] Examples include the following:

These supplements have limited testing in human clinical trials, and their potential for the treatment of BPH, androgenic alopecia, and related conditions is unknown.


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