List of JWH cannabinoids

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The John W. Huffman research group at Clemson University synthesized over 450 cannabinoids. Some of those are:

Cannabinoids and their Ki values
Name Class Ki at CB1 [nM] Ki at CB2 [nM] Selectivity CLogP Structure
JWH-004 Naphthoylindole 48 ± 13 4 ± 1.5 CB2 (12x) 6.43 JWH-004.svg
JWH-007 Naphthoylindole 9.5 ± 4.5 2.9 ± 2.6 CB2 (3.3x) 6.01 JWH-007.svg
JWH-009 Naphthoylindole >10000 141 ± 14 CB2 (>70x) 6.85 JWH-009.svg
JWH-011 Naphthoylindole 6.75 JWH-011.svg
JWH-015 Naphthoylindole 383 13.8 CB2 (28x) 5.18 JWH 015.svg
JWH-016 Naphthoylindole 22 ± 1.5 4.3 ± 1.6 CB2 (5.1x) 5.6 JWH-016.svg
JWH-018 Naphthoylindole 9 ± 5 2.9 ± 2.6 CB2 (3.1x) 5.68 JWH 018.svg
JWH-019 Naphthoylindole 9.8 ± 2 5.55 ± 2 CB2 (1.77x) 6.09 JWH 019.svg
JWH-020 Naphthoylindole 128 ± 17 205 ± 20 CB1 (1.6x) 6.51 JWH-020.svg
JWH-030 Naphthoylpyrrole 87 320 ± 127 CB1 (3.7x) 4.62 JWH 030.svg
JWH-031 Naphthoylpyrrole 399 ± 109 5.04 JWH-031.svg
JWH-032 Naphthoylpyrrole 3.79 JWH-032.svg
JWH-033 Naphthoylpyrrole 4.21 JWH-033.svg
JWH-036 Naphthoylpyrrole 309 ± 11
JWH-042[1] Naphthoylindole >10000 5050 ± 192 CB2 4.35 JWH-042.svg
JWH-043[1] Naphthoylindole 1180 ± 44 964 ± 242 CB2 (1.2x) 4.69 JWH-043.svg
JWH-044 Naphthoylpyrrole 2.96 JWH-044.svg
JWH-045 Naphthoylpyrrole 3.3 JWH-045.svg
JWH-046[1] Naphthoylindole 343 ± 38 16.3 ± 4.9 CB2 (21x) 6.08 JWH-046.svg
JWH-047[1] Naphthoylindole 59 ± 3 3.47 ± 1.80 CB2 (17x) 6.08 JWH-047.png
JWH-048[1] Naphthoylindole 10.7 ± 1.0 0.49 ± 0.13 CB2 (22x) 6.5 JWH-048.png
JWH-049[1] Naphthoylindole 55.1 ± 17.0 32.3 ± 2.4 CB2 (1.7x) 6.92 JWH-049.svg
JWH-050[1] Naphthoylindole 342 ± 6 526 ± 133 CB1 (1.5x) 7.33 JWH-050.svg
JWH-051 Dibenzopyran 1.20 0.03 CB2 (40x) 6.49 JWH-051.svg
JWH-056[2] Dibenzopyran >10000 32 ± 9 CB2 5.92 JWH-056.svg
JWH-057[3] Dibenzopyran 23 ± 7 2.9 ± 1.6 CB2 (8x) 7.55 JWH-057.svg
JWH-065[2] Dibenzopyran 399 ± 76 10 ± 2 CB2 (40x) 6.72 JWH-065.svg
JWH-070[1] Naphthoylindole >10000 >10000 4.02 JWH-070.svg
JWH-071[1] Naphthoylindole 1340 ± 123 2940 ± 852 CB1 (2.2x) 4.36 JWH-071.svg
JWH-072 Naphthoylindole 1050 ± 5.5 170 ± 54 CB2 (6x) 4.84 JWH-072.svg
JWH-073 Naphthoylindole 8.9 ± 1.8 27 ± 12 CB1 (3x) 5.26 JWH 073.svg
JWH-076[4] Naphthoylindole 214 ± 11 106 ± 46 CB2 (2x) 5.33 JWH-076.svg
JWH-077[1] Naphthoylindole >10000 >10000 3.89 JWH-077.svg
JWH-078[1] Naphthoylindole 817 ± 60 633 ± 116 CB2 (1.3x) 4.23 JWH-078.svg
JWH-079[1] Naphthoylindole 63.0 ± 3.0 32.0 ± 6.0 CB2 (2x) 4.72 JWH-079.svg
JWH-080[1] Naphthoylindole 8.9 ± 1.8 2.21 ± 1.30 CB2 (4x) 5.13 JWH-080.svg
JWH-081[1] Naphthoylindole 1.2 ± 0.03 12.4 ± 2.2 CB1 (10x) 5.55 JWH 081.svg
JWH-082[1] Naphthoylindole 5.3 ± 0.8 6.40 ± 0.94 CB1 (1.2x) 5.97 JWH-082.svg
JWH-083[1] Naphthoylindole 106 ± 12 102 ± 50 - 6.38 JWH-083.svg
JWH-093[1] Naphthoylindole 40.7 ± 2.8 59.1 ± 10.5 CB1 (1.45x) 6.37 JWH-093.svg
JWH-094[1] Naphthoylindole 476 ± 67 97.3 ± 2.7 CB2 (4.9x) 5.05 JWH-094.svg
JWH-095[1] Naphthoylindole 140 ± 4.3 312 ± 83 CB1 (2.2x) 7.21 JWH-095.svg
JWH-096[1] Naphthoylindole 33.7 ± 2.9 13.3 ± 5.6 CB2 (2.5x) 5.47 JWH-096.svg
JWH-097[1] Naphthoylindole 455 ± 28 121 ± 15 CB2 (3.8x) 8.04 JWH-097.svg
JWH-098[1] Naphthoylindole 4.5 ± 0.1 1.9 ± 0.3 CB2 (2.4x) 5.89 JWH-098.svg
JWH-099[1] Naphthoylindole 35.3 ± 9.0 17.8 ± 2.9 CB2 (2x) 6.3 JWH-099.svg
JWH-100[1] Naphthoylindole 381 ± 102 155 ± 74 CB2 (2.5x) 6.72 JWH-100.svg
JWH-102[2] Dibenzopyran 7.9 ± 0.9 5.2 ± 2.0 CB2 (1.5x) 6.47 JWH-102.svg
JWH-103[2] Dibenzopyran 28 ± 3 23 ± 7 CB2 (1.2x) 6.47 JWH-103.svg
JWH-116[5] Naphthoylindole 52 ± 5 6.5 JWH-116.svg
JWH-120 Naphthoylindole 6.1 ± 0.7 CB2 (173x) 5.33 JWH-120.png
JWH-122[5] Naphthoylindole 0.69 ± 0.5 1.2 ± 1.2 6.16 JWH-122.svg
JWH-133[2] Dibenzopyran 677 ± 132 3.4 ± 1.0 CB2 (200x) 6.3 JWH-133.png
JWH-139[2] Dibenzopyran 2290 ± 505 14 ± 10 CB2 (164x) 5.88 JWH-139.svg
JWH-142[2] Dibenzopyran 529 ± 49 35 ± 14 CB2 (15x) 7.48 JWH-142.svg
JWH-143[2] Dibenzopyran 924 ± 104 65 ± 8 CB2 (14x) 7.43 JWH-143.svg
JWH-145[6] Naphthoylpyrrole 14 ± 2 6.4 ± 0.4 CB2 (2.2x) 6.35 JWH-145.svg
JWH-146[6] Naphthoylpyrrole 21 ± 2 62 ± 5 CB2 (3.0x) 7.19 JWH-146.svg
JWH-147[6] Naphthoylpyrrole 11 ± 1 7.1 ± 0.2 CB2 (1.5x) 6.72 JWH 147.svg
JWH-148[4] Naphthoylindole 123 ± 8 14.0 ± 1.0 CB2 (8x) 5.67 JWH-148.png
JWH-149[4] Naphthoylindole 5.0 ± 2.1 0.73 ± 0.03 CB2 (6.8x) 6.5 JWH-149.png
JWH-150[6] Naphthoylpyrrole 60 ± 1 15 ± 2 CB2 (4x) 6.27 JWH-150.svg
JWH-151[4] Naphthoylindole >10000 30 ± 1.1 CB2 (>333x) 5.05 JWH-151.svg
JWH-153[4] Naphthoylindole 250 ± 24 11 ± 0.5 CB2 (23x) 5.89 JWH-153.svg
JWH-156[6] Naphthoylpyrrole 404 ± 18 104 ± 18 CB2 (4x) 5.86 JWH-156.svg
JWH-159[4] Naphthoylindole 45 ± 1 10.4 ± 1.4 CB2 (4.3x) 5.89 JWH-159.svg
JWH-160[4] Naphthoylindole 1568 ± 201 441 ± 110 CB2 (3.6x) 5.05 JWH-160.svg
JWH-161 Dibenzopyran hybrid 19.0 5.86 JWH-161.svg
JWH-163[4] Naphthoylindole 2358 ± 215 138 ± 12 CB2 (17x) 4.72 JWH-163.svg
JWH-164[4] Naphthoylindole 6.6 ± 0.7 6.9 ± 0.2 5.55 JWH-164.svg
JWH-165[4] Naphthoylindole 204 ± 26 71 ± 8 CB2 (2.9x) 4.72 JWH-165.svg
JWH-166[4] Naphthoylindole 44 ± 10 1.9 ± 0.08 CB2 (23x) 5.55 JWH-166.svg
JWH-167 Phenylacetylindole 90 ± 17 159 ± 14 CB1 (1.77x) 4.62 JWH-167.svg
JWH-171 Hydrocarbon 51 6.91 JWH-171.svg
JWH-175 Naphthylmethylindole 22 6.56 JWH-175.svg
JWH-176 Hydrocarbon 26 6.91 JWH 176.svg
JWH-180[4] Naphthoylindole 26 ± 2 9.6 ± 2.0 CB2 (2.7x) 6.16 JWH-180.svg
JWH-181[4] Naphthoylindole 1.3 ± 0.1 0.62 ± 0.04 CB2 (2.1x) 7.33 JWH-181.svg
JWH-182[4] Naphthoylindole 0.65 ± 0.03 1.1 ± 0.1 7 JWH-182.svg
JWH-184 Naphthylmethylindole 23 7.05 JWH-184.svg
JWH-185 Naphthylmethylindole 17 6.43 JWH-185.svg
JWH-186[7] Dibenzopyran 187 ± 23 5.6 ± 1.7 CB2 (33x) JWH-186.svg
JWH-187[7] Dibenzopyran 84 ± 16 3.4 ± 0.5 CB2 (25x) JWH-187.svg
JWH-188[7] Dibenzopyran 270 ± 58 18 ± 2 CB2 (15x) JWH-188.svg
JWH-190[7] Dibenzopyran 8.8 ± 1.4 1.6 ± 0.03 CB2 (5.5x) JWH-190.svg
JWH-191[7] Dibenzopyran 1.8 ± 0.3 0.52 ± 0.03 CB2 (3.5x) JWH-191.svg
JWH-192 Naphthylmethylindole 41 4.99 JWH-192.svg
JWH-193 Naphthoylindole 6 4.1 JWH-193.svg
JWH-194 Naphthylmethylindole 127 7.38 JWH-194.svg
JWH-195 Naphthylmethylindole 113 4.5 JWH-195.svg
JWH-196 Naphthylmethylindole 151 ± 18 6.9 JWH-196.svg
JWH-197 Naphthylmethylindole 323 6.77 JWH-197.svg
JWH-198 Naphthoylindole 10 3.49 JWH-198.svg
JWH-199 Naphthylmethylindole 20 4.37 JWH-199.svg
JWH-200 Naphthoylindole 42 3.62 JWH-200.svg
JWH-201[8] Phenylacetylindole 1064 ± 21 444 ± 14 CB2 (2.4x) 4.5 JWH-201.svg
JWH-202[8] Phenylacetylindole 1678 ± 63 645 ± 6 CB2 (2.6x) 4.83 JWH-202.svg
JWH-203[8] Phenylacetylindole 8.0 ± 0.9 7.0 ± 1.3 5.18 JWH-203.svg
JWH-204[8] Phenylacetylindole 13 ± 1 25 ± 1 CB1 (1.9x) 5.52 JWH-204.svg
JWH-205[8] Phenylacetylindole 124 ± 23 180 ± 9 CB1 (1.45x) 4.96 JWH-205.svg
JWH-206[8] Phenylacetylindole 389 ± 25 498 ± 37 CB1 (1.28x) 5.18 JWH-206.svg
JWH-207[8] Phenylacetylindole 1598 ± 134 3723 ± 10 CB1 (2.33x) 5.52 JWH-207.svg
JWH-208[8] Phenylacetylindole 179 ± 7 570 ± 127 CB1 (3.18x) 5.11 JWH-208.svg
JWH-209[8] Phenylacetylindole 746 ± 49 1353 ± 270 CB1 (1.81x) 5.45 JWH-209.svg
JWH-210[4] Naphthoylindole 0.46 ± 0.03 0.69 ± 0.01 CB1 (1.5x) 6.58 JWH-210.svg
JWH-211[4] Naphthoylindole 70 ± 0.8 12 ± 0.8 CB2 (5.8x) 6.08 JWH-211.svg
JWH-212[4] Naphthoylindole 33 ± 0.9 10 ± 1.2 CB2 (3.3x) 5.75 JWH-212.svg
JWH-213[4] Naphthoylindole 1.5 ± 0.2 0.42 ± 0.05 CB2 (3.6x) 6.92 JWH-213.svg
JWH-215[7] Dibenzopyran 1008 ± 117 85 ± 21 CB2 (12x) JWH-215.svg
JWH-216[7] Dibenzopyran 1856 ± 148 333 ± 104 CB2 (5.6x) JWH-216.svg
JWH-217[7] Dibenzopyran >10000 1404 ± 66 CB2 (>7x) JWH-217.svg
JWH-220 Hydrocarbon 19 7.4 JWH-220.svg
JWH-224[7] Dibenzopyran 347 ± 34 28 ± 1 CB2 (12.3x) JWH-224.svg
JWH-225[7] Dibenzopyran >10000 325 ± 70 CB2 (>31x) JWH-225.svg
JWH-226[7] Dibenzopyran 4001 ± 282 43 ± 3 CB2 (93x) JWH-226.svg
JWH-227[7] Dibenzopyran 40 ± 6 4.4 ± 0.3 CB2 (9x) JWH-227.svg
JWH-229[9] Dibenzopyran 3134 ± 110 18 ± 2 CB2 (174x) JWH-229.svg
JWH-230[7] Dibenzopyran 15 ± 3 1.4 ± 0.12 CB2 (10.7x) JWH-230.svg
JWH-233[7] Dibenzopyran 14 ± 3 1.0 ± 0.3 CB2 (14x) JWH-233.svg
JWH-234[4] Naphthoylindole 8.4 ± 1.8 3.8 ± 0.6 CB2 (2.2x) 6.58 JWH-234.svg
JWH-235[4] Naphthoylindole 338 ± 34 123 ± 34 CB2 (2.7x) 5.75 JWH-235.svg
JWH-236[4] Naphthoylindole 1351 ± 204 240 ± 63 CB2 (5.6x) 6.08 JWH-236.svg
JWH-237[8] Phenylacetylindole 38 ± 10 106 ± 2 CB1 (2.8x) 5.18 JWH-237.svg
JWH-239[4] Naphthoylindole 342 ± 20 52 ± 6 CB2 (6.6x) 6.58 JWH-239.svg
JWH-240[4] Naphthoylindole 14 ± 1 7.2 ± 1.3 CB2 (1.9x) 7.42 JWH-240.svg
JWH-241[4] Naphthoylindole 147 ± 20 49 ± 7 CB2 (3.0x) 6.92 JWH-241.svg
JWH-242[4] Naphthoylindole 42 ± 9 6.5 ± 0.3 CB2 (6.5x) 7.75 JWH-242.svg
JWH-243[6] Naphthoylpyrrole 285 ± 40 41 ± 3 CB2 (6.95x) 6.23 JWH-243.svg
JWH-244[6] Naphthoylpyrrole 130 ± 6 18 ± 1 CB2 (7.22x) 6.84 JWH-244.svg
JWH-245[6] Naphthoylpyrrole 276 ± 4 25 ± 2 CB2 (11x) 6.91 JWH-245.svg
JWH-246[6] Naphthoylpyrrole 70 ± 4 16 ± 1 CB2 (4.38x) 6.91 JWH-246.svg
JWH-247[7] 427 ± 31 99 ± 4 CB2 (4.3x) JWH-247.svg
JWH-248[8] Phenylacetylindole 1028 ± 39 657 ± 19 CB2 (1.56x) 5.45 JWH-248.svg
JWH-249[8] Phenylacetylindole 8.4 ± 1.8 20 ± 2 CB1 (2.38x) 5.45 JWH-249.svg
JWH-250[8] Phenylacetylindole 11 ± 2 33 ± 2 CB1 (3x) 4.5 JWH 250.svg
JWH-251[8] Phenylacetylindole 29 ± 3 146 ± 36 CB2 (5x) 5.11 JWH-251.svg
JWH-252[8] Phenylacetylindole 23 ± 3 19 ± 1 CB2 (1.2x) 5.45 JWH-252.svg
JWH-253[8] Phenylacetylindole 62 ± 10 84 ± 12 CB1 (1.35x) 4.83 JWH-253.svg
JWH-254[7] Dibenzopyran 4724 ± 509 319 ± 16 CB2 (14.8x) JWH-254.svg
JWH-256[7] Dibenzopyran 4300 ± 888 97 ± 18 CB2 (44x) JWH-256.svg
JWH-258[4] Naphthoylindole 4.6 ± 0.6 10.5 ± 1.3 CB1 (2.3x) 5.89 JWH-258.svg
JWH-259[4] Naphthoylindole 220 ± 29 74 ± 7 CB2 (3.0x) 5.05 JWH-259.svg
JWH-260[4] Naphthoylindole 29 ± 0.4 25 ± 1.9 CB2 (1.2x) 6.22 JWH-260.svg
JWH-261[4] Naphthoylindole 767 ± 105 221 ± 14 CB2 (3.5x) 5.39 JWH-261.svg
JWH-262[4] Naphthoylindole 28 ± 3 5.6 ± 0.7 CB2 (5.0x) 6.92 JWH-262.svg
JWH-265[4] Naphthoylindole 3788 ± 323 80 ± 13 CB2 (47x) 4.72 JWH-265.svg
JWH-266[4] Naphthoylindole >10000 455 ± 55 CB2 (>22x) 5.05 JWH-266.svg
JWH-267[4] Naphthoylindole 381 ± 16 7.2 ± 0.14 CB2 (53x) 5.55 JWH-267.svg
JWH-268[4] Naphthoylindole 1379 ± 193 40 ± 0.6 CB2 (34x) 5.89 JWH-268.svg
JWH-277[7] Dibenzopyran 3905 ± 91 589 ± 65 CB2 (6.6x) JWH-277.svg
JWH-278[7] Dibenzopyran 906 ± 80 69 ± 6 CB2 (13x) JWH-278.svg
JWH-292[6] Naphthoylpyrrole 29 ± 1 20 ± 1 CB2 (1.45x) 6.23 JWH-292.svg
JWH-293[6] Naphthoylpyrrole 100 ± 5 41 ± 4 CB2 (2.44x) JWH-293.svg
JWH-298[7] Dibenzopyran 812 ± 67 198 ± 23 CB2 (4.1x) JWH-298.svg
JWH-299[7] Dibenzopyran 415 ± 50 30 ± 2 CB2 (13.8x) JWH-299.svg
JWH-300[7] Dibenzopyran 118 ± 16 5.3 ± 0.1 CB2 (22x) JWH-300.svg
JWH-301[7] Dibenzopyran 295 ± 64 48 ± 4 CB2 (6.1x) JWH-301.svg
JWH-302[8] Phenylacetylindole 17 ± 2 89 ± 15 CB1 (5.26x) 4.5 JWH-302.svg
JWH-303[8] Phenylacetylindole 117 ± 10 138 ± 12 CB1 (1.18x) 5.52 JWH-303.svg
JWH-304[8] Phenylacetylindole 3363 ± 332 2679 ± 688 CB2 (1.26x) 5.79 JWH-304.svg
JWH-305[8] Phenylacetylindole 15 ± 1.8 29 ± 5 CB1 (1.93x) 5.79 JWH-305.svg
JWH-306[8] Phenylacetylindole 25 ± 1 82 ± 11 CB1 (3.28x) 4.83 JWH-306.svg
JWH-307[6] Naphthoylpyrrole 7.7 ± 1.8 3.3 ± 0.2 CB2 (2.33x) 6.51 JWH 307.svg
JWH-308[6] Naphthoylpyrrole 41 ± 1 33 ± 2 CB2 (1.24x) 6.51 JWH-308.svg
JWH-309[6] Naphthoylpyrrole 41 ± 3 49 ± 7 CB1 (1.20x) 7.35 JWH-309.svg
JWH-310[7] Dibenzopyran 1059 ± 51 36 ± 3 CB2 (29x) JWH-310.svg
JWH-311[8] Phenylacetylindole 23 ± 2 39 ± 3 CB1 (1.70x) 4.78 JWH-311.svg
JWH-312[8] Phenylacetylindole 72 ± 7 91 ± 20 CB1 (1.26x) 4.78 JWH-312.svg
JWH-313[8] Phenylacetylindole 422 ± 19 365 ± 92 CB2 (1.16x) 4.78 JWH-313.svg
JWH-314[8] Phenylacetylindole 39 ± 2 76 ± 4 CB1 (1.95x) 5.12 JWH-314.svg
JWH-315[8] Phenylacetylindole 430 ± 24 182 ± 23 CB2 (3.36x) 5.12 JWH-315.svg
JWH-316[8] Phenylacetylindole 2862 ± 670 781 ± 105 CB2 (3.66x) 5.12 JWH-316.svg
JWH-336[7] Dibenzopyran 4589 ± 367 153 ± 15 CB2 (30x) JWH-336.svg
JWH-338[7] Dibenzopyran >10000 111 ± 16 CB2 (>90x) JWH-338.svg
JWH-339[7] Dibenzopyran >10000 2317 ± 93 CB2 (>4.3x) JWH-339.svg
JWH-340[7] Dibenzopyran 135 ± 6 30 ± 1 CB2 (4.5x) JWH-340.svg
JWH-341[7] Dibenzopyran 100 ± 8 10 ± 0.1 CB2 (10x) JWH-341.svg
JWH-346[6] Naphthoylpyrrole 67 ± 6 39 ± 2 CB2 (1.72x) 6.84 JWH-346.svg
JWH-347[6] Naphthoylpyrrole 333 ± 17 169 ± 17 CB2 (1.97x) 7.35 JWH-347.svg
JWH-348[6] Naphthoylpyrrole 218 ± 19 53 ± 1 CB2 (4.11x) 7.28 JWH-348.svg
JWH-349[7] Dibenzopyran 376 ± 1 38 ± 4 CB2 (9.9x) JWH-349.svg
JWH-350[7] Dibenzopyran 395 ± 50 12 ± 1 CB2 (33x)
JWH-351[7] Dibenzopyran >10000 295 ± 3 CB2 (>34x) JWH-351.svg
JWH-352[7] Dibenzopyran >10000 47 ± 2 CB2 (>213x) JWH-352.svg
JWH-353[7] Dibenzopyran 1493 ± 10 31 ± 1 CB2 (48x) JWH-353.svg
JWH-354[7] Dibenzopyran 1961 ± 21 241 ± 14 CB2 (8.1x) JWH-354.svg
JWH-355[7] Dibenzopyran 2162 ± 220 108 ± 17 CB2 (20x) JWH-355.svg
JWH-356[7] Dibenzopyran 5837 ± 701 108 ± 17 CB2 (54x) JWH-356.svg
JWH-357[7] Dibenzopyran 647 ± 78 185 ± 4 CB2 (3.5x) JWH-357.svg
JWH-358[7] Dibenzopyran 1243 ± 266 52 ± 3 CB2 (24x) JWH-358.svg
JWH-359 Dibenzopyran 2918 ± 450 13.0 ± 0.2 CB2 (220x) 6.5 JWH-359.svg
JWH-360[7] Dibenzopyran 2449 ± 606 160 ± 8 CB2 (15x) JWH-360.svg
JWH-361[7] Dibenzopyran 63 ± 3 2.7 ± 0.1 CB2 (23x) JWH-361.svg
JWH-362[7] Dibenzopyran 127 ± 8 34 ± 5 CB2 (3.7x) JWH-362.svg
JWH-363[6] Naphthoylpyrrole 245 ± 5 71 ± 1 CB2 (3.45x) 7.28 JWH-363.svg
JWH-364[6] Naphthoylpyrrole 34 ± 3 29 ± 1 CB2 (1.17x) 7.26 JWH-364.svg
JWH-365[6] Naphthoylpyrrole 17 ± 1 3.4 ± 0.2 CB2 (5.0x) 7.26 JWH-365.svg
JWH-366[6] Naphthoylpyrrole 191 ± 12 24 ± 1 CB2 (7.96x) 5.02 JWH-366.svg
JWH-367[6] Naphthoylpyrrole 53 ± 2 23 ± 1 CB2 (2.30x) 6.23 JWH-367.svg
JWH-368[6] Naphthoylpyrrole 16 ± 1 9.1 ± 0.7 CB2 (1.76x) 6.51 JWH-368.svg
JWH-369[6] Naphthoylpyrrole 7.9 ± 0.4 5.2 ± 0.3 CB2 (1.52x) 6.91 JWH-369.svg
JWH-370[6] Naphthoylpyrrole 5.6 ± 0.4 4.0 ± 0.5 CB2 (1.40x) 6.84 JWH-370.svg
JWH-371[6] Naphthoylpyrrole 42 ± 1 64 ± 2 CB1 (1.52x) 8.09 JWH-371.svg
JWH-372[6] Naphthoylpyrrole 77 ± 2 8.2 ± 0.2 CB1 (9.39x) 7.28 JWH-372.svg
JWH-373[6] Naphthoylpyrrole 60 ± 3 69 ± 2 CB1 (1.15x) 8.09 JWH-373.svg
JWH-387 Naphthoylindole 1.2 1.1
JWH-398 Naphthoylindole 2.3 2.8 6.23 JWH-398.svg
JWH-424 Naphthoylindole 20.9 5.44 6.51 JWH-424 structure.png
  • JWH-007 — an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 receptor and CB2 receptors, with some selectivity for CB2 with a Ki of 2.9nM ± 2.6 and 9.5nM ± 4.5 at CB1.[4]
  • JWH-015 — a chemical from the naphthoylindole family, which acts as a subtype-selective cannabinoid agonist. Its affinity for CB2 receptors is 13.8nM, while its affinity for CB1 is 383nM, meaning that it binds almost 28x more strongly to CB2 than CB1.[4]
  • JWH-018 — an analgesic chemical from the naphthoylindole family, which acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2 with a Ki of 2.9nM ± 2.6 and 9nM ± 5 at CB1.[4] It is found in some forms of synthetic cannabis.
  • JWH-019 — an agonist at both CB1 and CB2 receptors, it has 1.77x selectivity for CB2 with a Ki of 5.55nM ± 2 and 9.8nM ± 2 at CB1.
  • JWH-030 — an analgesic chemical from the naphthoylpyrrole family, it is a partial agonist at CB1 receptors, with a Ki of 87nM, making it roughly half the potency of THC.
  • JWH-047 — a potent and selective agonist for the CB2 receptor with a Ki of 0.9 nM, and a Ki of 59 ± 3 nM at CB1, it has a 65x selectivity for CB2.[4]
  • JWH-048 — a potent and selective agonist for the CB2 receptor with a Ki of 0.49 nM ± 0.1, and a Ki of 10.7 nM ± 1.0 at CB1, it has a 22x selectivity for CB2.[4]
  • JWH-051 — an analgesic, it has high affinity for the CB1 receptor, but is a much stronger agonist for CB2, with a Ki value of 0.03nM at CB2 vs 1.20nM at CB1. It was one of the first CB2-selective ligands developed, although its selectivity for CB2 is modest compared to newer compounds such as HU-308.
  • JWH-057 — a 1-deoxy analog of Δ8-THC that has very high affinity for the CB2 receptor, but also has high affinity for the CB1 receptor.[10]
  • JWH-073 — an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is somewhat selective for the CB1 subtype with a Ki of 8.9nM. It is found in some forms of synthetic cannabis.
  • JWH-081 — an analgesic chemical from the naphthoylindole family, which acts as an agonist at both the cannabinoid receptors with a Ki of 1.2nM ± 0.03 at CB1[5] and 12.4nM ± 2.2 at the CB2 receptors. It is fairly selective for the CB1 subtype with approximately 10x the affinity for CB2. It is found in some forms of synthetic cannabis.
  • JWH-098 — a potent and fairly selective CB2 agonist with a Ki of 1.9nM ± 0.3 at CB2 and 4.5nM ± 0.1 at CB1,[5] giving it about 2.4x selectivity for CB2.
  • JWH-116 — a CB1 ligand with a Ki of 52 ± 5 nM[5]
  • JWH-120 — a potent and 173-fold selective CB2 agonist with a Ki of 6.1nM ± 0.7, it is the N-propyl homolog of JWH-122.[10]
  • JWH-122 — a potent and fairly selective CB1 agonist with a Ki of 0.69nM ± 0.05 at CB1[5] and 1.2nM ± 1.2 at CB2. It is found in some forms of synthetic cannabis.
  • JWH-133 — a potent and highly selective CB2 receptor agonist with a Ki of 3.4nM and selectivity of around 200x for CB2 over CB1 receptors.[4]
  • JWH-139 — 3-(1,1-dimethylpropyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromene[11]
  • JWH-147 — an analgesic drug from the naphthoylpyrrole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is somewhat selective for the CB2 subtype, with a Ki of 11.0nM at CB1 vs 7.1nM at CB2.
  • JWH-148 — a moderately selective ligand for the CB2 receptor, with a binding affinity of Ki = 14.0 ± 1.0 nM at this subtype, and more than 8 times selectivity over the CB1 subtype.[4]
  • JWH-149 — a potent and fairly selective CB2 agonist with a Ki of 0.73nM ± 0.03 and 5.0nM ± 2.1 at CB1,[5] giving it about 6.8x selectivity for CB2.
  • JWH-161 — a CB1 ligand with Ki of 19.0nM
  • JWH-164 — a potent cannabinoid agonist with a Ki of 6.6nM ± 0.7 at CB1 and 6.9nM ± 0.2 at CB2.
  • JWH-166 — a potent and highly selective CB2 agonist with a Ki of 1.9nM ± 0.08 at CB2 and 44nM ± 10 at CB1 giving it 23x selectivity for CB2.[4]
  • JWH-167 — a weak cannabinoid agonist from the phenylacetylindole family with 1.77x selectivity for CB1 with a Ki of 90nM ± 17 at CB1 and 159nM ± 14 at CB2.[8]
  • JWH-171 — an analgesic drug which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is only 51nM, making it slightly less potent than THC itself.
  • JWH-175 — (1-pentylindol-3-yl)naphthalen-1-ylmethane, 22nM at CB1[5]
  • JWH-176 — 1-([(1E)-3-pentylinden-1-ylidine]methyl)naphthalene, 26nM at CB1[5]
  • JWH-181 — a potent cannabinoid agonist with 2.1x selectivity for CB2 with a Ki of 0.62nM ± 0.04 and 1.3nM ± 0.1 at CB1.
  • JWH-182 — a potent cannabinoid agonist with some selectivity for CB1 with a Ki of 0.65nM ± 0.03 and 1.1nM ± 0.1 at CB2.
  • JWH-184 — 1-pentyl-1H-indol-3-yl-(4-methyl-1-naphthyl)methane, 23nM at CB1[5]
  • JWH-185 — 1-pentyl-1H-indol-3-yl-(4-methoxy-1-naphthyl)methane, 17nM at CB1[5]
  • JWH-192 — (1-(2-morpholin-4-ylethyl)indol-3-yl)-4-methylnaphthalen-1-ylmethane, 41nM at CB1[5]
  • JWH-193 — (1-(2-morpholin-4-ylethyl)indol-3-yl)-4-methylnaphthalen-1-ylmethanone, 6nM at CB1[5]
  • JWH-194 — 2-methyl-1-pentyl-1H-indol-3-yl-(4-methyl-1-naphthyl)methane, 127nM at CB1[5]
  • JWH-195 — (1-(2-morpholin-4-ylethyl)indol-3-yl)-naphthalen-1-ylmethane, 113nM at CB1[5]
  • JWH-196 — 2-methyl-3-(1-naphthalenylmethyl)-1-pentyl-1H-Indole, 151nM ± 18 at CB1
  • JWH-197 — 2-methyl-1-pentyl-1H-indol-3-yl-(4-methoxy-1-naphthyl)methane, 323nM at CB1[5]
  • JWH-198 — (1-(2-morpholin-4-ylethyl)indol-3-yl)-4-methoxynaphthalen-1-ylmethanone, 10nM at CB1[5]
  • JWH-199 — (1-(2-morpholin-4-ylethyl)indol-3-yl)-4-methoxynaphthalen-1-ylmethane, 20nM at CB1[5]
  • JWH-200 — an analgesic chemical from the aminoalkylindole family, which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is 42nM, around the same as that of THC, but its analgesic potency in vivo was higher than that of other analogues with stronger CB1 binding affinity in vitro, around 3 times that of THC but with less sedative effect, most likely reflecting favorable pharmacokinetic characteristics. It is found in some forms of synthetic cannabis.
  • JWH-203 — an analgesic chemical from the phenylacetylindole family, which acts as a cannabinoid agonist with approximately equal affinity at both the CB1 and CB2 receptors, having a Ki of 8.0nM at CB1 and 7.0nM at CB2. Similar to the related 2'-methoxy compound JWH-250, JWH-203 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds, and is the most potent compound found in the phenylacetyl group.[8] It is found in some forms of synthetic cannabis.
  • JWH-205 — 1-(2-methyl-1-pentylindol-3-yl)-2-phenylethanone, CB1: 124nM ± 23 CB2: 180nM ± 9 CB2 selectivity: 1.45x[8]
  • JWH-210 — an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with Ki values of 0.46nM at CB1 and 0.69nM at CB2. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower Ki) at CB1 than both its 4-methyl and 4-n-propyl homologues (JWH-122 and JWH-182 respectively), and than the 4-methoxy compound JWH-081.[4] It is found in some forms of synthetic cannabis.
  • JWH-213 — a potent and fairly selective CB2 agonist with a Ki of 0.42nM ± 0.05 at CB2 and 1.5nM ± 0.2 at CB1 giving it 3.6x selectivity over CB1.[4]
  • JWH-220 — 19nM at CB1
  • JWH-229 — 1-methoxy-3-(1',1'-dimethylhexyl)-Δ8-THC, a dibenzopyran "classical" cannabinoid drug with a Ki of 18nM ± 2.0, it is a potent CB2 agonist.[9]
  • JWH-234 — a cannabinoid agonist that has 2.2x selectivity for CB2 with a Ki value of 8.4nM ± 1.8 at CB2 and 3.8nM ± 0.6 at CB1.
  • JWH-249 — CB1: 8.4nM ± 1.8 CB2: 20nM ± 2 selectivity for CB1: 2.38x[8]
  • JWH-250 — an analgesic chemical from the phenylacetylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors, with a Ki of 11nM at CB1 and 33nM at CB2.[8] It is found in some forms of synthetic cannabis.
  • JWH-251 — (1-pentyl-3-(2-methylphenylacetyl)indole) CB1: 29nM ± 3 CB2: 146nM ± 36 selectivity for CB1: 5x[8]
  • JWH-253
  • JWH-258 — a potent and mildly selective CB1 agonist with a Ki of 4.6nM ± 0.6 and 10.5nM ± 1.3 at CB2.[4]
  • JWH-300 — CB1: 116nM CB2: 5.3nM[10]
  • JWH-302 — (1-pentyl-3-(3-methoxyphenylacetyl)indole) CB1: 17nM ± 2 CB2: 89nM ± 15 selectivity for CB1: 5.26x[8]
  • JWH-307 — an analgesic drug from the naphthoylpyrrole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is somewhat selective for the CB2 subtype, with a Ki of 7.7nM at CB1 vs 3.3nM at CB2.
  • JWH-336 — CB1: ~1.2nM CB2: 36nM[10]
  • JWH-350 — an 11-nor-1-methoxy-3-(1',1'-dimethylheptyl)-9α-hydroxyhexahydrocannabinol with 33-fold selectivity for the CB2 receptor and high CB2 receptor affinity (Ki=12nM ± 1) has the desirable combination of excellent CB2 affinity combined with little affinity for the CB1 receptor.[10]
  • JWH-359 — a dibenzopyran "classical" cannabinoid drug with a Ki of 13.0nM and selectivity of around 220x for CB2, it is a potent and selective CB2 receptor agonist.
  • JWH-387 — 1-pentyl-3-(4-bromo-1-naphthoyl)indole, an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both receptors with a Ki of 1.2nM at CB1 and 1.1nM at CB2.
  • JWH-398 — an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both receptors with a Ki of 2.3nM at CB1 and 2.8nM at CB2.[12]
  • JWH-424 — a potent and moderately selective CB2 agonist with a Ki of 5.44nM at CB2 and 20.9nM at CB1.

See also[edit]

References[edit]

  1. ^ a b c d e f g h i j k l m n o p q r s t u v w x Aung MM, Griffin G, Huffman JW, Wu M, Keel C, Yang B, Showalter VM, Abood ME, Martin BR (August 2000). "Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB(1) and CB(2) receptor binding". Drug and Alcohol Dependence. 60 (2): 133–40. doi:10.1016/S0376-8716(99)00152-0. PMID 10940540. 
  2. ^ a b c d e f g h Huffman JW, Liddle J, Yu S, Aung MM, Abood ME, Wiley JL, Martin BR (December 1999). "3-(1',1'-Dimethylbutyl)-1-deoxy-delta8-THC and related compounds: synthesis of selective ligands for the CB2 receptor". Bioorganic & Medicinal Chemistry. 7 (12): 2905–14. PMID 10658595. 
  3. ^ Huffman JW, Yu S, Showalter V, Abood ME, Wiley JL, Compton DR, Martin BR, Bramblett RD, Reggio PH (September 1996). "Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor". Journal of Medicinal Chemistry. 39 (20): 3875–7. doi:10.1021/JM960394Y. PMID 8831752. 
  4. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, Thompson AL, Bushell S, Tartal C, Hurst DP, Reggio PH, Selley DE, Cassidy MP, Wiley JL, Martin BR (January 2005). "Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists". Bioorganic & Medicinal Chemistry. 13 (1): 89–112. doi:10.1016/j.bmc.2004.09.050. PMID 15582455. 
  5. ^ a b c d e f g h i j k l m n o p q r Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, Reggio PH, Wiley JL, Martin BR (February 2003). "3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor". Bioorganic & Medicinal Chemistry. 11 (4): 539–49. doi:10.1016/S0968-0896(02)00451-0. PMID 12538019. 
  6. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR (October 2006). "1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors". Bioorganic & Medicinal Chemistry Letters. 16 (20): 5432–5. doi:10.1016/j.bmcl.2006.07.051. PMID 16889960. 
  7. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap Marriott KS, Huffman JW (2008). "Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor". Current Topics in Medicinal Chemistry. 8 (3): 187–204. doi:10.2174/156802608783498014. PMID 18289088. 
  8. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah Huffman JW, Szklennik PV, Almond A, Bushell K, Selley DE, He H, Cassidy MP, Wiley JL, Martin BR (September 2005). "1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles". Bioorganic & Medicinal Chemistry Letters. 15 (18): 4110–3. doi:10.1016/j.bmcl.2005.06.008. PMID 16005223. 
  9. ^ a b Huffman JW, Bushell SM, Miller JR, Wiley JL, Martin BR (December 2002). "1-Methoxy-, 1-deoxy-11-hydroxy- and 11-hydroxy-1-methoxy-Delta(8)-tetrahydrocannabinols: new selective ligands for the CB2 receptor". Bioorganic & Medicinal Chemistry. 10 (12): 4119–29. PMID 12413866. 
  10. ^ a b c d e Poso A, Huffman JW (January 2008). "Targeting the cannabinoid CB2 receptor: modelling and structural determinants of CB2 selective ligands". British Journal of Pharmacology. 153 (2): 335–46. doi:10.1038/sj.bjp.0707567. PMC 2219524Freely accessible. PMID 17982473. 
  11. ^ Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG (June 2002). "International Union of Pharmacology. XXVII. Classification of cannabinoid receptors". Pharmacological Reviews. 54 (2): 161–202. doi:10.1124/pr.54.2.161. PMID 12037135. 
  12. ^ "The Cannabinoid Receptors". 2009. doi:10.1007/978-1-59745-503-9. ISBN 978-1-58829-712-9. Retrieved 28 August 2013.