There are currently 17 U.S. Routes—15 mainline routes and two official special routes—that exist entirely or partially in New York. In New York, U.S. Routes are mostly maintained by the New York State Department of Transportation (NYSDOT), with some exceptions. U.S. Routes in New York are generally directly referenced by NYSDOT with their number; however, the letter "U" is suffixed to the number of the route on reference markers and in internal documents if there is numerical duplication between a U.S. Route and a state route. Two such numerical duplications exist: U.S. Route 2 and New York State Route 2 (US 2 and NY 2; inventoried as "2U" and "2", respectively), and formerly US 15 and NY 15 ("15U" and "15"). A third would exist between US 220 and NY 220; however, the New York portion of US 220 is locally maintained.
The "From" column indicates the southern or western terminus of the route; likewise, the "To" column indicates the northern or eastern terminus of the route. The "mi" and "km" columns give the length of the route in miles and kilometers, respectively. Designations that are shaded in dark gray are numbers not currently assigned to a highway.
US 9E was the designation ultimately assigned to the proposed US 109 from New York City to Waterford. At Waterford, US 9E merged with US 9W to become US 9. Most of US 9E was absorbed by an extended US 9 in 1930.
US 15 followed a generally northerly alignment through southeastern Steuben County from Lawrenceville, Pennsylvania, to Painted Post, where it ended at an interchange with I-86. IT formerly extended north along NY 15 and NY 415 to Rochester, where it ended. It was truncated in 1974 to end at I-86, and it was truncated again in 2014-15 to end at Interstate 99 on the Pennsylvania-New York state line. All of US 15 between I-86 and Pennsylvania became I-99.
US 20 extends across the entire state, from Ripley in the west to New Lebanon in the east. It passes through Buffalo and Albany and serves several smaller cities in the Finger Lakes region, where US 20 has a lengthy overlap with NY 5.
US 62 Business follows Pine Avenue from NY 104 to US 62. The route connects US 62 to the Pine Avenue commercial district and Hyde Park, a large city park northeast of downtown. US 62 Business was formerly NY 62A.
^ abAutomobile Legal Association (ALA) Automobile Green Book, 1930–31 and 1931–32 editions, (Scarborough Motor Guide Co., Boston, 1930 and 1931). The 1930–31 edition shows New York state routes prior to the 1930 renumbering