This is a list of notable alumni of the University of North Alabama or its predecessors such as LaGrange College, Florence Wesleyan University and Florence State University:
- Donald B. Dodd, Emeritus professor of history at Auburn University Montgomery and a noted authority on Southern Unionism in northwest Alabama, particularly the Republic of Winston.
- Lorri Glover, professor of history, Saint Louis University, and author of five books on colonial and post-Revolutionary American history.
- David F. Kern, associate professor and McAdams Frierson Chair of Bank Management at Arkansas State University.
- Thomas L. Maddin (1826-1908), Confederate physician, professor of medicine at the Vanderbilt University School of Medicine
- Danny B. Moore, professor, provost and vice president of Academic Affairs, Chowan University.
- Robert C. Snyder, English professor at Louisiana Tech University, 1947-1989.
- David Weir (academic), professor emeritus at Cooper Union, expert on Decadent Movement in literature and its impact on America.
Arts and entertainment
Country music singer and composer Darryl Worley, who holds a degree in organic chemistry from UNA.
- Walt Aldridge, composer of “There’s No Getting Over Me” and “Holding Her and Loving You”
- Clay Bennett, Pulitzer Prize-winning editorial cartoonist
- David Hood, world-renowned bassist, member of Alabama Music Hall of Fame
- Patterson Hood, composer and front man, Drive-by Truckers
- Priyanka Karki, Nepalese actress, former Miss Teen Nepal, VJ, singer, choreographer, model, and dancer
- George "Goober" Lindsey, actor and narrator, founder of George Lindsey Film Festival
- Pam Long, Miss Alabama 1974, scriptwriter of television's Guiding Light
- Michael 'Nick' Nichols ’78, photographer and Editor-at-large, National Geographic
- Thomas Sigismund Stribling, Pulitzer Prize-winning writer
- Glenn Shadix, actor of stage and screen
- Mark Thompson, radio personality, Mark & Brian Morning Show
- Steve Trash, magician, environmental advocate, children's entertainer
- Danny Vinson, actor, best known for role as David Chamber in episode "Live Bait" of The Walking Dead
- John Paul White, Grammy Award-winning singer-songwriter, The Civil Wars
- Darryl Worley, country music singer-songwriter
- Tom York, host of Tom York Morning Show, Emmy Award winner
- Jim Blasingame, founder of Small Business Network, author, syndicated radio show host
- Wendell Wilkie Gunn, first black student admitted to Florence State Teachers College.
Law, government and politics
Lawrence Sullivan Ross, Confederate States Army general and Texas governor, 1887-91, was a graduate of Florence Wesleyan University, now the University of North Alabama.
- Miles C. Allgood (graduated 1898), United States Representative from Alabama (1923–1935)
- Edward B. Almon, United States Representative from Alabama (1915–1933)
- Billy Joe Camp, Alabama Secretary of State, Public Service Commissioner and Gubernatorial Press Secretary
- Mike Curtis (politician), member, Alabama House of Representatives, representing 2nd District
- Ronnie Flippo, former member of the United States Congress
- Paul Hubbert, executive director, Alabama Education Association; 1990 Democratic gubernatorial nominee
- Tammy Irons, member, Alabama Senate, representing 1st District
- Hiram Raleigh Kennedy, physician and member of the Alabama Senate representing the 1st District
- Edward A. O'Neal, Confederate General and Alabama Governor, 1882 to 1886
- Emmet O'Neal, Alabama Governor, 1911 to 1915
- Lawrence Sullivan Ross, Confederate General, Governor of Texas, president of Texas A&M University
- Annette Taddeo, Democratic Party activist; 2008 Democratic nominee for Florida's 18th Congressional District.
- Chris D. Jackson, Lawrence County, Tennessee county commissioner and civic leader; youngest elected county commissioner in Tennessee history 
- Tyrone Bell, former Green Bay Packers defensive back
- Bobby Collins, former NFL player
- Tony Dorsey, pro basketball player with the Newcastle Eagles
- Will Hall, Former Head Coach University of West Alabama and University of West Georgia, currently Offensive Coordinator at University of Louisiana at Lafayette
- Corey Harris, NFL player
- Harlon Hill, former NFL player, namesake of the NCAA Division II Harlon Hill Trophy
- Janoris Jenkins, cornerback, New York Giants
- Marcus Keyes, football player
- Ronald McKinnon, NFL player, Harlon Hill trophy winner and recent inductee into the College Football Hall of Fame
- Evan Oglesby, cornerback, Dallas Cowboys
- Preston Parker, wide receiver, Tampa Bay Buccaneers
- Israel Raybon, football player
- Wimp Sanderson, former University of Alabama head basketball coach
- Brian Satterfield, former Green Bay Packers running back
- Robert Steele, former NFL wide receiver
- Josh Willingham, former Florida Marlins and Washington Nationals, and Oakland A's outfielder and current Minnesota Twin
- ^ Smith, William E., "Leo's Tale: University of North Alabama Trivia, Florence, AL, Shoals Heritage Publishers, 2000.
- ^ Allison, John (1905). Notable Men of Tennessee: Personal and Genealogical, with portraits. Atlanta, Georgia: Southern historical Association. pp. 104–106. OCLC 2561350 – via Internet Archive.
- ^ Benner, Judith Ann (1983), Sul Ross, Soldier, Statesman, Educator, College Station, Texas: Texas A&M University Press, p. 37
- ^ "County Commissioner Chris Jackson Government Webpage". Lawrence County, TN Government.