"Treehouse of Horror II" - In the 1991 Halloween episode of The Simpsons, one of the stories is about how Homer gets a monkey's paw that grants him four wishes. Each member of the Simpson family (except Marge who actually heeded the warning of the vendor) makes a wish, which have terrible consequences. In a humorous twist, Homer gladly gives the paw to his neighbor Ned Flanders, only for Ned's wishes to (apparently) go off without any of the usual consequences, causing Homer to grumble "I wish I had a monkey paw."
The Cartoon Network show, I Am Weasel featured an episode in its fourth season entitled "The Baboon's Paw" in which Weasel's sidekick, I.R. Baboon, has the power to make his wishes come true through the use of his own paws, having been told they are lucky after attempting to buy a monkey's paw in Chinatown
Bhusan Dahal's 2008 film Kagbeni is based on the story, but with a few changes made to adjust with the locality.
The anime TV series/light novelBakemonogatari story arc, Suruga Monkey, contains an oddity explicitly (albeit incorrectly) believed to be the monkey's paw, with references to its twisted wish-making powers backfiring at the person wishing. However, in contrast to the monkey paw, the wishes are not fulfilled in a way contradicting the intentions of the wish-maker, but actually obeying them.
The 21st episode of the seventh season of The X-Files, Je Souhaite, is a remake of the monkey's paw myth in which Mulder seems to solve the puzzle.
The manga series xxxHolic has a story about a teacher who buys a monkey's paw from Yuko's shop. It was also adapted into the anime series episode "Contract".
The K-Horror movie Wishing Stairs recasts the story with the family replaced by a trio of students at an all-girls school and the monkey paw replaced by the eponymous stairs.
The first episode of the second series of the British comedy The League Of Gentlemen contains a reference to the monkeys paw in the shape of a magical toad which when squeezed will grant the squeezer a wish; it is used by the Dentons to wish for their nephews return and a self lowering lavatory seat.
The cartoon series Adventure Time references the concept directly in the second episode of the fifth season, "Jake the Dog," when heroes Finn and Jake meet a wish-granting being named Prismo. Because he likes Jake, Prismo warns that all his wishes have a catch, "like a monkey's paw thing", and helps guide him into making a wish that will only have negative consequences for the villainous Lich.
A spoof in the cartoon series Rick and Morty, season 1 episode 9, "Something Ricked This Way Comes". The monkeys paw is used to save the life of the devil who lost his will to live after he was outwitted by Rick.