List of adverse effects of risperidone

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List of adverse effects of risperidone:

Sources:[1][2][3]

Note: The percentages provided next to these adverse effects is the incidence of them according to DrugPoint.[1]

Common (≥1%)[edit]

  • Rash (oral, adults, 1% to 4%; pediatrics, up to 11% ; IM, less than 4%)
  • Hyperprolactinaemia (risperidone is probably the most notorious antipsychotic for causing hyperprolactinaemia via its potent blockade of D2 receptors expressed on the lactotrophic cells of the pituitary)[4] (oral, adults, less than 1%; pediatrics, 49% to 87% ; IM, less than 4%)
  • Weight gain (causes less weight gain than clozapine, olanzapine and zotepine, around as much weight gain as quetiapine and more weight gain than amisulpride, aripiprazole, lurasidone, asenapine and ziprasidone)[4] (oral, adult, 8.7% to 20.9%; pediatric, 14% to 32.6% ; IM, adult, 8% to 10%)
  • Seborrhea
  • Constipation (oral, 8% to 21% ; IM, 5% to 7%)
  • Diarrhoea (oral, 1% to 8% ; IM, less than 4%)
  • Excessive Salivation (oral, 1% to 10% ; IM, 1% to 4%)
  • Increased appetite (oral, adult, more than 5%; pediatric, 4% to 47% ; IM, 4%)
  • Indigestion (oral, 2% to 10% ; IM, 6%)
  • Nausea (oral, 4% to 16% ; IM, 3% to 4%)
  • Vomiting (oral, 10% to 25% ; IM, less than 4%)
  • Upper abdominal pain (oral, adult, more than 5%; pediatric, 13% to 16%)
  • Xerostomia (oral, 4% to 15% ; IM, up to 7%)
  • Akathisia (oral, up to 10% ; IM, 4% to 11%)
  • Dizziness (oral, 4% to 16% ; IM, 3% to 11%)
  • Dyspnoea
  • Asthenia
  • Agitation
  • Urinary incontinence
  • Arthralgia
  • Myalgia
  • Epistaxis
  • Somnolence (oral, adult, 3% to 6%; pediatric, 8% to 29% )
  • Sleep disturbances
  • Self harm and suicidal thoughts
  • Dose-dependent extrapyramidal side effects such as dystonia (oral, adult, 3% to 5%; pediatric, 2% to 6% ; IM, adult, less than 4%), tremor (oral, 2% to 12% ; IM, 3% to 24%) and Parkinsonism (oral, 6% to 28% ; IM, 8% to 15%)
  • Blurred vision (oral, 1% to 7% ; IM, 2% to 3%)
  • Anxiety (oral, up to 16% IM, less than 4%)
  • Cough (oral, adults, 2%; pediatrics, 24% ; IM, 2% to 4%)
  • Nasal congestion (oral, adult, 4% to 6%; pediatric, 13%)
  • Nasopharyngitis (oral, adult, 3% to 4%; pediatric, 21%)
  • Pain in the throat (oral, adult, more than 5%; pediatric, 3% to 10%)
  • Upper respiratory tract infection (oral, 2% to 8% ; IM, 2% and 6%)
  • Fatigue (oral, adult, 1% to 3%; pediatric, 18% to 42% ; IM, 3% to 9%)
  • Generalised pains (IM, 1% to 4%)
  • Gynecomastia[5]
  • Galactorrhea[6]
  • Retrograde ejaculation

Rare[edit]

References[edit]

  1. ^ a b Truven Health Analytics, Inc. DrugPoint® System (Internet) [cited 2013 Sep 18]. Greenwood Village, CO: Thomsen Healthcare; 2013.
  2. ^ Joint Formulary Committee. British National Formulary (BNF) 65. Pharmaceutical Pr; 2013.
  3. ^ Australian Medicines Handbook 2013 [Internet]. Australian Medicines Handbook Pty. Limited; 2013. Available from: https://www.amh.net.au/online/auth?timeout&page=index.php
  4. ^ a b Leucht, S; Cipriani, A; Spineli, L; Mavridis, D; Örey, D; Richter, F; et al. (Sep 2013). "Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis". The Lancet. 382 (9896): 951–62. doi:10.1016/S0140-6736(13)60733-3. PMID 23810019. 
  5. ^ http://www.drugdangers.com/risperdal/gynecomastia.htm
  6. ^ "Galactorrhea - side effect of risperidone in combination with depakine chrono in a patient with bipolar disorder". Psychiatr Danub. 22: 125–7. Mar 2010. PMID 20305608.