List of antidepressants

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This is a complete list of clinically-approved prescription antidepressants throughout the world, as well as clinically-approved prescription drugs used to augment antidepressants, by pharmacological and/or structural classification. Chemical/generic names are listed first, with brand names in parentheses. All drugs listed are approved specifically for major depressive disorder unless noted otherwise.

Selective serotonin reuptake inhibitors (SSRIs)[edit]

Zimelidine (Normud, Zelmid) and indalpine (Upstene) were also formerly used as antidepressants, but were withdrawn from the market.

Serotonin-norepinephrine reuptake inhibitors (SNRIs)[edit]

Serotonin modulators and stimulators (SMSs)[edit]

These drugs act as serotonin reuptake inhibitors and agonize/antagonize various serotonin receptors.

Serotonin antagonists and reuptake inhibitors (SARIs)[edit]

These drugs act as antagonists of various serotonin receptors and as weak monoamine reuptake inhibitors.

Norepinephrine reuptake inhibitors (NRIs)[edit]

Atomoxetine (Strattera) is also sometimes used as an antidepressant, but is not specifically approved for this purpose.

Tricyclic antidepressants (TCAs)[edit]

Butriptyline (Evadyne), demexiptiline (Deparon, Tinoran), imipraminoxide (Imiprex, Elepsin), iprindole (Prondol, Galatur, Tetran), metapramine (Timaxel), propizepine (Depressin, Vagran), and quinupramine (Kinupril, Kevopril) were also formerly marketed, but have since been discontinued.

The following are also TCAs, but are atypical pharmacologically:

Amineptine (Survector, Maneon) is another atypical TCA, acting as a norepinephrine-dopamine reuptake inhibitor (NDRI), but was withdrawn from the market.

Tiazesim (Altinil) is technically not a TCA, but it is a heterocyclic antidepressant that is very closely related. Similarly to various TCAs, it is no longer marketed.

Tetracyclic antidepressants (TeCAs)[edit]

Mianserin, mirtazapine, and setiptiline are also sometimes described as noradrenergic and specific serotonergic antidepressants (NaSSAs).

Monoamine oxidase inhibitors (MAOIs)[edit]

Irreversible[edit]

Non-selective[edit]

Many others, including benmoxin (Neuralex), iproclozide (Sursum), iproniazid (Marsilid), mebanazine (Actomol), nialamide (Niamid), octamoxin (Ximaol), pheniprazine (Catron), phenoxypropazine (Drazine), pivhydrazine (Tersavid), and safrazine (Safra) were used as antidepressants in the past, but have since been discontinued.

Selective for MAO-B[edit]

Reversible[edit]

Non-selective[edit]

Caroxazone (Surodil, Timostenil) was formerly used as an antidepressant, but has been discontinued.

Selective for MAO-A[edit]

These drugs are sometimes described as reversible inhibitors of MAO-A (RIMAs).

Eprobemide (Befol) and minaprine (Brantur, Cantor) were also formerly used as antidepressants, but have been discontinued.

Atypical antipsychotics[edit]

  • Amisulpride (Solian) – specifically approved as a monotherapy for dysthymia
  • Lurasidone (Latuda) – specifically approved as a monotherapy for depressive episodes in bipolar disorder
  • Quetiapine (Seroquel) – specifically approved as a monotherapy for depressive episodes in bipolar disorder

Others[edit]

Marketed[edit]

Discontinued/withdrawn from the market[edit]

Over-the-counter[edit]

The following antidepressants are available both with a prescription and over-the-counter:

Adjunctive treatments[edit]

Atypical antipsychotics[edit]

  • Aripiprazole (Abilify) – specifically approved as an adjunct for major depressive disorder
  • Lurasidone (Latuda) – specifically approved as an adjunct for depressive episodes in bipolar disorder
  • Olanzapine (Zyprexa) – specifically approved as an adjunct for major depressive disorder
  • Quetiapine (Seroquel) – approved as an adjunct for both major depressive disorder and depressive episodes in bipolar disorder
  • Ziprasidone (Geodon) - approved by the FDA for the treatment of schizophrenia, and acute mania and mixed states associated with bipolar disorder

Others[edit]

  • Buspirone (BuSpar) – 5-HT1A receptor partial agonist – not specifically approved for depression (used off-label)
  • Lithium (Eskalith, Lithobid) – mood stabilizer (exact mechanism of action unknown) – not specifically approved for depression (used off-label)
  • Thyroxine (T4) – thyroid hormone (THR agonist) – not specifically approved for depression (used off-label)
  • Triiodothyronine (T3) – thyroid hormone (THR agonist) – not specifically approved for depression (used off-label)

Combination products[edit]

Currently in clinical trials (investigational)[edit]

See also[edit]

References[edit]