List of disasters in the United States by death toll

This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources.

This list of United States disasters by death toll includes disasters that occurred either in the United States, at diplomatic missions of the United States, or incidents outside of the United States in which a number of U.S. citizens were killed.

• Domestic deaths due to war in America are included except the American Civil War. For stats on this and U.S. military deaths in foreign locations, see United States military casualties of war.
• Due to inflation, the monetary damage estimates are not comparable. Unless otherwise noted, the year given is the year in which the currency's valuation was calculated.

Over 1,000,000 deaths

Year	Type	Fatalities	Damage (US$)	Article	Location	Comments
2020 – present	Pandemic	1,016,000+	see Economic impact of the COVID-19 pandemic in the United States	COVID-19 pandemic in the United States	Throughout the United States	Fatalities are accurate. Remains the deadliest disaster in United States history.

Over 100,000 deaths

Year	Type	Fatalities	Damage (US$)	Article	Location	Comments
1981 – present	Pandemic	700,000		HIV/AIDS in the United States	Throughout the United States	Fatalities estimated. Remains the second-deadliest disaster in United States history.
1918 – 1920	Pandemic	675,000		1918 influenza pandemic	Throughout the United States	Fatalities estimated. Remains the third-deadliest disaster in United States history.
1957 – 1958	Pandemic	116,000		1957–1958 influenza pandemic	Throughout the United States	Fatalities estimated. Remains the fourth-deadliest disaster in United States history.
1968	Pandemic	100,000		1968 influenza pandemic	Throughout the United States	Fatalities estimated. Remains the fifth-deadliest disaster in United States history.

Epidemics with lower death tolls are not included below. See List of epidemics for global statistics.

Over 400 deaths

Year	Type	Fatalities	Damage (US$)	Article	Location	Comments
1900	Tropical cyclone	6,000–12,000	$34,000,000 (1900)	1900 Galveston hurricane	Texas	Fatalities estimated. Remains the deadliest natural disaster in United States history.
1936	Heat wave	5,000		1936 North American heat wave	United States, Canada
1862	Flood	4,000+	$100,000,000 (1862)	Great Flood of 1862	Western United States
1899	Tropical cyclone	3,389	$20,000,000 (1899)	1899 San Ciriaco hurricane	Puerto Rico, East Coast of the United States
1906	Earthquake and fire (urban conflagration)	3,000+	$235,000,000 (1906)	1906 San Francisco earthquake	San Francisco, California	Conflagration followed quake; fatalities estimated; also major casualties in Santa Rosa and San Jose. Deadliest earthquake in U.S. history.
2001	Terrorism	2,996	$10,000,000,000 (2001)	September 11 attacks	New York City, Arlington County, Virginia, and Stonycreek Township near Shanksville, Pennsylvania	2,977 victims and 19 hijackers. Deadliest in New York City and the Washington, D.C. metropolitan area.
2017	Tropical cyclone	2,982 (estimated)	$94,500,000,000 (2017)	Hurricane Maria	Puerto Rico, United States Virgin Islands, East Coast of the United States	Total includes at least 2,975 deaths based on a study by GWU on the estimated excess mortality. The official death count was previously 64. The storm caused $90 billion (2017 USD) in damage in Puerto Rico, and three deaths in the U.S. Virgin Islands, as well as an additional 75 deaths and $1.6 billion in damage across the rest of the Caribbean.
1928	Tropical cyclone	2,823	$800,000,000 (2005)	1928 Okeechobee hurricane	Florida, Puerto Rico	4,000+ believed dead total. Includes 2,511+ in the contiguous United States, 312 in Puerto Rico.
1941	Military strike – bombing	2,467		Attack on Pearl Harbor	Honolulu, Territory of Hawaii and nearby military installations	2,403 U.S. victims and 64 Japanese attackers. Deadliest attack on U.S. soil by a foreign government to date.
1889	Accident – dam burst	2,209		Johnstown Flood	Pennsylvania	Much rain, deforestation; dam failed
1893	Tropical cyclone	2,000		1893 Cheniere Caminada hurricane	Louisiana	Fatalities estimated
1865	Accident – shipwreck	1,700		Sultana	Marion, Arkansas	Steamboat sank due to boiler explosion; fatalities estimated. Deadliest maritime disaster in U.S. history
1980	Heat wave	1,700	$20,000,000,000 (1980 USD)	1980 United States heat wave	Central and southern states	Official death toll, may have been higher
1871	Wildfire	1,500–2,500		Peshtigo Fire	Peshtigo, Wisconsin, Upper Peninsula of Michigan	Fatalities estimated; most deaths in single fire in U.S. history
1896	Heat wave	1,500		1896 Eastern North America heat wave	Northeastern United States, Midwestern United States	Fatalities estimated
2005	Tropical cyclone	1,245–1,836	$125,000,000,000 (2005)	Hurricane Katrina	Florida, Louisiana, Mississippi, Alabama, Georgia, Kentucky, and Ohio	Tied with Hurricane Harvey as the costliest natural disaster in U.S. history.
1943	Military strike – bombing	1,173		HMT Rohna	Mediterranean Sea	Luftwaffe glide bomb hit troopship causing the largest loss of U.S. soldiers (1,050) at sea due to enemy action in a single incident.
1904	Accident – shipwreck	1,021		PS General Slocum	East River near New York City	Steamship sank due to fire on board. Deadliest maritime disaster in New York City, and deadliest in city's history until 2001.
1893	Tropical cyclone	1,000–2,000		1893 Sea Islands hurricane	Georgia, South Carolina	Fatalities estimated
1918	Wildfire (rural)	1,000	$7,300,000	1918 Cloquet fire	Minnesota
1978	Mass murder	918		Jonestown	Jonestown, Guyana	Jim Jones, cult leader of the Peoples Temple Agricultural Project, convinced most of the group to drink grape Flavor Aid poisoned with cyanide or to inject themselves and their children with cyanide, totaling 909 deaths of U.S. nationals. A family of four other Temple members committed murder/suicide by knife in Georgetown. Five others were shot and killed while trying to escape from Jonestown, including U.S. Congressman Leo Ryan.
1945	Military strike – submarine	879		USS Indianapolis	Philippine Sea	Largest loss of life in the history of the U.S. Navy at sea
1915	Accident – shipwreck	844		SS Eastland	Chicago, Illinois	Passenger ship capsized in Chicago harbor while loading charter for company picnic, causing great loss of life despite shallow water and proximity to land. Deadliest disaster in the history of Great Lakes shipping, and deadliest disaster in Chicago history.
1944	Military strike – submarine	819		SS Léopoldville	English Channel	Approximately 763 United States Army soldiers drowned.
1875	Tropical cyclone	800		1875 Indianola hurricane	Louisiana, Texas	Fatalities estimated
1944	Military strike – E-boats	749		Exercise Tiger	English Channel	USS LST-289, LST-507 and LST-531 sunk during a training exercise.
1925	Tornado outbreak	747	$1,650,000,000 (2005)	Tornado outbreak of March 18, 1925	Missouri, Illinois, Indiana, Kentucky, Tennessee	At least 12 tornadoes, including the following: Tri-State Tornado: 695 deaths (deadliest tornado in U.S. history) Buck Lodge, Tennessee/Beaumont, Kentucky: 41 deaths
1919	Tropical cyclone	745		1919 Florida Keys hurricane	Florida, Texas	Including 488 deaths aboard SS Valbanera
1995	Heat wave	739		Chicago Heat Wave of 1995	Chicago, Illinois
1942	Military strike – submarine	683		USS Juneau	Guadalcanal	Sunk by submarine while retreating with damage from naval battle of Guadalcanal.
1938	Tropical cyclone	682–800		1938 New England hurricane
1943	Military strike – submarine	675		SS Dorchester	Greenland	United States troopship.
1913	Flood	650		Great Flood of 1913	Central United States, Eastern United States	Fatalities estimated
1943	Military strike – submarine	644		USS Liscombe Bay	Gilbert Islands	Submarine torpedo detonated the aircraft carrier's bomb magazine during Operation Galvanic.
1903	Fire (building)	602		Iroquois Theatre fire	Chicago, Illinois	Worst theater fire in American history; worst single-building fire.
1928	Accident – dam failure	600		St. Francis Dam	Santa Clarita, California
1947	Accident – explosion	581		Texas City disaster	Texas City, Texas	Ammonium nitrate on board ship
1896	Tornado outbreak sequence	501+	$2,900,000,000 (1997)	Tornado outbreak sequence of May 1896	Central United States, Southern United States	At least 38 tornadoes, including the following: 1896 St. Louis–East St. Louis tornado: 255–400 deaths Sherman, Texas: 73+ deaths Ortonville–Thomas–Oakwood, Michigan: 47+ deaths Seneca–Oneida, Kansas/Falls City, Nebraska: 25+ deaths Imbs–Germantown, Illinois: 24 deaths
1804	Tropical cyclone	500+		1804 Antigua–Charleston hurricane	Southeastern United States
1865	Accident – fire, shipwreck	500		American steamship General Lyon (1864)	Off Cape Hatteras, North Carolina	Fatalities estimated
1871	Wildfire (rural)	500		Great Michigan Fire	Michigan	Fatalities estimated
1942	Fire (building)	492		Cocoanut Grove fire	Boston, Massachusetts	Deadliest nightclub fire ever, and second-deadliest structure fire in U.S. history; loss of life due to blocked exits; burn victims were among the first treated with penicillin
1927	Exploitation, silicosis	476–1,000+		Hawks Nest Tunnel disaster	Gauley Bridge, West Virginia	178 admitted deaths, 476 with congressional inquiry, 1,000+ by epidemiologists.
1936	Tornado outbreak	454+		1936 Tupelo–Gainesville tornado outbreak	Alabama, Arkansas, Mississippi, Georgia, South Carolina, Tennessee	At least 12 tornadoes, including the following: Tupelo, Mississippi: 216+ deaths Gainesville, Georgia: 203+ deaths
1913	Flood	428		1913 (Ohio) statewide flood	Ohio
1894	Wildfire (rural)	418+		Great Hinckley Fire	Hinckley, Minnesota and vicinity
1957	Tropical cyclone	416	$147,000,000 (1957)	Hurricane Audrey	Louisiana, Texas, Mississippi, Alabama
1935	Tropical cyclone	408		1935 Labor Day hurricane	Florida

201 to 400 deaths

Year	Type	Fatalities	Damage (US$)	Article	Location	Comments
1857	Accident – shipwreck	400		SS Central America	Off the coast of Georgia	Fatalities estimated
1860	Accident – shipwreck	400		PS Lady Elgin	Chicago, Illinois
1888	Blizzard	400		Great Blizzard of 1888	Northeastern United States	Fatalities estimated
1898	Storm	400+		Portland Gale	New England
1937	Flood	385	$5,000,000,000	Ohio River flood of 1937	Ohio, Kentucky, Indiana, Illinois
1917	Tornado outbreak sequence	383+	$6,880,000	May–June 1917 tornado outbreak sequence	Midwestern United States, Southeastern United States	At least 66 tornadoes, including the following: Mattoon–Charleston, Illinois: 101+ deaths Tiptonville, Tennessee/Dublin, Kentucky: 67 deaths Sumiton–Morris, Alabama: 27 deaths Cheney–Florence, Kansas: 23 deaths Blytheville, Arkansas/Como, Tennessee: 18 deaths Ellsinore–Drum, Missouri: 18 deaths
1950	Blizzard	383	$66,700,000 (1950)	Great Appalachian Storm of November 1950	Eastern United States
1911	Heat wave	380+		1911 Eastern North America heat wave	Northeastern United States
1926	Tropical cyclone	372		1926 Miami hurricane	Florida
1944	Accident – explosion	372		USS Mount Hood	New Guinea	Ammunition ship explosion.
1909	Tropical cyclone	371+		1909 Grand Isle hurricane	Gulf Coast of the United States
1907	Accident – coal mine	362		Monongah mining disaster	Monongah, West Virginia
1913	Flood	361		Great Dayton Flood	Dayton, Ohio	Flood was created by a series of three winter storms that hit the region in March, 1913
2011	Tornado outbreak	348	~$11,000,000,000 (2011)	2011 Super Outbreak	Midwestern United States, Southern United States, Eastern United States	Including 24 non-tornadic deaths; 360 tornadoes, including the following: Hackleburg–Phil Campbell, Alabama: 72 deaths Tuscaloosa–Birmingham, Alabama: 64 deaths Fyffe–Rainsville–Sylvania–Ider, Alabama: 25 deaths Smithville, Mississippi: 23 deaths Shoal Creek Valley–Ohatchee–Piedmont, Alabama/Cave Spring, Georgia: 22 deaths Ringgold, Georgia/Southeast Tennessee: 20 deaths
1932	Tornado outbreak	330+	$4,340,000	1932 Deep South tornado outbreak	Southern United States	At least 36 tornadoes, including 10 violent (F4 or F5) storms, resulting in 268 deaths in Alabama alone. Deadliest tornadoes include the following: Cox–Union Grove, Alabama: 49+ deaths Gantts Quarry–Chandler Springs, Alabama: 41 deaths Jackson County, Alabama/Jasper, Tennessee: 38+ deaths Ralph–Northport, Alabama: 37 deaths Plantersville–Sylacauga, Alabama: 31 deaths Cullman–Arab, Alabama: 18 deaths Dalton, Georgia/Conasauga, Tennessee: 15 deaths
1900	Fire (industrial)	326+		1900 Hoboken Docks fire	Hoboken, New Jersey	Including 99 deaths on SS Saale
1908	Tornado outbreak	324+		1908 Dixie tornado outbreak	Great Plains, Midwestern United States, Southern United States	At least 29 tornadoes, including the following: Amite, Louisiana/Purvis, Mississippi: 143 deaths Concordia Parish, Louisiana/near Natchez, Mississippi: 91 deaths Bergens/Albertville, Alabama: 35 deaths
1930	Fire (building)	322		Ohio Penitentiary	Columbus, Ohio
1944	Accident – explosion	320		Port Chicago disaster	Port Chicago, California	World War II ammunition ignited
1840	Tornado	317+	$1,260,000	Great Natchez Tornado	Natchez, Mississippi
1974	Tornado outbreak	310	$3,500,000,000 (2005)	1974 Super Outbreak	Ontario, Illinois, Indiana, Michigan, Ohio, Kentucky, Tennessee, Alabama, Mississippi, Georgia, North Carolina, Virginia, West Virginia and New York	Additional 9 deaths in Ontario; 148 tornadoes, including the following: Xenia, Ohio: 32 deaths Brandenburg, Kentucky: 31 deaths Tanner, Alabama (1st): 28 deaths Guin, Alabama: 28 deaths Monticello, Indiana: 18 deaths Tanner, Alabama (2nd): 16 deaths
1865	Accident – explosion	300		Mobile magazine explosion	Mobile, Alabama	Civil War ammunition; fatalities estimated
1921	Race massacre	300		Tulsa race massacre	Tulsa, Oklahoma	White mob attacks affluent black neighborhood; fatalities estimated
1944	Tropical cyclone	300–400		1944 Great Atlantic hurricane	East Coast of the United States	Fatalities estimated
1937	Accident – explosion	296–319	$13,000,000 (2003)	New London School explosion	New London, Texas	Gas leak
1960	Blizzard	286		December 1960 nor'easter	Northeastern United States
1859	Massacre	283+		Mendocino War	Mendocino County, California
1881	Wildfire (rural)	282	$2,347,000	Thumb Fire	Michigan
1876	Fire (building)	278		Brooklyn Theatre fire	Brooklyn, New York
2021	Blizzard	276–702	$20,400,000,000	February 13–17, 2021 North American winter storm	United States	Additional 14 deaths in Mexico
1915	Tropical cyclone	275		1915 Galveston hurricane	Texas
1915	Tropical cyclone	275		1915 New Orleans hurricane	Louisiana
1898	Explosion	274		USS Maine	Havana, Cuba	A major event that precipitated the Spanish–American War. Exact cause remains unknown.
1875	Accident – shipwreck	273		Pacific (1850)	Off Cape Flattery, Washington	Fatalities estimated
1979	Accident – aircraft	273		American Airlines Flight 191	Chicago, Illinois	Deadliest aircraft accident in U.S. history
1943	Military strike – submarine	272		Henry R. Mallory	North Atlantic	United States troopship.
1965	Tornado outbreak	271		Palm Sunday tornado outbreak	Iowa, Ohio, Michigan, Indiana	78 tornadoes, including the following: Coldwater Lake–Southern Hillsdale–Manitou Beach–Devils Lake–Southern Tecumseh, Michigan: 44 deaths from two tornadoes Southern Elkhart–Dunlap, Indiana: 36 deaths Midway, Indiana: 31 deaths Crawfordsville–Southern Arcadia, Indiana: 28 deaths Toledo, Ohio/Lost Peninsula, Michigan: 18 deaths Pittsfield–Grafton–Strongsville, Ohio: 18 deaths Russiaville–Alto–Southern Kokomo–Greentown, Indiana: 17 deaths
1999	Heat wave	271		1999 heat wave	Midwest and Northeast
1988	Terrorism	270		Pan Am Flight 103	Lockerbie, Scotland	Inflight bombing of a flight from London to New York killed all aboard, including 179 U.S. citizens, and 16 on the ground.
1913	Accident – coal mine	265		Dawson, New Mexico	Dawson, New Mexico	Including 263 miners and two rescuers
2001	Accident – aircraft	265		American Airlines Flight 587	Queens, New York	Second-deadliest U.S. aviation accident, and deadliest in New York City.
1909	Accident – coal mine	259		Cherry Mine disaster	Cherry, Illinois
1932	Tropical cyclone	257		1932 San Ciprián hurricane	Puerto Rico
1937	Accident – coal mine	257			Grundy, Virginia
1969	Tropical cyclone	256		Hurricane Camille	Mississippi, Alabama, and Virginia
1985	Accident – aircraft	256		Arrow Air Flight 1285	Gander, Newfoundland and Labrador, Canada	Most of the passengers were members of the 101st Airborne Division.
1858	Accident – shipwreck	250		Pennsylvania (steamboat)	Mississippi River, near Memphis, Tennessee	Fatalities estimated
1913	Blizzard	250	$5,000,000 (1913)	Great Lakes Storm of 1913	Great Lakes region	Fatalities estimated
1903	Flood	247		Heppner flood of 1903	Heppner, Oregon
1953	Tornado outbreak sequence	247		Flint–Worcester tornado outbreak sequence	Michigan, Ohio, Nebraska and Massachusetts	50 tornadoes, including the following: Northern Flint–Beecher, Michigan: 116 deaths Worcester, Massachusetts: 94 deaths Deshler–Fremont–Fairview Lanes–Northeastern Elyria–Western Cleveland, Ohio: 17 deaths
1927	Flood	246	$400,000,000	Great Mississippi Flood of 1927	Arkansas, Illinois, Kentucky, Louisiana, Mississippi, and Tennessee
1920	Tornado outbreak	243+		April 1920 tornado outbreak	Southern United States	At least 17 tornadoes, including the following Aberdeen, Mississippi/Waco, Alabama: 88 deaths Bay Springs–Russell, Mississippi: 36 deaths Deemer, Mississippi: 27 deaths Lily Flagg–Brownsboro, Alabama: 27 deaths Ingomar–Glen, Mississippi: 24 deaths Carbon Hill–Lacey's Spring, Alabama: 21 deaths
1850	Accident – shipwreck	241–289		SS G. P. Griffith	Lake Erie
1913	Tornado outbreak sequence	241+	$9,680,000	Tornado outbreak sequence of March 1913	Southern United States, Midwestern United States	At least 19 tornadoes, including the following: Omaha, Nebraska: 103 deaths Fulton–Lower Peach Tree, Alabama: 27 deaths Bellevue, Nebraska/Harlan, Iowa: 25 deaths Mead, Nebraska/Logan, Iowa: 22 deaths Prairieton–Terre Haute, Indiana: 21 deaths Douglas, Nebraska/Macedonia, Iowa: 18 deaths
1983	Terrorism	241		1983 Beirut barracks bombings	Beirut, Lebanon	58 French peacekeepers, six civilians and two suicide bombers also died in the attack
1907	Accident – coal mine	239		Darr Mine disaster	Rostraver Township, Westmoreland County, Pennsylvania
1912	Accident – shipwreck	238		RMS Titanic	north Atlantic Ocean, south of Newfoundland	Only includes U.S. victims
1972	Flood	238	$160,000,000 (1972) $664,000,000 (2002)	1972 Black Hills flood	Rapid City, South Dakota	Average rainfall over area of 60 mi2 measured at 10-15 inches (380 mm), over 6 hours in middle of night June 9–10, 1972.
1888	Winter storm	235		Schoolhouse Blizzard	Midwestern United States
1996	Accident – aircraft	230		TWA Flight 800	Long Island, New York
2021	Heat wave	229–600		2021 Western North America heat wave	Pacific Northwest	At least 116 deaths in Oregon, at least 112 in Washington, and one in Idaho
1997	Accident – aircraft	228		Korean Air Flight 801	Asan-Maina, Guam
1865	Accident – shipwreck	225		Brother Jonathan (steamer)	Off Crescent City, California	Fatalities estimated
2006	Heat wave	225		2006 North American heat wave	Contiguous United States
1998	Terrorism	223		1998 United States embassy bombings	Tanzania, Kenya	4,000+ injured
1927	Tornado outbreak	217+		Tornado outbreak of May 1927	Midwestern United States, Southern United States	At least 34 tornadoes, including the following: Imboden, Arkansas/Poplar Bluff, Missouri: 98 deaths Strong, Arkansas: 24 deaths Nevada, Texas: 19 deaths Garland, Texas: 15 deaths
1999	Accident – aircraft	217		EgyptAir Flight 990	Atlantic Ocean near Nantucket, Massachusetts
1902	Accident – coal mine	216		Fraterville Mine disaster	Fraterville, Tennessee
1906	Tropical cyclone	211		1906 Florida Keys hurricane	Florida
1940	Fire (building)	209		Rhythm Club fire	Natchez, Mississippi
1952	Tornado outbreak	209	$285,300,000 (2019)	Tornado outbreak of March 21–22, 1952	Southern United States	31 tornadoes, including the following: Kensett–Judsonia–Russell, Arkansas: 50 deaths Bolivar–Henderson–Chesterfield, Tennessee: 38 deaths Cotton Plant–Hunter, Arkansas: 29 deaths Cooter–Cottonwood Point, Missouri: 17 deaths Byhalia–Cayce, Mississippi/Williston, Tennessee: 16 deaths
1993	Cyclonic blizzard	208	$6,650,000,000 (2008)	1993 Storm of the Century	Eastern United States	Additional 110 deaths in other countries
1896	Tropical cyclone	202	$9,600,000 in 1896 ($289,000,000 in 2018)	1896 Cedar Keys hurricane	Landfall at Cedar Key, Florida;	Heavy damage along much of Eastern Seaboard of U.S.
1966	Blizzard	201		North American blizzard of 1966	Eastern United States

81 to 200 deaths

Year	Type	Fatalities	Damage (US$)	Article	Location	Comments
1854	Accident – shipwreck	200–365		Powhattan (1837)	Harvey Cedars, New Jersey
1856	Tropical cyclone	200+		1856 Last Island hurricane	Louisiana, Mississippi
1871	Fire (urban conflagration)	200–300		Great Chicago Fire	Chicago, Illinois	Fatalities estimated; 125 bodies recovered
1900	Accident – coal mine	200		Scofield Mine disaster	Scofield, Utah	Fatalities estimated
1928	Accident – coal mine	195		Mather Mine disaster	Mather, Pennsylvania
1898	Accident – shipwreck	192		The Portland	Gloucester, Massachusetts
1847	Accident – shipwreck	190–250		SS Phoenix (1845)	Lake Michigan
1996	Winter storm, flood	187		North American blizzard of 1996	Eastern United States	Including 33 deaths due to flooding
1863	Mass murder, military operation	185–200		Lawrence Massacre	Lawrence, Kansas
1955	Tropical cyclone	184+		Hurricane Diane	East Coast of the United States
2011	Tornado outbreak sequence	184	$7,000,000,000 (2011)	Tornado outbreak sequence of May 21–26, 2011	Midwestern United States, Southern United States	Including the Joplin, Missouri tornado, which caused 158 direct and 3 indirect deaths, the latter of which are included here.
1785	Accident – shipwreck	181		Faithful Steward (ship)	Off Cape Henlopen, Delaware Bay
1904	Accident – coal mine	181		Harwick Mine disaster	Cheswick, Pennsylvania	Fatalities estimated
1947	Tornado outbreak	181		1947 Glazier–Higgins–Woodward tornadoes	Oklahoma (especially Woodward), Texas (including Glazier and Higgins), Kansas
1914	Accident – coal mine	180+		Eccles mine disaster	Eccles, West Virginia
1985	Flood	180		1985 Puerto Rico floods	Puerto Rico
1898	Tropical cyclone	179+		1898 Georgia hurricane	Florida, Georgia
1884	Tornado outbreak	178+		Tornado outbreak of February 19–20, 1884	Southeastern United States	At least 37 tornadoes, including the following: Jacksonville, Alabama/Cave Spring, Georgia: 30 deaths Pee Dee–Rockingham–Philadelphia–Manly, North Carolina: 23 deaths Cartersville–Mount Oglethorpe, Georgia: 22 deaths
1908	Fire (building)	175		Collinwood school fire	Cleveland, Ohio	Deadliest school fire in U.S. history; led to many changes in how schools were built.
1924	Accident – coal mine	172		Castle Gate Mine disaster	Castle Gate, Utah	171 miners and one rescue worker
1908	Fire (building)	171		Rhoads Opera House fire	Boyertown, Pennsylvania	Sources conflict on number of fatalities: 170 or 171.
1903	Accident – coal mine	169		Hanna Mine disasters	Carbon County, Wyoming
1880	Tornado outbreak	168+		Tornado outbreak of April 1880	Midwestern United States	At least 20 tornadoes, including the following: Boaz–Evergreen, Missouri: 99 deaths Rocky Comfort–Grovespring: 31 deaths
1917	Fire (mine)	168		Speculator Mine disaster	Butte, Montana
1944	Fire (building)	168		Hartford circus fire	Hartford, Connecticut
1966	Smog incident	168		1966 New York City smog	New York City and New York metropolitan area, including parts of New Jersey and Connecticut	Fatalities estimated
1995	Terrorism	168		Oklahoma City bombing	Oklahoma City, Oklahoma	Deadliest act of domestic terrorism, and deadliest domestic bombing, in U.S. history
1946	Tsunami and Earthquake	165–173		1946 Aleutian Islands earthquake	Alaska, Hawaii
1977	Fire (building)	165		Beverly Hills Supper Club fire	Southgate, Kentucky
1909	Tornado outbreak	164+		Tornado outbreak of late-April 1909	Midwestern United States, Southern United States	At least 35 tornadoes, including the following: Horn Lake, Mississippi/Parsons, Tennessee: 29 deaths Elkmont, Alabama/Fayetteville, Tennessee: 29 deaths
1944	Maritime Accident	163		West Loch disaster	Pearl Harbor, Hawaii	Classified as top secret until 1960.
1956	Blizzard	162		March 18–20, 1956 nor'easter	Northeastern United States
1838	Accident – shipwreck	160		Moselle (riverboat)	Ohio River, near Cincinnati
2012	Tropical cyclone	158	$71,400,000,000	Hurricane Sandy	Most of the United States East Coast	86 indirect fatalities occurred in the United States. 76 additional fatalities occurred in the Caribbean and the Bahamas; 21 people are still missing in Haiti.
1960	Tropical cyclone	157	$491,100,000	Hurricane Donna	The Caribbean, United States East Coast	Includes 107 deaths in Puerto Rico.
1987	Accident – aircraft	156		Northwest Airlines Flight 255	Detroit, Michigan
1940	Winter storm, shipwrecks	154		1940 Armistice Day Blizzard	Midwestern United States	Including 66 deaths in a series of shipwrecks in Lake Michigan, including the SS Anna C. Minch, the SS Novadoc, the SS William B. Davock, and others
1920	Tornado outbreak	153+		1920 Palm Sunday tornado outbreak	Midwestern United States, Southern United States	At least 37 tornadoes, including the following: LaGrange, Georgia: 27 deaths Red Hill–Susanna–Red Ridge–Agricola, Alabama/West Point, Georgia: 26 deaths Ossian–Townley, Indiana/Brunersburg–Raab Corners, Ohio: 23 deaths Channahon–Troy Township–Lockport–Bellwood–Maywood–Melrose Park–Dunning, Illinois: 20 deaths West Liberty–Geneva–Ceylon, Indiana/Van Wert, Ohio: 17 deaths
1982	Accident – aircraft	153		Pan Am Flight 759	New Orleans, Louisiana
1854	Accident – shipwreck	150		New Era (1854 ship)	Off Asbury Park, New Jersey	Fatalities estimated
1890	Mass murder, Mass shooting	150–300		Wounded Knee Massacre	Wounded Knee Creek, South Dakota	White U.S. Cavalry troops went to a Native American reserve and shot and killed between 150 and 300 Native Americans.
1936	Flood	150–200		1936 Northeast Flood	Northeastern United States	Fatalities estimated
1942	Tornado outbreak	149	$5,250,000	Tornado outbreak of March 16–17, 1942	Central United States, Southern United States	At least 28 tornadoes, including the following: Berclair–New Harmony, Mississippi: 63 deaths Bethel Springs–Beacon, Tennessee: 15 deaths
1890	Tornado outbreak	146+		March 1890 middle Mississippi Valley tornado outbreak	Middle Mississippi Valley	At least 24 tornadoes, including the following: Shively, Kentucky/Jeffersonville, Indiana: 76+ deaths Kevil–West Louisville, Kentucky: 21+ deaths
1911	Fire (building)	146		Triangle Shirtwaist Factory fire	New York City, New York	Led to improved occupational safety standards as well as mandatory comprehensive fire safety standards
1976	Flood	145		Big Thompson River	Colorado
1953	Tornado outbreak	144		1953 Waco tornado outbreak	Great Plains, Midwestern United States	Including 114 deaths from an F5 tornado in Waco, Texas
1978	Accident – aircraft	144		PSA Flight 182	San Diego, California
2000	Heat wave	140		2000 Southern United States heat wave	Southern United States
1840	Accident – shipwreck	139		Lexington	Long Island Sound	Steamship sank due to fire on board
1874	Accident – dam failure	139		Mill River (Northampton, Massachusetts)	Hampshire County, Massachusetts
1917	Explosion	139		Eddystone explosion	Eddystone, Pennsylvania
1944	Accident – shipwreck	138		USS Turner (DD-648)	Lower New York Bay
1934	Accident – shipwreck	137		SS Morro Castle (1930)	Off Long Beach Island, New Jersey
1985	Accident – aircraft	137		Delta Air Lines Flight 191	Dallas, Texas
1906	Tropical cyclone	134		1906 Mississippi hurricane	Southeastern United States
1944	Tornado outbreak	134–137		1944 Appalachians tornado outbreak	Midwestern United States, Mid-Atlantic States	At least seven tornadoes, including the following: Wyatt–Shinston–Cheat Mountain, West Virginia: 100–103 deaths Wellsburg, West Virginia/Oakland, Maryland: 30 deaths Pittsburgh–Somerset, Pennsylvania: 17 deaths
1960	Accident – aircraft	134		1960 New York mid-air collision	New York City, New York
1967	Fire (ship)	134	>$72,000,000	1967 USS Forrestal fire	Gulf of Tonkin, Vietnam
1994	Accident – aircraft	132		USAir Flight 427	Pittsburgh, Pennsylvania
1852	Accident – shipwreck	130–300		Atlantic (1848)	Lake Erie
1944	Accident – explosion	130	$7,000,000- $15,000,000	Cleveland East Ohio Gas explosion	Cleveland, Ohio
1963	Accident – Submarine	129		USS Thresher (SSN-593)	Atlantic Ocean, off the coast of Massachusetts	Deadliest submarine disaster in U.S. history.
1838	Accident – shipwreck	128		Steamship Pulaski disaster	Off North Carolina
1901	Accident – shipwreck	128–135		SS City of Rio de Janeiro	San Francisco Bay, California
1911	Accident – coal mine	128		Banner Mine disaster	Alabama
1915	Incident – Maritime	128		Sinking of the RMS Lusitania	Atlantic Ocean near Kinsale, Ireland	Ship torpedoed by a German U-boat. 1,198 fatalities resulted overall; 128 of them were Americans.
1933	Tornado outbreak	128		Early-May 1933 tornado outbreak sequence	Midwestern United States, Southeastern United States	At least 27 tornadoes, including the following: Tompkinsville–Russell Springs, Kentucky: 36 deaths Livingston–Byrdstown, Tennessee: 35 deaths Brent–Pelham, Alabama: 21 deaths Anderson–Fountain Inn, South Carolina: 19 deaths
1945	Tornado outbreak	128		Tornado outbreak of April 1945	Midwestern United States	Including 69 deaths from a tornado in Pushmataha County, Oklahoma
1956	Accident – aircraft	128		1956 Grand Canyon mid-air collision	Grand Canyon, Arizona	Parts of wreckage still visible. Deadliest air disaster in U.S. at that time; led to creation of Federal Aviation Administration two years later.
1972	Accident – dam failure	125		Buffalo Creek flood	Logan County, West Virginia
1923	Accident – coal mine	123		Dawson, New Mexico	Dawson, New Mexico
1929	Fire (building)	123		Cleveland Clinic fire of 1929	Cleveland, Ohio
1971	Tornado outbreak	123	$45,900,000 (1971)	February 1971 Mississippi Delta tornado outbreak	Southern United States, Ohio River Valley	19 tornadoes, including the following: Fitler–Cary–Swiftown–Morgan City–Quito–Oxberry–Oxford, Mississippi/Middleton, Tennessee: 58 deaths Waverly, Louisiana/Mayersville–Delta City–Inverness–Moorehead, Mississippi: 47 deaths
1917	Accident – coal mine	121		Hastings mine explosion	Las Animas County, Colorado
1857	Mass murder	120		Mountain Meadows Massacre	Utah Territory	Mormon settlers executed between 120 and 140 men, women, and children from the Baker-Fancher party wagon train after accepting their surrender from a five-day siege and offering them safe passage through Utah Territory.
1933	Earthquake	120	$50,000,000 (1933)	Long Beach earthquake	Long Beach, California
2005	Tropical cyclone	120	$18,500,000,000 (2005)	Hurricane Rita	Louisiana	Including 23 deaths from a bus fire during evacuations in Wilmer, Texas
1924	Accident – coal mine	119		Benwood mine disaster	Benwood, West Virginia
1946	Fire (building)	119		Winecoff Hotel fire	Atlanta, Georgia
1951	Accident – coal mine	119		West Frankfort, Illinois	West Frankfort, Illinois
1972	Tropical cyclone	119	$2,100,000,000	Hurricane Agnes	Eastern United States
1899	Tornado	117	>$300,000 ($8,381,000 in today's dollars).	New Richmond tornado	New Richmond, Wisconsin	Tornado hit the same time the circus was in town.
1918	Earthquake	116		1918 San Fermín earthquake	Puerto Rico
1837	Accident – shipwreck	115		Wreck of the Mexico	Long Beach, New York	Eight people rescued from shore. One hundred fifteen crew and passengers (mostly Irish immigrants, and many of them women and children) froze to death on the deck of the ship just 200 yards from shore. The wreck of the Mexico is the subject of Walt Whitman's poem, "Sleepers" in Leaves of Grass.
1902	Stampede	115		Shiloh Baptist Church stampede	Birmingham, Alabama
1938	Flood	115	$78 million (1938)	Los Angeles flood of 1938	Los Angeles, California	Deadliest disaster in Los Angeles history
1944	Accident – shipwreck	115		USS St. Augustine (PG-54)	Off Cape May, New Jersey
1964	Tsunami and Earthquake	115	$1,800,000,000 (2006)	Good Friday earthquake	Alaska, Hawaii, Oregon, California
1902	Tornado	114		1902 Goliad, Texas tornado	Goliad, Texas
1924	Tornado outbreak	114		April 1924 tornado outbreak	Southern United States	Including 53 deaths from a single tornado in South Carolina
1981	Accident – collapse	114		Hyatt Regency walkway collapse	Kansas City, Missouri
1975	Accident – aircraft	113		Eastern Air Lines Flight 66	New York City, New York
1863	Riot	112	$1–5 million (1863)	New York City draft riots	New York City, New York	Worst civil unrest in U.S. history required diverting Union Army troops from the front to put down
1902	Accident – coal mine	112		Rolling Mill Mine	Johnstown, Pennsylvania
1905	Tornado	112+		1905 Snyder tornado	Snyder, Oklahoma
1915	Accident – coal mine	112		Layland, West Virginia#Mine disaster	Layland, West Virginia
1916	Tornado outbreak	112+		June 1916 tornado outbreak	Southern United States	Including 25 deaths from a single tornado family in Arkansas
1989	Accident – aircraft	112		United Airlines Flight 232	Sioux City, Iowa
2008	Tropical cyclone	112	$30,000,000,000 (2008)	Hurricane Ike	Texas; Louisiana	34 people still missing as of 2013
1928	Accident – shipwreck	111		SS Vestris	Off Hampton Roads, Virginia
1947	Accident – coal mine	111		Centralia mine disaster	Centralia, Illinois
1971	Accident – aircraft	111		Alaska Airlines Flight 1866	Juneau, Alaska
1869	Accident – coal mine	110		Avondale Mine disaster	Plymouth, Pennsylvania
1996	Accident – aircraft	110		ValuJet Flight 592	Florida Everglades
1891	Accident – coal mine	109		Mammoth Mine disaster	Westmoreland County, Pennsylvania
2017	Tropical cyclone	106	$125,000,000,000 (2017)	Hurricane Harvey	Texas, Louisiana	Tied with Hurricane Katrina as the costliest natural disaster in United States history. One additional death occurred in Guyana.
1837	Tropical cyclone, shipwreck	103		Racer's hurricane	Mexico, Texas, Gulf Coast	Fatalities estimated; including 90 deaths from the wreck of SS Home off Cape Hatteras; additional two deaths occurred in the Republic of Texas
1884	Accident – shipwreck	103		SS City of Columbus	Off Aquinnah, Massachusetts
1955	Tornado outbreak	102		1955 Great Plains tornado outbreak	Central United States	46 tornadoes, including the following: Udall, Kansas: 80 deaths Blackwell, Oklahoma: 20 deaths
1918	Accident – railroad	101		Great Train Wreck of 1918	Nashville, Tennessee	Deadliest rail accident in U.S. history
1963	Accident – aircraft	101		Northwest Airlines Flight 293	Near Annette Island, Alaska
1972	Accident – aircraft	101		Eastern Air Lines Flight 401	Miami, Florida
1812	Tropical cyclone	100		1812 Louisiana hurricane	Louisiana	Fatalities estimated
1852	Accident – shipwreck	100+		Saluda (steamship)	Lexington, Missouri
1865	Accident – shipwreck	100–125		SS Pewabic	Lake Huron
1892	Accident – Coal mine	100		Krebs, Oklahoma	Krebs, Oklahoma (then Choctaw nation, Indian Territory)	Natural gas explosion
1899	Winter storm, cold wave	100+		Great Blizzard of 1899	Contiguous United States
1900	Tropical cyclone	100		1900 Guam typhoon	Guam
1918	Accident – explosion	100		T. A. Gillespie Company Shell Loading Plant explosion	Sayreville, New Jersey	Fatalities estimated
1937	Mass poisoning	100+		Elixir sulfanilamide	United States
1978	Blizzard	100	$1,075,000,000 (2010)	Northeastern United States blizzard of 1978	Northeastern United States	Fatalities estimated
2003	Fire (building)	100		The Station nightclub fire	West Warwick, Rhode Island	4th-deadliest nightclub fire in U.S. history, killing 100 people and injuring more than 200.
1968	Accident – shipwreck	99		USS Scorpion (SSN-589)	North Atlantic Ocean off New London, Connecticut	U.S. Navy investigation of cause was inconclusive, although suggested an internal hydrogen explosion may have been followed by collapse of hull, followed by immediately sinking to ocean floor, killing all hands.
2017	Tropical cyclone	99	$53,400,000,000 (2017)	Hurricane Irma	Puerto Rico, United States Virgin Islands, Eastern United States (particularly Florida)	Includes three deaths and $1 billion (2017 USD) in damage in Puerto Rico, and four deaths and $2.4 billion in damage in the U.S. Virgin Islands. Storm caused an additional 35 deaths and approximately US$11.4 billion in damage across the rest of the Caribbean.
1877	Accident – shipwreck	98		USS Huron (1875)	Off Nags Head, North Carolina
1890	Accident – shipwreck	98		Sea Wing disaster	Lake Pepin near Lake City, Minnesota	Strong winds toppled the excursion vessel.
1922	Roof collapse	98		Knickerbocker Theatre	Washington, District of Columbia	Roof collapsed due to the eponymous Knickerbocker storm
2021	Structural collapse	98		Surfside condominium collapse	Surfside, Florida
1904	Accident – railroad	97		Eden train wreck	Pueblo, Colorado
1974	Accident – aircraft	97		Pan Am Flight 806	Pago Pago, American Samoa
1875	Tornado outbreak	96+		March 1875 Southeast tornado outbreak	Southeastern United States	Including at least 28 deaths from a single tornado between Georgia and South Carolina
1910	Avalanche	96		Wellington avalanche	Wellington, Washington	Avalanche hit 2 trains in Tye Canyon
1977	Accident – aircraft; tornado outbreak	96		Southern Airways Flight 242; Tornado outbreak of April 1977	New Hope, Paulding County, Georgia; tornadoes affected Southeastern United States	Storm system caused the crash of Flight 242, killing 72 people; and spawned an outbreak of 21 tornadoes, killing 24 people, including an F5 which killed 22 people near Birmingham, Alabama
1986	Arson	96–98		Dupont Plaza Hotel arson	San Juan, Puerto Rico
1954	Tropical cyclone	95		Hurricane Hazel	North Carolina; South Carolina	U.S. victims only
1958	Fire (building)	95		Our Lady of the Angels School fire	Chicago, Illinois
1962	Accident – aircraft	95		American Airlines Flight 1	New York City, New York
2021	Tornado outbreak	95		Tornado outbreak of December 10–11, 2021	Southern United States, Midwestern United States	Including 6 non-tornadic and indirect deaths; 71 tornadoes, including the following: Western Kentucky: 58 deaths (including one indirect) Bowling Green, Kentucky: 17 deaths (including one indirect)
1969	Winter storm	94		February 1969 nor'easter	Northeastern United States
1918	Accident – railroad	93		Malbone Street Wreck	Brooklyn, New York	Some accounts give death toll as 101. Deadliest accident on New York City subway, deadliest rail disaster in city's history and deadliest mass-transit accident in U.S. history.
1939	Tropical cyclone	93		1939 California tropical storm	Southern California	Including 48 offshore deaths
1876	Accident – railroad	92		Ashtabula River railroad disaster	Ashtabula, Ohio	Fatalities approximated
1919	Tornado outbreak	92		Tornado outbreak of April 1919	Great Plains	At least 12 tornadoes, including the following: Mineola–Mount Pleasant, Texas: 24 deaths Blue Ridge–Ravenna, Texas: 18 deaths Eustace–Grand Saline, Texas: 17 deaths
1919	Accident – coal mine	92		Baltimore Mine Tunnel disaster	Wilkes-Barre, Pennsylvania
1974	Accident – aircraft	92		TWA Flight 514	Berryville, Virginia
1972	Accident – silver mine	91		Sunshine Mine	Big Creek, Idaho	Mass carbon monoxide poisoning
1899	Fire (building)	90		Windsor Hotel (Manhattan)	Manhattan, New York	Fatalities estimated
1973	Accident – aircraft	89		Delta Air Lines Flight 723	Boston, Massachusetts
1860	Structural collapse	88–145		Pemberton Mill	Lawrence, Massachusetts
1907	Accident – shipwreck	88		SS Columbia (1880)	Off Shelter Cove, California
2000	Accident – aircraft	88		Alaska Airlines Flight 261	Pacific Ocean near Anacapa Island, California
1918	Accident – shipwreck	87		Columbia (collapsed paddle steamer)	Creve Coeur, Illinois
1952	Accident – aircraft	87		1952 Moses Lake C-124 crash	Near Moses Lake, Washington
1990	Fire (building)	87		Happy Land fire	New York City, New York	Arson by disgruntled patron. Deadliest mass murder by a single person in U.S. history.
2021	Tropical cyclone	87		Hurricane Ida	Gulf Coast of the United States, Eastern United States
1910	Wildfire	86		Great Fire of 1910	Washington, Idaho, Montana
1918	Accident – railroad	86		Hammond Circus Train Wreck	Hammond, Indiana
1993	Police raid – Fire	86		Waco siege	Branch Davidian Complex, Waco, Texas	6 Davidians and 4 police killed in initial raid. Weeks later during final FBI assault, 76 Davidians died in a fire of disputed origin.
1878	Accident – shipwreck	85		USS Stars and Stripes (1861)	Currituck, North Carolina
1924	Tornado	85–90	$12,500,000	1924 Lorain–Sandusky tornado	Lorain and Sandusky, Ohio
1951	Accident – railroad	85		Woodbridge train wreck	Woodbridge, New Jersey
1964	Accident – aircraft	85		Paradise Airlines Flight 901A	Near Lake Tahoe, Nevada
1968	Accident – aircraft	85		Braniff Flight 352	Dawson, Texas
1980	Fire (building)	85		MGM Grand fire	Las Vegas, Nevada
2018	Forest fire	85		Camp Fire	Paradise, California	Deadliest fire in California history.
1911	Accident – coal mine	84		Cross Mountain Mine disaster	Briceville, Tennessee
1916	Tropical cyclone, flood	84+		1916 Charleston hurricane	South Carolina, North Carolina, Tennessee, Georgia, Virginia	Most deaths were due to a flood event
1927	Flood	84+		Great Vermont Flood of 1927	Vermont
1965	Accident – aircraft	84		Eastern Air Lines Flight 663	New York City, New York
1977	Flash Flood	84	$300,000,000	Johnstown flood of 1977	Johnstown, Pennsylvania	The flood occurred when an extraordinary amount of rain came down in the Conemaugh Valley in a short period of time. Nearly 12 inches were measured in 10 hours. The National Weather Service later estimated that this amount of rain in that location should happen less than once every 1,000 years.
1999	Tropical cyclone	84		Hurricane Floyd	East Coast of the United States
2007	Winter storm	84		January 2007 North American ice storm	Central United States, Eastern United States	Additional three deaths in Canada
1966	Accident – aircraft	83		American Flyers Flight 280	Near Ardmore, Oklahoma
1969	Accident – aircraft	83		Allegheny Airlines Flight 853	Shelby County, Indiana	A Piper Cherokee 140, piloted by a student who was a week away from getting his private pilot's license, collided with an Allegheny Airlines DC-9. The flight originated in Boston and had stopped in Baltimore and Cincinnati.
1930	Accident – coal mine	82		Millfield Mine disaster	Dover Township, Athens County, Ohio
1967	Accident – aircraft	82		Piedmont Airlines Flight 22	Hendersonville, North Carolina
1986	Accident – aircraft	82		1986 Cerritos mid-air collision	Cerritos, California
1887	Accident – railroad	81–85		Great Chatsworth train wreck	Chatsworth, Illinois
1963	Accident – aircraft	81		Pan Am Flight 214	Elkton, Maryland	Lightning strike
1963	Accident – explosion	81		1963 Indiana State Fairgrounds Coliseum gas explosion	Indianapolis, Indiana

41 to 80 deaths

Year	Type	Fatalities	Damage (US$)	Article	Location	Comments
1813	Accident – shipwreck	80+		USS Hamilton (1809) and USS Scourge	Lake Ontario	Two ships sank during a squall
1880	Accident – shipwreck	80+		PS Alpena	Lake Michigan
1960	Winter storm	80+		March 1960 nor'easter	Northeastern United States
1960	Accident – aircraft	80		World Airways Flight 830	Barrigada, Guam
1943	Accident – railroad	79		Frankford Junction train wreck	Philadelphia, Pennsylvania
1862	Accident – explosion	78		Allegheny Arsenal	Pittsburgh, Pennsylvania	Largest civilian death toll during American Civil War
1875	Fire (building)	78		Precious Blood Church fire	Holyoke, Massachusetts
1911	Dam failure	78		Austin Dam failure (Pennsylvania)	Keating Township, Potter County, Pennsylvania
1950	Accident – railroad	78		Kew Gardens train crash	Kew Gardens, New York	Deadliest surface rail accident in New York City
1961	Accident – aircraft	78		TWA Flight 529	Hinsdale, Illinois
1968	Accident – coal mine	78		Farmington Mine disaster	Farmington, West Virginia
1976	Accident – shipwreck	78		MV George Prince ferry disaster	Mississippi River, Louisiana	Deadliest ferry disaster in U.S. history
1982	Accident – aircraft	78		Air Florida Flight 90	District of Columbia
1923	Fire (building)	77		Cleveland School fire	Camden, South Carolina
1947	Winter storm	77		North American blizzard of 1947	Mid-Atlantic
1929	Accident – shipwreck	77		SS San Juan	Off California	Collided with S.C.T. Dodd
1961	Accident – aircraft	77		Imperial Airlines Flight 201/8	Richmond, Virginia
1985	Tornado outbreak	76	$1,270,000,000 (2019)	1985 United States–Canada tornado outbreak	New York, Ohio, Pennsylvania, Ontario	Including two tornadoes which crossed the Ohio–Pennsylvania border and killed 16 and 18 people respectively; additional 14 deaths in Ontario
1863	Accident – railroad	75		Chunky Creek train wreck	Newton County, Mississippi	Fatalities estimated
1943	Accident – coal mine	75		Smith Mine disaster	Between Bearcreek and Washoe, Montana	74 miners and one rescue worker
1965	Tropical cyclone	75		Hurricane Betsy	Florida, Louisiana
1970	Accident – aircraft	75		Southern Airways Flight 932	Ceredo, West Virginia	Deadliest sports tragedy in U.S. history
1949	Fire (building)	74		St. Anthony's Hospital fire	Effingham, Illinois
1955	Tropical cyclone	74		Hurricane Connie	East Coast of the United States, Puerto Rico	27 deaths in North Carolina, 14 in the Chesapeake Bay, 14 in New York, six in Pennsylvania, six in New Jersey, four in Washington, D.C., and three in Puerto Rico
1956	Accident – aircraft	74		Linea Aeropostal Venezolana Flight 253 (June 1956)	Atlantic Ocean, off New Jersey
1913	Stampede	73		Italian Hall disaster	Calumet, Michigan	Second-largest loss of life within the state of Michigan.
1925	Tropical cyclone	73		1925 Florida tropical storm	East Coast of the United States
1933	Accident – Airship	73		USS Akron	Atlantic Ocean, off the coast of New Jersey	Deadliest airship disaster in history.
1990	Accident – aircraft	73		Avianca Flight 52	Cove Neck, New York
1811	Fire (building)	72		Richmond Theatre fire	Richmond, Virginia
1886	Tornado	72	$400,000	1886 Sauk Rapids tornado	Central Minnesota
1927	Tornado	72–79+	$22,000,000	1927 St. Louis–East St. Louis tornado	St. Louis, Missouri
1932	Accident – explosion	72		Observation (steamboat)	East River, New York City
1943	Accident – railroad	72		Rennert railroad accident	Rennert, North Carolina
1957	Fire (building)	72		Warrenton Nursing Home fire	Warrenton, Missouri
1968	Tornado outbreak	72	$52,500,000	Tornado outbreak of May 1968	Central United States, Southern United States	Including a tornado which struck Jonesboro, Arkansas and killed 35 people in total
1974	Accident – aircraft	72		Eastern Air Lines Flight 212	Charlotte, North Carolina
1878	Tropical cyclone	71		Gale of 1878	East Coast of the United States
1978	Winter storm	71		Great Blizzard of 1978	Great Lakes region
1883	Fire (building)	70+		Newhall House Hotel Fire	Milwaukee, Wisconsin
1967	Accident – aircraft	70		TWA Flight 128	Constance, Kentucky
1954	Tropical cyclone	70		Hurricane Carol	Mid-Atlantic United States, New England
1975	Blizzard, tornado outbreak	70		Great Storm of 1975	Midwestern United States, Southeastern United States	58 deaths from blizzard, 12 from tornadoes
1985	Accident – aircraft	70		Galaxy Airlines Flight 203	Reno, Nevada
1936	Flood	69	$3,000,000,000 (2006)	Pittsburgh Flood of 1936	Pittsburgh, Pennsylvania area
1989	Earthquake	69	$6,000,000,000 (1989)	Loma Prieta earthquake	San Francisco Bay Area, California	Including 42 deaths due to the collapse of the Cypress Street Viaduct
1994	Accident – aircraft	68		American Eagle Flight 4184	Roselawn, Indiana
1888	Accident – railroad	66		Mud Run disaster	Eastern Pennsylvania
1955	Accident – aircraft	66		1955 Hawaii R6D-1 crash	Waianae Range, Hawaii Territory
1955	Accident – aircraft	66		United Airlines Flight 409	Medicine Bow Peak, Wyoming
1902	Wildfires	65+		Yacolt Burn	Washington, Oregon
1959	Accident – aircraft	65		American Airlines Flight 320	New York City, New York
1971	Earthquake	65	$500,000,000	Sylmar earthquake	Greater Los Angeles Area, California
2009	Winter storm	65		January 2009 North American ice storm	Central United States
1903	Accident – railroad	64		Connellsville train wreck	Connellsville, Pennsylvania
1983	Terrorism	64		1983 United States embassy bombing	Beirut, Lebanon
1940	Accident – coal mine	63		Sonman Mine explosion	Portage Township, Cambria County, Pennsylvania
1960	Accident – aircraft	63		Northwest Orient Airlines Flight 710	Tell City, Indiana	Wing failure resulting from freak vibrations in clear weather turbulence was the probable cause.
1963	Fire (building)	63		Golden Age Nursing Home fire	Fitchville, Ohio
1992	Riot	63	~$1,000,000,000	1992 Los Angeles riots	Los Angeles County, California
1960	Accident – aircraft	62		Eastern Air Lines Flight 375	Boston, Massachusetts
1985	Flood	62		1985 Election Day floods	Virginia, West Virginia
1944	Military aircraft, Accident	61		Freckleton air disaster	Freckleton, England	An American United States Army Air Forces Consolidated B-24 Liberator heavy bomber crashed into the center of the village of Freckleton. It crashed into a school, 3 houses, and a cafe. Sixty-one individuals, including 38 children and two teenagers, were killed. Ten American servicemen were among the fatalities.
1946	Fire (building)	61		La Salle Hotel	Chicago, Illinois
1960	Tsunami	61	$500,000 (2005)	Great Chilean earthquake	Hawaii, Alaska	2,290 to 6,600 killed and $3,500,000,000 (2005) in damage worldwide. 61 killed in Hilo, Hawaii. $500,000 in U.S. property damage
1992	Tropical cyclone	61	$27,250,000,000 (1992)	Hurricane Andrew	Florida, Louisiana
2017	Mass shooting	61		2017 Las Vegas shooting	Paradise, Nevada	60 victims and 1 perpetrator, with the perpetrator committing suicide. The deadliest mass shooting by an individual in U.S. history.
1856	Accident – shipwreck	60+		PS Niagara	Off Belgium, Wisconsin
1864	Accident – railroad	60–72		Shohola train wreck	Shohola, Pennsylvania	Train collision along upper Delaware River. Official death toll is 65.
1886	Earthquake	60	$5,000,000–6,000,000	1886 Charleston earthquake	South Carolina, North Carolina, Virginia, East coast of the United States	Massive earthquake starting in South Carolina, spreading across the East Coast of the US.
1966	Tropical cyclone	60		Hurricane Inez	Florida Keys, Gulf Coast of the United States	Including 45 deaths from the capsizing of a boat in the Straits of Florida and 11 deaths from a helicopter crash in the Gulf of Mexico
1967	Winter storm	60		1967 Chicago blizzard	Midwestern United States	26 deaths in Chicago
1856	Accident – railroad	59–67		Great Train Wreck of 1856	Fort Washington, Pennsylvania
1908	Accident – coal mine	59		Hanna Mine disasters	Carbon County, Wyoming
1957	Tornado outbreak sequence	59		May 1957 Central Plains tornado outbreak sequence	Great Plains, Midwestern United States	Including 44 deaths from the Ruskin Heights tornado
2018	Tropical cyclone	59	$25,000,000,000	Hurricane Michael	Florida, Georgia, North Carolina, South Carolina, Virginia	Category 5 hurricane that caused 16 direct and 43 indirect deaths in the US, as well as 15 in Central America
1896	Accident – coal mine	58		Twin Shaft disaster	Pittston, Pennsylvania
1905	Accident – explosion	58		Grover Shoe Factory disaster	Brockton, Massachusetts
1950	Accident – aircraft	58		Northwest Orient Airlines Flight 2501	Lake Michigan	Airplane wreckage never found
1951	Accident – aircraft	58		1951 Miami Airlines C-46 crash	Elizabeth, New Jersey	First of three plane crashes in Elizabeth over three months
1964	Accident – aircraft	58		Eastern Air Lines Flight 304	Lake Pontchartrain, Louisiana
1965	Accident – aircraft	58		American Airlines Flight 383	Cincinnati, Ohio
1966	Tornado	58	$75,500,000	Tornado outbreak of March 3–4, 1966	Southeastern United States	All 58 deaths due to the Candlestick Park tornado
1967	Tornado outbreak	58		1967 Oak Lawn tornado outbreak	Upper Midwest	45 tornadoes, including the following: Oak Lawn–Evergreen Park–Chicago South Side, Illinois: 33 deaths Belvidere, Illinois: 24 deaths
1979	Tornado outbreak	58		1979 Red River Valley tornado outbreak	Midwestern United States, Southern United States	Including the Wichita Falls, Texas tornado which killed 42 people
1903	Tropical cyclone	57		1903 New Jersey hurricane	Mid-Atlantic
1919	Tornado	57	$4,000,000	1919 Fergus Falls tornado	Fergus Falls, Minnesota
1980	Volcano	57	$1,100,000,000	1980 eruption of Mount St. Helens	Washington
1984	Tornado outbreak	57		1984 Carolinas tornado outbreak	Georgia, North Carolina, South Carolina
1994	Earthquake	57	$23,000,000,000	Northridge earthquake	Greater Los Angeles area, California
1999	Tornado outbreak	57	$1,500,000,000 (2005)	1999 Oklahoma tornado outbreak	Oklahoma, Kansas, Texas, Tennessee	66 tornadoes, including the 1999 Bridge Creek–Moore tornado, which killed 36 people; also including seven non-tornadic deaths
2007	Winter storm	57		Mid-December 2007 North American winter storms	Central United States, Eastern United States	Two winter storms in quick succession, the latter of which caused an additional six deaths in Canada
2008	Tornado outbreak	57	$1,200,000,000	2008 Super Tuesday tornado outbreak	Tennessee, Arkansas, Kentucky, Alabama, and Illinois	Including the Castalian Springs–Lafayette, Tennessee/Tompkinsville, Kentucky tornado which killed 22 people
1844	Accident – explosion, shipwreck	56		Lucy Walker steamboat disaster	Ohio River, near New Albany, Indiana	Exact number of fatalities unknown
1875	Accident – shipwreck	56		City of Waco	Off Galveston, Texas
1904	Accident – railroad	56		New Market train wreck	New Market, Tennessee
1912	Tornado outbreak	56		Tornado outbreak of April 20–22, 1912	High Plains, Upper Midwest, Southern United States
1880	Accident – shipwreck, fire	55		SS Narragansett	Long Island Sound	Fatalities estimated
1898	Tornado	55		1898 Fort Smith, Arkansas, tornado	Fort Smith, Arkansas
1905	Winter storm, shipwrecks	55+		Mataafa Storm	Great Lakes region	Approximately 29 vessels destroyed or damaged, including SS Mataafa and SS Ira H. Owen
1943	Fire (building)	55		Gulf Hotel fire	Houston, Texas
1949	Accident – aircraft	55		Eastern Air Lines Flight 537	Alexandria, Virginia
1975	Tropical cyclone	55		Hurricane Eloise	Puerto Rico, Eastern United States
2016	Blizzard	55	$500,000,000, to $3,000,000,000 (2016)	January 2016 United States blizzard	Eastern United States
1932	Accident – coal mine	54		1932 Moweaqua Coal Mine disaster	Moweaqua, Illinois
2004	Tropical cyclone	54	$13,000,000,000 (2004)	Hurricane Ivan	Texas, Florida	Damage and death figures are for the U.S. only. Storm caused an additional 67 deaths and ~US$7 billion in damage across the Caribbean.
2018	Tropical cyclone	54	$24,230,000,000	Hurricane Florence	Virginia, North Carolina, South Carolina	Category 4 hurricane that caused major damage and 54 recorded fatalities in the US; 24 direct and 30 indirect.
1906	Accident – railroad	53		1906 Atlantic City train wreck	Atlantic City, New Jersey
1906	Accident – railroad	53		1906 Washington, D.C., train wreck	Washington, D.C.
1925	Accident – coal mine	53		Coal Glen mine disaster	Farmville, Chatham County, North Carolina
1942	Military strike – bombing	53		Battle of Dutch Harbor	Unalaska, Alaska	43 American and 10 Japanese fatalities. Deadliest attack on continental U.S. by a foreign power since the Mexican–American War.
1947	Accident – aircraft	53		Eastern Air Lines Flight 605	Near Port Deposit, Maryland
1949	Accident – aircraft	53		1949 Strato-Freight Curtiss C-46A crash	West of San Juan-Isla Grande Airport, Puerto Rico
2008	Tropical cyclone	53		Hurricane Gustav	Louisiana, Mississippi, Alabama, Florida
2022	Suspected migrant smuggling operation	53		2022 San Antonio trailer deaths	San Antonio, Texas	Twelve others hospitalized.
1910	Accident – railroad	52		Green Mountain train wreck	Green Mountain, Iowa
1929	Accident – shipwreck	52		SS Milwaukee (1902)	Lake Michigan
1940	Accident – explosion	52		Hercules Powder plant disaster	Roxbury, New Jersey	Fatalities estimated
1940	Tropical cyclone	52		1940 South Carolina hurricane	Georgia, South Carolina, North Carolina, Tennessee, Virginia
1947	Accident – aircraft	52		United Airlines Flight 608	Bryce Canyon, Utah
1952	Accident – aircraft	52		Pan Am Flight 526A	Off San Juan, Puerto Rico
1952	Accident – aircraft	52		1952 Mount Gannett C-124 crash	Mount Gannett, Alaska Territory
2015	Tornado outbreak, winter storm, flood	52	$1,200,000,000 (2015)	December 2015 North American storm complex	Southwestern, Central, and New England	Excluding seven more deaths outside the US
1947	Tropical cyclone	51		1947 Fort Lauderdale hurricane	Florida, Louisiana, Mississippi
1956	Accident – shipwreck	51		SS Andrea Doria, MV Astoria	Off the coast of Nantucket, Massachusetts
1978	Accident – Construction	51		Willow Island disaster	Willow Island, West Virginia	Scaffolding fell 166 feet (51 m) with insufficiently cured concrete
2003	Tropical cyclone, Flooding	51	5,500,000,000 (2003)	Hurricane Isabel	Virginia, Florida, North Carolina, West Virginia, Washington, D.C., Maryland, Delaware, Pennsylvania, New Jersey, New York, Rhode Island, Ontario	Worst hurricane to hit Virginia
1852	Accident – shipwreck	50		Henry Clay (steamboat)	Riverdale, Bronx, New York	Fatalities estimated
1871	Wildfire	50+		Port Huron Fire of 1871	Port Huron, Michigan
1896	Accident – railroad	50		1896 Atlantic City rail crash	Atlantic City, New Jersey
1918	Accident – explosion	50–52		Split Rock, New York	Split Rock, New York
1925	Accident – railroad	50		Rockport train wreck	Hackettstown, New Jersey
1947	Accident – aircraft	50		Pennsylvania Central Airlines Flight 410	Near Charles Town, West Virginia
1951	Accident – aircraft	50		United Airlines Flight 610	West of Fort Collins, Colorado
1951	Accident – aircraft	50		United Airlines Flight 615	Near Decoto, California
1960	Accident – aircraft	50		Capital Airlines Flight 20	Holdcroft, Virginia
1971	Accident – aircraft	50		Hughes Airwest Flight 706	San Gabriel Mountains, Los Angeles County, California
1993	Flood	50	$15,000,000,000	Great Flood of 1993	Midwest
2003	Tornado outbreak sequence	50	$4,100,000,000	Tornado outbreak sequence of May 2003	Great Plains, Eastern United States	Including nine non-tornadic deaths
2009	Accident – aircraft	50		Colgan Air Flight 3407	Clarence Center, New York
2016	Terrorism	50		Orlando nightclub shooting	Orlando, Florida	49 victims and 1 perpetrator, who was shot and killed by police. The second-deadliest mass shooting in U.S. history, after the 2017 Las Vegas shooting.
1867	Accident – railroad	49		Angola Horror	Angola, New York
1892	Accident – explosions	49		Giant Powder Company	Albany, California	Explosion in explosives manufacturing plant destroyed facility, caused extensive damage in nearby Berkeley. Official death toll was 49, though estimates of unrecovered bodies ran higher.
1917	Accident – railroad	49		Shepherdsville train wreck	Shepherdsville, Kentucky
1936	Tornado outbreak	49		1936 Cordele–Greensboro tornado outbreak	Southeastern United States	Including 23 deaths from a tornado near Cordele, Georgia
1953	Tornado outbreak sequence	49	$45,709,000	Tornado outbreak sequence of Early-December 1953	Southeastern United States	Including 38 deaths from the Vicksburg, Mississippi tornado
1958	Accident – aircraft	49		United Airlines Flight 736	Enterprise, Nevada
1989	Tropical cyclone	49	$7,000,000,000 (1989)	Hurricane Hugo	East Coast of the United States.	Damage figure for U.S. only. At least 111 total deaths, with 37 in the continental U.S., as far north as Michigan, and 12 in the U.S. possession of Puerto Rico.
2004	Tropical cyclone	49	$9,000,000,000	Hurricane Frances	Florida
2006	Accident – aircraft	49		Comair Flight 5191	Lexington, Kentucky
2011	Tropical cyclone	49	$15,800,000,000 (2011)	Hurricane Irene	Puerto Rico, East Coast of the United States	49 fatalities in U.S., including 1 in Puerto Rico, with 10 additional fatalities elsewhere.
1853	Accident – railroad	48		Norwalk rail accident	Norwalk, Connecticut
1942	Accident – explosion	48		Joliet Army Ammunition Plant	Will County, Illinois
1944	Accident – railroad	48		Bagley train wreck	West of Ogden, Utah
1958	Accident – railroad	48		Newark Bay rail accident	Newark Bay, New Jersey
1912	Cold wave	47		1912 United States cold wave	Midwestern United States
1917	Tornado outbreak	47+		March 1917 tornado outbreak	Ohio Valley	Including 46 deaths from a single tornado in Indiana and Kentucky
1922	Accident – gold mine	47		Argonaut Mine	Jackson, California
1933	Tropical cyclone	47		1933 Chesapeake–Potomac hurricane	East Coast of the United States
1938	Accident – railroad	47		Custer Creek train wreck	Saugus, Montana
1944	Accident – railroad	47		Stockton train wreck	Stockton, Georgia
1958	Accident – aircraft	47		Capital Airlines Flight 67	Saginaw Bay, near Freeland, Michigan
1989	Accident – explosion	47		USS Iowa turret explosion	Caribbean Sea, off Puerto Rico
1993	Accident – railroad	47		Big Bayou Canot train disaster	Mobile, Alabama	Deadliest train crash in Amtrak history.
2016	Tropical cyclone	47	$10,000,000,000 (2016)	Hurricane Matthew	Florida, Georgia, The Carolinas	Damage and death figures are for the U.S. only. Storm caused an additional 551 deaths and US$5.08 billion in damage across the Caribbean.
1873	Accident – bridge collapse	46		Dixon Bridge Disaster	Dixon, Illinois
1886	Tropical cyclone	46		1886 Indianola hurricane	Indianola, Texas
1900	Accident – coal mine	46		Red Ash Mine disasters	Fire Creek, West Virginia
1916	Accident – railroad	46		Summer Street Bridge disaster	Boston, Massachusetts
1942	Accident – shipwreck	46		USS S-26 (SS-131)	Gulf of Panama
1953	Accident – aircraft	46		National Airlines Flight 470	Gulf of Mexico, off Fort Morgan, Alabama
1961	Tropical cyclone	46	$325.74 million (U.S. only)	Hurricane Carla	Texas, Louisiana	Landed Port O'Connor, Texas on September 11 as Category 4, continued northeast across U.S., dissipated in eastern Canada on September 14.
1967	Accident – Bridge collapse	46		Silver Bridge – over the Ohio River	Point Pleasant, West Virginia Gallipolis, Ohio
1976	Accident – aircraft	46		Air Manila Flight 702	Naval Air Station Agana, Guam
1871	Accident – explosion	45–91		Staten Island Ferry	New York City, New York	Boiler of Westfield II exploded at South Ferry in Manhattan
1912	Tornado outbreak	45+		Tornado outbreak of April 27–29, 1912	Oklahoma, Texas, Louisiana
1927	Mass murder	45		Bath School disaster	Bath Township, Michigan	Deadliest act of school violence in U.S. history
1946	Accident – railroad	45		Naperville train disaster	Naperville, Illinois
1950	Tornado outbreak	45		February 1950 tornado outbreak	Red River of the South, Lower Mississippi Valley	Including 18 deaths from a tornado in northwestern Louisiana
1951	Accident – shipwreck	45		FV Pelican	Off Montauk, New York
1962	Terrorism	45		Continental Airlines Flight 11	Unionville, Missouri
1972	Accident – railroad	45		1972 Chicago commuter rail crash	Chicago, Illinois
1972	Accident – aircraft	45		United Airlines Flight 553	Chicago, Illinois
1925	Structural collapse	44		Pickwick Club collapse	Boston
1933	Tornado outbreak	44		March 1933 Nashville tornado outbreak	Arkansas, Tennessee	At least 5 tornadoes, including the following: Sneedville–Kingsport, Tennessee: 16 deaths Nashville–Lebanon, Tennessee: 15 deaths
1955	Accident – aircraft	44		United Airlines Flight 629	Longmont, Colorado
1957	Accident – aircraft	44		Pan Am Flight 7	Pacific Ocean
1964	Accident – aircraft	44		Pacific Air Lines Flight 773	Near Danville, California
2015	Tornado outbreak, flood	44		2015 Texas–Oklahoma flood and tornado outbreak	Great Plains, Southern United States	Additional 14 deaths occurred in Mexico
2017	Wildfire	44	>$3,000,000,000	October 2017 Northern California wildfires	California	The fires killed 44, injured at least 185 people, and destroyed 5,700 homes
1900	Accident – railroad	43		Tacoma Streetcar Disaster	Tacoma, Washington
1915	Accident – railroad	43	$1,250,000	1915 Ardmore Gas Explosion	Ardmore, Oklahoma	Overpressured tank car filled with casing head gas exploded, causing major damage and death in the town.
1940	Accident – railroad	43		Doodlebug disaster	Cuyahoga Falls, Ohio
1947	Accident – aircraft	43		United Airlines Flight 521	LaGuardia Airport, New York
1948	Accident – aircraft	43		United Airlines Flight 624	Near Aristes, Pennsylvania
1951	Accident – aircraft	43		Cubana de Aviación Flight 493	Key West, Florida
1953	Accident – aircraft	43		USMC R4Q NROTC crash	Milton, Florida
1963	Accident – aircraft	43		Northwest Orient Airlines Flight 705	Everglades, Florida
1965	Accident – aircraft	43		United Airlines Flight 227	Salt Lake City, Utah
1971	Prison riot	43		Attica Prison riot	Attica, New York	State troopers opened non-stop fire on prisoners and hostages after a four-day prison uprising, killing 29 of the former and 10 of the latter; one prison guard had also died at the beginning of the riot. It is considered the deadliest one-day encounter between Americans since the Civil War.
1987	Aircraft hijacking	43		PSA Flight 1771	Near Cayucos, California
2011	Tornado outbreak	43	$2,100,000,000 (2011)	Tornado outbreak of April 14–16, 2011	Oklahoma, Texas, Kansas, Arkansas, Mississippi, Alabama, Missouri, Louisiana, Illinois, Kentucky, Georgia, North Carolina, South Carolina, Virginia, Maryland and Pennsylvania	162 tornadoes
2012	Tornado outbreak	43	$3,500,000,000 (2019)	Tornado outbreak of March 2–3, 2012	Southern United States, Ohio Valley	70 tornadoes, with one of the deadliest in Henryville, Indiana. 41 tornadic deaths, with another 2 from related weather.
2014	Mudflow	43		2014 Oso mudslide	Oso, Washington
1846	Tropical cyclone	42		1846 Havana hurricane	Florida	40 in Key West, Florida, one in Savannah, Georgia, and one in South Carolina
1929	Tornado outbreak	42	Unknown damage	1929 Rye Cove tornado outbreak	Virginia, Central and Eastern United States	Including the thirteenth deadliest tornado strike at a school
1943	Accident – shipwreck	42		USS R-12 (SS-89)	Off Florida
1952	Winter storm	42		February 1952 nor'easter	New England	Fatalities estimated
1959	Accident – aircraft	42		National Airlines Flight 967	Gulf of Mexico	Disappeared; suspected bombing
1966	Accident – aircraft	42		Braniff Flight 250	Richardson County, Nebraska
1973	Accident – explosion	42		1973 Staten Island gas explosion	Staten Island, New York
1977	Fire (building)	42		Maury County jail fire	Maury County, Tennessee	33 prisoners and 9 visitors killed
1998	Tornado outbreak	42		1998 Kissimmee tornado outbreak	Central Florida	Including the Intercession City–Port St. John tornado, which killed 25 people
1859	Bridge washout	41		South Bend train wreck	South Bend, Indiana
1909	Tropical cyclone	41		1909 Velasco hurricane	Texas
1914	Accident – shipwreck	41		SS Monroe (1902)	Off Virginia Capes
1924	Accident – iron mine	41		Milford Mine	Wolford Township, Crow Wing County, Minnesota
1950	Fire (building)	41		St. Elizabeth's Hospital fire	Davenport, Iowa
1968	Natural gas explosion	41		Richmond, Indiana explosion	Richmond, Indiana
1998	Tornado outbreak	41		Tornado outbreak of April 6–9, 1998	Midwestern United States, Eastern United States	Including the Birmingham Metro tornado, which killed 32 people
2001	Tropical cyclone	41	$8,500,000,000	Tropical Storm Allison	Texas, Louisiana, and Pennsylvania
2020	Tropical cyclone	41		Hurricane Laura	Louisiana, Texas, Florida

15 to 40 deaths

Year	Type	Fatalities	Damage (US$)	Article	Location	Comments
1901	Accident – shipwreck	40		SS Islander	Lynn Canal, Alaska
1906	Accident – shipwreck	40–54		Dix (steamboat)	Alki Point, Seattle, Washington
1927	Accident – shipwreck	40		USS S-4 (SS-109)	Off Cape Cod, Massachusetts
1932	Tropical cyclone	40		1932 Freeport hurricane	Texas
1933	Tropical cyclone	40		1933 Cuba–Brownsville hurricane	South Texas
1953	Tornado outbreak sequence	40	$26,713,000	April–May 1953 tornado outbreak sequence	Southeastern United States	Including 18 deaths from a tornado in Warner Robins, Georgia; also including four non-tornadic deaths
1962	Winter storm	40		Ash Wednesday Storm of 1962	East Coast of the United States
1969	Derecho	40+		Ohio Fireworks Derecho	Ohio
1994	Tornado outbreak	40	$140,000,000 (2005)	1994 Palm Sunday tornado outbreak	Southeastern United States	Including a single tornado which killed 22 people in northeastern Alabama
2008	Coal ash spill	40		Kingston Fossil Plant coal fly ash slurry spill	Kingston, Tennessee	An estimated 40 cleanup workers died due to various illnesses believed to be caused by coal ash exposure
1912	Accident – railroad	39		Corning train wreck	Corning, New York
1964	Accident – aircraft	39		United Airlines Flight 823	Near Parrottsville, Tennessee
1968	Accident – aircraft	39		Wien Consolidated Airlines Flight 55	Pedro Bay, Alaska
1970	Accident – coal mine	39		Hurricane Creek mine disaster	Hyden, Kentucky
1977	Accident – dam failure	39		Kelly Barnes Dam	Toccoa, Georgia
1997	Mass suicide	39		Heaven's Gate (religious group)	San Diego, California	Cult leaders Marshall Applewhite and Bonnie Nettles convinced followers they would join Comet Hale-Bopp to take them to another planet by swallowing poison.
1815	Tropical cyclone	38+		1815 New England hurricane	New England, Long Island
1846	Accident – shipwreck	38		John Minturn	Mantoloking, New Jersey
1860	Accident – shipwreck	38		SS Northerner	Centerville, Humboldt County, California
1886	Winter storm	38+		January 1886 blizzard	Eastern United States
1887	Bridge – railroad	38		Forest Hills disaster	Boston, Massachusetts
1920	Terrorism	38		Wall Street bombing	Manhattan, New York
1956	Tornado outbreak	38	$58,000,000	Tornado outbreak of April 2–3, 1956	Central United States	Including 17 deaths from the Saugatuck–Hudsonville–Standale, Michigan tornado
1964	Tropical cyclone, tornado	38		Hurricane Hilda	Louisiana	Including 22 deaths from a tornado near Larose, Louisiana
1967	Accident – aircraft	38		Lake Central Flight 527	Marseilles Township, Wyandot County, Ohio
1969	Accident – aircraft	38		United Airlines Flight 266	Santa Monica Bay, California
1973	Accident – aircraft	38		Ozark Air Lines Flight 809	Normandy, Missouri
2014	Tornado outbreak	38	≥$1,000,000,000 (2014)	Tornado outbreak of April 27–30, 2014	Southern United States, Central United States	84 tornadoes, including the Mayflower–Vilonia, Arkansas tornado which killed 16. 35 tornadic deaths, with another 3 from related weather.
2020	Tornado outbreak	38	$3,000,000,000 (2020)	2020 Easter tornado outbreak	Southeastern United States, Mid-Atlantic	Including six non-tornadic deaths
1883	Tornado	37	$700,000 (1883)	1883 Rochester tornado	Rochester, Minnesota	F5 tornado killed 37 and injured hundreds more. It led to the creation of the Mayo Clinic.
1948	Accident – aircraft	37		Northwest Airlines Flight 421	Fountain City, Wisconsin
1961	Accident – aircraft	37		Northwest Orient Airlines Flight 706	Chicago, Illinois
1966	Accident – shipwreck	37		Loss of MV Alva Cape	New York Harbor	33 people killed in first fire, four people killed in second fire several days later
1976	Accident – aircraft	37		American Airlines Flight 625	Saint Thomas, U.S. Virgin Islands
1994	Accident – aircraft	37		USAir Flight 1016	Charlotte, North Carolina
1846	Accident – shipwreck	36		USS Somers (1842)	Off Veracruz	Capsized due to a squall while chasing a blockade runner during the Mexican–American War
1887	Accident – shipwreck	36–50		SS Vernon	Lake Michigan
1918	Tornado	36		1918 Tyler tornado	Tyler, Minnesota
1924	Fire (building)	36	Financial damage not reported	Babbs Switch fire	Babbs Switch, Oklahoma	Christmas tree lighted with candles accidentally caught fire and destroyed school building. 37 additional people injured.
1937	Accident – airship	36		Hindenburg disaster	Manchester, New Jersey	Hydrogen-filled zeppelin exploded while trying to dock.
2002	Tornado outbreak	36	$160,000,000	Tornado outbreak of November 9–11, 2002	Eastern United States
2010	Flood, tornado outbreak	36	$2,300,000,000 (2010)	2010 Tennessee floods	Tennessee, Kentucky and Mississippi	Including five tornado deaths from a related tornado outbreak
2016	Fire (building)	36		Ghost Ship warehouse fire	Oakland, California
1900	Accident – railroad	35		Camp Creek train wreck	McDonough, Georgia
1907	Accident – coal mine	35+		Naomi Mine explosion	Fayette City, Pennsylvania
1914	Accident – shipwreck	35		Francis H. Leggett	Off Columbia Bar, Oregon
1919	Accident – shipwreck	35		J. A. Chanslor	Off Cape Blanco, Oregon
1949	Accident – aircraft	35		Standard Air Lines Flight 897R	Chatsworth, California
1969	Accident – aircraft	35		Hawthorne Nevada Airlines Flight 708	Lone Pine, California
1980	Ship – collision	35		Sunshine Skyway Bridge	St. Petersburg, Florida
1991	Accident – aircraft	35		Los Angeles runway disaster	Los Angeles, California
2007	Tornado outbreak, blizzard	35	$580,000,000	Tornado outbreak of February 28 – March 2, 2007	Central United States, Southern United States	20 deaths from tornadoes, 15 deaths from blizzard; four other deaths occurred in Canada
2011	Blizzard	35		2011 Halloween nor'easter	Northeastern United States	Additional four deaths in Canada
1878	Tornado	34	$5,300,000 (2007)	1878 Wallingford tornado	Southern Connecticut
1893	Tropical cyclone	34		1893 New York hurricane	Eastern United States
1916	Tropical cyclone	34+		1916 Gulf Coast hurricane	Gulf Coast of the United States
1920	Winter storm	34		1920 North Dakota blizzard	North Dakota
1922	Accident – airship	34		Roma (airship)	Norfolk, Virginia
1934	Fire (building)	34		Kerns Hotel fire	Lansing, Michigan
1936	Accident – shipwreck	34		SS Iowa (1920)	Columbia Bar, Washington
1943	Accident – shipwreck	34		USS Rogday (ID-3583)	Off South Carolina
1945	Accident – railroad	34		Michigan train wreck	Michigan City, North Dakota
1950	Accident – railroad	34		1950 Chicago streetcar crash	Chicago, Illinois
1959	Accident – aircraft	34		Braniff Flight 542	Near Buffalo, Texas
1960	Accident – aircraft	34		National Airlines Flight 2511	Near Bolivia, North Carolina
1967	Attack - military ship	34		USS Liberty incident	Mediterranean Sea	34 deaths on military ship USS Liberty due to the June 8, 1967, attack by Israeli Defense Force (IDF) aircraft and torpedo boats.
1967	Accident – aircraft	34		Mohawk Airlines Flight 40	Blossburg, Pennsylvania
1980	Accident – aircraft	34		Florida Commuter Airlines crash	Atlantic Ocean, near West End, Bahamas
2015	Tropical cyclone, shipwreck	34	$200,000,000	Hurricane Joaquin	Southeastern United States, Bermuda, Cuba, The Caribbean	Including 33 deaths from the sinking of SS El Faro near the Bahamas, and one other death on land.
2019	Fire (dive boat)	34		Sinking of MV Conception	Santa Cruz Island, California
1858	Accident – shipwreck	33		Eliza Battle	Tombigbee River, Alabama	Fatalities estimated
1913	Accident – explosion	33		Alum Chine explosion	Patapsco River, near Baltimore, Maryland
1925	Accident – shipwreck	33		USS S-51 (SS-162)	Near Block Island, Rhode Island
1941	Accident – shipwreck	33		USS O-9 (SS-70)	Off Portsmouth, New Hampshire
1952	Accident – aircraft	33		National Airlines Flight 101	Elizabeth, New Jersey	Last of three plane crashes in Elizabeth over three months
1958	Accident – shipwreck	33		SS Carl D. Bradley	Lake Michigan
1960	Tornado outbreak sequence	33	$32,618,000	May 1960 tornado outbreak sequence	Midwestern United States, Southern United States	Including 16 deaths from a single tornado in southeastern Oklahoma
1973	Flood	33		Mississippi flood of 1973	Mississippi Valley
1978	Tropical cyclone	33		Tropical Storm Amelia (1978)	Texas
1996	Accident – explosion	33		Humberto Vidal explosion	Río Piedras, Puerto Rico
2007	Mass murder – school shooting	33		Virginia Tech shooting	Blacksburg, Virginia	Armed with two semi-automatic handguns, student Seung-Hui Cho shot to death 32 people in two separate attacks on the campus of Virginia Polytechnic Institute and State University. 23 other people were wounded, 17 by gunfire. Cho committed suicide.
1858	Accident – shipwreck	32–33		John Milton (ship)	Off Long Island, New York
1868	Accident – shipwreck	32+		Morning Star (1862 ship)	Lake Erie	At least 30 deaths aboard the Morning Star, and two deaths aboard the Cortland
1918	Accident – shipwreck	32		USS Cherokee (ID-458)	Off Fenwick Island, Delaware	Including two people who later died after being rescued by the British Admiral
1948	Accident – aircraft	32		1948 Los Gatos DC-3 crash	Diablo Range, west of Coalinga, California
1948	Accident – aircraft	32		1948 Airborne Transport DC-3 disappearance	Atlantic Ocean, off east coast of Florida	Disappeared and was never recovered
1950	Accident – railroad	32		Rockville Centre train crash	Rockville Centre, New York
1962	Tornado outbreak sequence	32		Tornado outbreak sequence of May 14–June 1, 1962		Most fatalities were due to lightning rather than tornadoes
1963	Accident – bus, train	32		1963 Chualar bus crash	Chualar, California	Deadliest road accident in U.S. history, and deadliest U.S. rail accident involving a grade crossing
1968	Accident – aircraft	32		Northeast Airlines Flight 946	Etna, New Hampshire
1969	Tornado	32		1969 Hazlehurst, Mississippi tornadoes	Hazlehurst, Mississippi
1973	Fire (building)	32		UpStairs Lounge arson attack	New Orleans, Louisiana	Deadliest attack on a gay bar in the U.S. until 2016; still unsolved.
1994	Tropical cyclone	32		Tropical Storm Alberto (1994)	Georgia
1853	Accident – shipwreck	31		Steamboat Jenny Lind	San Francisco Bay, California
1855	Bridge – accident	31		Gasconade Bridge train disaster	Gasconade, Missouri
1862	Accident – shipwreck	31		USS Weehawken (1862)	Morris Island, South Carolina
1892	Accident – shipwreck	31		SS Western Reserve	Lake Superior
1910	Accident – shipwreck	31		USS Nina	Off Ocean City, Maryland
1913	Fire (building)	31		1913 Binghamton Factory fire	Binghamton, New York
1940	Accident – railroad	31		Little Falls Gulf Curve crash of 1940	Little Falls, New York	An additional 51 were injured
1959	Accident – aircraft	31		Capital Airlines Flight 75	Chase, Maryland
1970	Accident – aircraft	31		Wichita State University football team plane crash	Clear Creek County, Colorado
1981	Fire (building)	31		Keansburg nursing home fire	Keansburg, New Jersey	Nursing home full of elderly and mentally disabled
1983	Accident – shipwreck	31		SS Marine Electric	Off Virginia
1985	Accident – aircraft	31		Midwest Express Airlines Flight 105	Milwaukee, Wisconsin
1998	Flood	31		October 1998 Central Texas floods	Texas
2009	Tsunami	31		2009 Samoa earthquake and tsunami	American Samoa and nearby islands	189 total deaths, with 31 in American Samoa.
1845	Fire	30		Great New York City Fire of 1845	New York City, New York
1868	Earthquake	30		1868 Hayward earthquake	Hayward, California
1887	Structural failure	30		Forest Hills disaster	Boston, Massachusetts
1895	Accident – copper mine	30		Osceola Mine	Osceola Township, Houghton County, Michigan
1909	Accident – shipwreck	30–38		SS Marquette & Bessemer No. 2	Lake Erie
1923	Accident – railroad	30		Glenrock train wreck	Meadow Acres, Wyoming
1948	Accident – aircraft	30		Northwest Airlines Flight 4422	Mount Sanford, Alaska Territory
1952	Accident – aircraft	30		American Airlines Flight 6780	Elizabeth, New Jersey	Second of three plane crashes in Elizabeth over three months
1955	Accident – aircraft	30		American Airlines Flight 476	Fort Leonard Wood, Missouri
1956	Accident – railroad	30		Redondo Junction train wreck	Los Angeles, California
1965	Accident – aircraft	30		United Airlines Flight 389	Lake Michigan, near Lake Forest, Illinois
1982	Tornado outbreak	30	$390,500,000	Tornado outbreak of April 2–3, 1982	Midwestern United States, Southern United States
1987	Tornado	30	$2,500,000	1987 Saragosa tornado	Saragosa, Texas
1989	Tornado outbreak	30	$160,000,000 (2005)	November 1989 tornado outbreak	Southern United States, Eastern United States	21 deaths from the Huntsville, Alabama tornado; nine others from an event in Newburgh, New York variously described as either a tornado or a downburst
1997	Tornado outbreak	30	$126,600,000	1997 Central Texas tornado outbreak	Central Texas	All 27 tornadic deaths were from a single tornado in Jarrell; three other non-tornadic fatalities occurred
2004	Tropical cyclone	30		Hurricane Charley	Florida, Rhode Island
2005	Tropical cyclone	30		Hurricane Wilma	Florida
2006	Tornado outbreak	30	$1,100,000,000	Tornado outbreak of April 2, 2006	Midwestern United States, Mississippi River Valley	Including a single tornado in western Tennessee which killed 16; also including two non-tornadic deaths
2013	Tornado outbreak	30		Tornado outbreak of May 18–21, 2013	Moore, Oklahoma	Including the Moore, Oklahoma tornado which killed 24; also including four non-tornadic and indirect deaths
1871	Accident – railroad	29		Great Revere Train Wreck of 1871	Revere, Massachusetts
1910	Accident – shipwreck	29		SS Pere Marquette 18	Lake Michigan	Including two crew members of sister ship Pere Marquette 17
1910	Wildfire	29–42		Baudette fire of 1910	Beltrami County, Minnesota
1920	Accident – shipwreck	29		SS Superior City	Lake Superior	Collided with SS Willis L. King
1933	Wildfire	29		1933 Griffith Park fire	Griffith Park, California
1943	Accident – railroad	29		Lackawanna Limited wreck	Wayland, New York	Delaware, Lackawanna and Western Railroad passenger train sideswiped a freight train
1954	Tropical cyclone	29		Hurricane Edna	North Carolina, New England
1964	Accident – aircraft	29		Bonanza Air Lines Flight 114	Near Sloan, Nevada
1970	Fire (building)	29		Pioneer Hotel (Tucson, Arizona)	Tucson, Arizona
1971	Accident – explosion	29		Thiokol-Woodbine explosion	Woodbine, Georgia
1973	Accident – shipwreck	29		MV Norse Variant	Off New Jersey
1975	Accident – shipwreck	29		Wreck of the SS Edmund Fitzgerald	Lake Superior	Deadliest disaster on the Great Lakes. Inspired hit song by Gordon Lightfoot
1976	Accident – school bus	29		Yuba City bus disaster	Martinez, California
1977	Accident – aircraft	29		Air Indiana Flight 216	Evansville, Indiana	The University of Evansville basketball team was traveling to Middle Tennessee State University when the plane crashed 90 seconds after takeoff from Dress Regional Airport.
1990	Tornado	29	$160,000,000	1990 Plainfield tornado	Plainfield, Illinois Crest Hill, Illinois
1997	Accident – aircraft	29		Comair Flight 3272	Raisinville Township, Michigan
2007	Blizzard	29	$50,000,000	February 2007 North American blizzard	Midwestern United States, Eastern United States, Gulf Coast of the United States	Including one death due to a tornado in New Orleans; at least seven other deaths also occurred in Canada
2010	Accident – coal mine	29		Upper Big Branch Mine disaster	Montcoal, West Virginia
1913	Fire (building)	28		Arcadia Hotel fire	Boston
1927	Accident – explosion	28		Pittsburgh gasometer explosion	Pittsburgh, Pennsylvania
1949	Accident – aircraft	28		American Airlines Flight 157	Dallas, Texas
1951	Flood	28	$7,000,000,000 (2005)	Great Flood of 1951	Kansas, Missouri
1953	Accident – aircraft	28		American Airlines Flight 723	Colonie, New York
1958	Tornado outbreak	28	$83,275,000	Tornado outbreak of June 3–4, 1958	Minnesota, Montana, Nebraska, Wisconsin	Including 21 deaths from a tornado that struck Colfax, Wisconsin
1959	Earthquake	28+		1959 Hebgen Lake earthquake	Montana
1961	Structural collapse	28		Texas Tower 4	Off the coast of Long Island, New York	USAF radar station which sunk due to the January 1961 nor'easter
1968	Accident – aircraft	28		North Central Airlines Flight 458	Chicago, Illinois
1969	Accident – fire, explosion	28		USS Enterprise fire	Pacific Ocean, off Pearl Harbor, Hawaii
1971	Accident – aircraft	28		Allegheny Airlines Flight 485	New Haven, Connecticut
1977	Winter storm	28		Blizzard of 1977	New York
1987	Structural collapse	28		L'Ambiance Plaza collapse	Bridgeport, Connecticut
1987	Accident – aircraft	28		Continental Airlines Flight 1713	Denver, Colorado
1998	Winter storm, flood	28		January 1998 North American ice storm	Eastern United States	Additional 28 deaths in Canada
2008	Tornado outbreak sequence	28	$250,324,000	Tornado outbreak sequence of May 7–15, 2008	Southern Plains, Southeastern United States, Mid-Atlantic	Including the Picher, Oklahoma/Neosho, Missouri tornado which killed 21 people; also including three non-tornadic deaths
2012	Mass murder – school shooting	28		Sandy Hook Elementary School shooting	Sandy Hook, Connecticut	Adam Lanza shot and killed his mother, then drove to Sandy Hook Elementary School, where he fatally shot 20 students and 6 educators before committing suicide.
1872	Earthquake	27		1872 Owens Valley earthquake	Owens Valley, California
1947	Accident – coal mine	27		West Frankfort, Illinois	West Frankfort, Illinois
1958	Accident – school bus	27		Prestonsburg, Kentucky bus disaster	Prestonsburg, Kentucky
1962	Accident – aircraft	27		Canadian Pacific Air Lines Flight 301	Honolulu, Hawaii
1984	Accident – coal mine	27		Wilberg Mine	Emery County, Utah
1988	Accident – school bus	27		Carrollton bus collision	Carrollton, Kentucky
1992	Accident – aircraft	27		USAir Flight 405	Flushing Bay, near Queens, New York
1996	Tropical cyclone	27		Hurricane Fran	The Carolinas, the Virginias, Pennsylvania
1997	Tornado outbreak	27	$115,000,000	March 1997 tornado outbreak	Arkansas, Mississippi, Kentucky, and Tennessee	Including a single tornado which killed 15 people near Little Rock, Arkansas
2003	Winter storm	27		North American blizzard of 2003	Rocky Mountains, Central United States, Eastern United States
2013	Tornado outbreak, flood	27		Tornado outbreak of May 26–31, 2013	Oklahoma, Kansas, Missouri, Arkansas	9 tornadic deaths, 18 from flooding and other causes
2017	Mass shooting	27		Sutherland Springs church shooting	Sutherland Springs, Texas	26 murdered, gunman committed suicide after being mortally wounded by an armed civilian
1863	Accident – shipwreck	26		SS Ada Hancock	San Pedro Bay, California
1911	Stampede	26		Canonsburg Opera House disaster	Canonsburg, Pennsylvania
1913	Accident – explosion, shipwreck	26		James T. Staples	Tombigbee River, near Coffeeville, Alabama
1924	Accident – shipwreck	26		SS Clifton	Lake Huron
1926	Accident – shipwreck	26		SS Papoose	Mississippi River
1939	Accident – shipwreck	26		USS Sailfish (SS-192)	Off New Hampshire
1951	Accident – aircraft	26		Continental Charters Flight 44-2	Near Napoli, New York
1959	Accident – aircraft	26		Piedmont Airlines Flight 349	Albemarle County, Virginia
1962	Tropical cyclone	26		Hurricane Daisy (1962)	New England
1967	Accident – aircraft	26		TWA Flight 553	Concord Township, Champaign County, Ohio
1970	Tornado outbreak sequence	26		Tornado outbreak sequence of April 17–19, 1970	Midwestern United States, Southern United States	Including a tornado which killed 16 people in the Texas Panhandle
1970	Tornado	26	$1,411,900,000 (2008)	Lubbock tornado	Lubbock, Texas	F5 tornado killed 26 and wounded approximately 500
1976	Accident – coal mine	26		Scotia Mine	Oven Fork, Kentucky
1980	Fire (building)	26		Stouffer's Inn fire	Harrison, New York
1992	Tornado outbreak	26	$300,000,000	Tornado outbreak of November 1992	Southeastern United States, Ohio Valley
2008	Accident – railroad	26		2008 Chatsworth train collision	Chatsworth, California
2020	Tornado outbreak	26	$1,606,000,000 (2020)	Tornado outbreak of March 2–3, 2020	Tennessee, Alabama, Kentucky, Missouri	Including the Putnam County, Tennessee tornado which killed 19; also including one indirect fatality
1898	Accident – shipwreck	25–40		Hassler (vessel)	North of Eldred Rock, Alaska
1913	Accidental shipwreck – lake freighter – storm	25		SS Henry B. Smith	Lake Superior	The SS Henry B. Smith was taking iron ore from one side of Lake Superior to the other. The weather became below freezing with powerful storms which caused massive waves, which resulted in her sinking, killing all 25 crew members on the ship.
1916	Accident – shipwreck	25		SS James B. Colgate	Lake Erie
1926	Tropical cyclone	25		1926 Nassau hurricane	Puerto Rico
1926	Tropical cyclone	25		1926 Louisiana hurricane	Louisiana
1929	Accident – shipwreck	25		SS Andaste	Lake Michigan
1936	Flood	25		Johnstown flood of 1936	Johnstown, Pennsylvania area
1940	Accident – aircraft	25		Lovettsville air disaster	Lovettsville, Virginia
1956	Tornado	25		1956 McDonald Chapel tornado	Jefferson County, Alabama
1958	Accident – aircraft	25		Northeast Airlines Flight 258	Nantucket Memorial Airport, Massachusetts
1959	Accident – aircraft	25		Allegheny Airlines Flight 371	South Williamsport, Pennsylvania
1962	Accident – aircraft	25		Eastern Air Lines Flight 512	New York City, New York
1982	Fire (building)	25		Dorothy Mae Apartments	Los Angeles, California	Arson fire killed 19 residents on scene, 6 others died later from injuries.
1986	Accident – aircraft	25		Grand Canyon Airlines Flight 6	Grand Canyon National Park, Arizona	Deadliest accident involving a helicopter in U.S. history
1991	Fire (building)	25		Hamlet chicken processing plant fire	Hamlet, North Carolina	Workers trapped behind locked doors
1991	Wildfire (wildland-urban interface)	25	$1,500,000,000	1991 Oakland firestorm	Oakland, California, and vicinity	Burned 2,900 structures and 1,500 acres in Oakland Hills
2005	Tornado	25	$92,000,000	Evansville Tornado of November 2005	Missouri, Indiana, Kentucky, Ohio	7 tornadoes
1806	Tropical cyclone, shipwreck	24		1806 Great Coastal hurricane	East Coast of the United States	Including 21 deaths in the wreck of the Rose-in-Bloom off Barnegat Inlet, New Jersey, and three deaths in or offshore from North Carolina
1854	Accident – explosion	24+		Gazelle (1854 sidewheeler)	Canemah, Oregon
1881	Tornado outbreak	24		1881 Minnesota tornado outbreak	Southern Minnesota	Including 20 deaths from a single tornado
1901	Accident – shipwreck	24–25		SS Hudson (1887)	Off Eagle Harbor, Michigan
1905	Accident – coal mine	24		Red Ash Mine disasters	Fire Creek, West Virginia	Two explosions over two days killed a total of 24 people
1908	Accident – shipwreck	24		SS D.M. Clemson	Lake Superior
1939	Accident – railroad	24		1939 City of San Francisco derailment	Harney, Nevada
1944	Accident – aircraft	24		American Airlines Flight 2	Mississippi River
1958	Fire (building)	24		Monarch Underwear Company fire	New York City, New York
1974	Arson	24		Gulliver's nightclub fire	Port Chester, New York
1980	Tropical cyclone	24		Hurricane Allen	Texas, Louisiana	7 deaths in Texas, 17 offshore deaths in Louisiana
1991	Mass murder	24		Luby's shooting	Killeen, Texas	23 murdered, gunman committed suicide
1994	Accident – aircraft	24		Green Ramp disaster	Fayetteville, North Carolina	Deadliest aircraft accident in the U.S. involving victims on the ground
1995	Accident – aircraft	24		1995 Alaska Boeing E-3 Sentry accident	Elmendorf Air Force Base, Alaska
2002	Winter storm	24		North Carolina ice storm of 2002	North Carolina
2015	Extratropical cyclone	24		October 2015 North American storm complex	Eastern United States	Additional death in New Brunswick
1891	Accident – railroad	23		Railway accident on the Bostian Bridge	Statesville, North Carolina
1900	Structural collapse	23		Thanksgiving Day Disaster	San Francisco, California	Deadliest sporting event accident in US history
1919	Accident – railroad	23		Onawa train wreck	Onawa, Maine
1923	Accident – shipwreck	23		Honda Point disaster	Near Lompoc, California	20 deaths aboard USS Young, three deaths aboard USS Delphy
1925	Accident – shipwreck	23		M.E. Norman	Mississippi River
1933	Tropical cyclone	23–25		1933 Outer Banks hurricane	North Carolina, Virginia	Two people went missing in Maine
1950	Accident – shipwreck	23		USS Benevolence	Off San Francisco, California
1959	Explosion – fire	23		Meldrim, Georgia, trestle disaster	Meldrim, Georgia
1961	Tornado outbreak sequence	23	$42,205,000	Tornado outbreak sequence of May 3–9, 1961	Great Plains, Mississippi Valley, Midwest, Northeastern, Mid-Atlantic, and Southeastern United States	Including 16 deaths from a tornado in Le Flore County, Oklahoma
1962	Accident – explosion	23		New York Telephone Company building explosion	New York City, New York
1965	Accident – aircraft	23		USAF KC-135 Wichita crash	Wichita, Kansas
1968	Accident – aircraft	23		Los Angeles Airways Flight 841	Paramount, California
1970	Accident – aircraft	23		ALM Flight 980	Caribbean Sea, off Saint Croix
1970	Tropical cyclone	23		Hurricane Celia	Texas, Florida
1970	Tropical cyclone, flood	23		Tropical Storm Norma (1970)	Arizona
1976	Arson	23		Wincrest Nursing Home fire	Chicago, Illinois
1976	Fire (building)	23		Pathfinder Hotel fire	Fremont, Nebraska	Explosion caused by natural gas leak in the hotel basement ignited the fire and shattered windows in neighboring buildings.
1977	Blizzard	23	$56,250,000 (1977)	Great Lakes Blizzard of 1977	New York, Ontario	The brunt of the blizzard was centered around Buffalo.
1980	Accident – shipwreck	23		USCGC Blackthorn	Tampa Bay, Florida
1983	Accident – aircraft	23		Air Canada Flight 797	Cincinnati, Ohio
1989	Accident – explosion	23	$1,415,000,000 (1990)	Phillips disaster	Pasadena, Texas	314 people injured
1991	Accident – aircraft	23		Atlantic Southeast Airlines Flight 2311	Brunswick, Georgia
2016	Flood	23+		2016 West Virginia flood	West Virginia and Virginia
2019	Tornado	23		Tornado outbreak of March 3, 2019	Alabama and Georgia	All 23 fatalities due to a single tornado; 3 of the deaths were children
2019	Mass shooting	23		2019 El Paso shooting	El Paso, Texas
2021	Winter storm	23		February 15–20, 2021 North American winter storm	Contiguous United States	Additional six deaths in Mexico
1821	Tropical cyclone	22+		1821 Norfolk and Long Island hurricane	East Coast of the United States
1865	Tornado	22		1865 Viroqua tornado	Viroqua, Wisconsin
1893	Structural collapse	22		Ford's Theatre	Washington, D.C.
1895	Accident – shipwreck	22		SS Chicora	Lake Michigan
1907	Accident – shipwreck	22		SS Cyprus	Lake Superior
1903	Accident – explosion	22		United States Cartridge Company explosion	Lowell, Massachusetts
1929	Fire (building)	22		Study Club fire	Detroit, Michigan
1942	Accident – aircraft	22		TWA Flight 3	Potosi Mountain, southwest of Las Vegas, Nevada	Among those killed were actress Carole Lombard and her mother, who were returning to Los Angeles after a war bond drive in their home state of Indiana.
1953	Tornado outbreak	22	$6,835,000	Mid–March 1953 tornado outbreak	Great Plains, Mississippi Valley, Southeastern United States	Including 17 deaths from a tornado in northern Texas
1956	Accident – aircraft	22		TWA Flight 400	Moon Township, Allegheny County, Pennsylvania
1959	Tornado outbreak	22	$53,713,000	St. Louis tornado outbreak of February 1959	Great Plains, Midwestern United States, Southeastern United States	21 deaths from a single tornado in St. Louis, Missouri, and one death from flooding
1959	Tropical cyclone, tornado outbreak	22		Hurricane Gracie	Georgia, South Carolina, Virginia	Including 12 deaths from a tornado outbreak in Virginia
1960	Accident – aircraft	22		Cal Poly football team plane crash	Toledo, Ohio
1963	Fire (building)	22		Hotel Roosevelt fire	Jacksonville, Florida
1972	Accident – aircraft	22		1972 Sacramento Canadair Sabre accident	Sacramento, California
1974	Tornado outbreak	22		Tornado outbreak of June 8, 1974	Midwestern United States, Southern United States
1979	Tropical cyclone	22		Hurricane David	Puerto Rico, East Coast of the United States
1980	Accident – tour bus	22			Jasper, Arkansas
1984	Mass shooting, hostage taking	22		San Ysidro McDonald's massacre	San Ysidro, California	James Huberty entered a McDonald's armed with multiple Firearms, and shot dead 21 people before being killed by police.
1991	Winter storm	22		1991 Halloween blizzard	Central United States
1999	Accident – tour bus	22			New Orleans, Louisiana	Plunged over embankment, carrying senior citizens from casino
2012	Derecho	22		June 2012 North American derecho	Midwestern United States, Mid-Atlantic United States
2014	Winter storm	22		February 2014 nor'easter	Eastern United States
2015	Tropical cyclone	22		Hurricane Linda (2015)	Utah, California
2017	Tornado outbreak	22	$1,300,000,000 (2017)	Tornado outbreak of January 21–23, 2017	Southeastern United States, Northeastern United States	Including two non-tornadic deaths
2017	Wildfire	22		Tubbs Fire	Napa and Sonoma County, California	Wildfire burned 36,807 acres and 5,636 structures.
2018	Blizzard	22		January 2018 North American blizzard	Eastern United States
2022	Mass murder – school shooting	22		Robb Elementary School shooting	Uvalde, Texas	Including the perpetrator
1889	Accident – shipwreck	21+		Alaskan (sidewheeler)	Oregon
1903	Accident – railroad	21		1903 East Paris train wreck	Kentwood, Michigan
1905	Accident – railroad	21		20th Century Limited derailment	Mentor, Ohio
1910	Bombing	21		Los Angeles Times bombing	Los Angeles, California
1910	Fire, structural failure	21		Chicago Union Stock Yards fire	Chicago, Illinois
1915	Accident – shipwreck	21		USS F-4	Off Honolulu, Hawaii
1915	Fire (building)	21		St. Johns School fire	Peabody, Massachusetts	Schoolgirls trapped behind exit door; resulted in first city law requiring that exit doors open outward
1919	Accident – explosion	21	$6,600,000,000 (2005)	Great Molasses Flood	Boston, Massachusetts	Damages are out-of-court settlements only; repairs took 133 man-months
1953	Accident – railroad	21		1953 New York Central Railroad accident	Conneaut, Ohio
1957	Tornado outbreak sequence	21	$9,500,000	Early-April 1957 tornado outbreak sequence	Central United States, Eastern United States
1959	Fire (building)	21		Arkansas Negro Boys' Industrial School	Wrightsville, Arkansas
1968	Accident – aircraft	21		Los Angeles Airways Flight 417	Compton, California
1983	Tropical cyclone	21		Hurricane Alicia	Texas
1986	Accident – tour bus	21			Walker, California
1987	Winter storm, shipwrecks	21		February 1987 nor'easter	Mid-Atlantic United States	18 deaths on MV Balsa 24, and 3 deaths on the Delores Marie
1989	Motor vehicle accident	21		Alton, Texas bus crash	Alton, Texas
1991	Tornado outbreak	21	$250,000,000	Andover tornado outbreak	Great Plains	Including one tornado which killed 17 people near Andover, Kansas
2003	Accident – aircraft	21		Air Midwest Flight 5481	Charlotte, North Carolina
2003	Stampede	21		2003 E2 nightclub stampede	Chicago, Illinois
2007	Tornado outbreak	21	$218,000,000	2007 Groundhog Day tornado outbreak	Central Florida
2007	Tropical cyclone	21		Tropical Storm Erin (2007)	Texas, Oklahoma, Missouri
2008	Tropical cyclone	21		Tropical Storm Fay (2008)	Puerto Rico, Southeastern United States
2009	Winter storm	21		2009 North American Christmas blizzard	Midwest, Great Plains, Eastern United States
2014	Cold wave	21		Early 2014 North American cold wave	Central United States, Eastern United States
2018	Debris flow	21–23		2018 Southern California mudflows	Southern California	163 injured. 65 residences destroyed, 462 residences damaged, 8 commercial buildings destroyed, 20 commercial buildings damaged
1860	Accident – shipwreck	20		USCS Robert J. Walker (1844)	Off New Jersey
1872	Fire (urban conflagration)	20	$73,500,000 (1872)	Great Boston fire of 1872	Boston, Massachusetts
1874	Fire (urban conflagration)	20		Chicago Fire of 1874	Chicago, Illinois
1881	Tornado outbreak	20+		Tornado outbreak of June 1881	West North Central States
1882	Accident – shipwreck	20		SS Escambia	San Francisco, California
1890	Accident – railroad	20		1890 Quincy train wreck	Quincy, Massachusetts
1907	Accident - Explosion	20-24	$100,000 (1907)	Standard Steel Mill Explosion	Butler, Pennsylvania
1907	Accident – railroad	20		Woodlawn derailment	Woodlawn, The Bronx, New York City	The day after the New York Central Railroad inaugurated electrical train service in New York City and suburban Westchester County, an electric engine (which had a higher center of mass than the old steam engines) jumped the tracks on a curve leading into Woodlawn station. Wreckage was strewn over a mile (1.6 km) with 20 dead and 150 injured.
1916	Accident – shipwreck	20		SS S.R. Kirby	Off Eagle Harbor, Michigan
1916	Tropical cyclone	20		1916 Texas hurricane	Texas
1924	Accident – explosion	20		1924 Nixon Nitration Works disaster	Nixon, New Jersey
1928	Accident – explosion	20		Preble Box Toe Company explosion	Lynn, Massachusetts
1943	Accident – aircraft	20		American Airlines Flight 63 (Flagship Ohio)	Allen County, Kentucky
1948	Smog	20		1948 Donora smog	Donora, Pennsylvania
1957	Accident – aircraft	20		Northeast Airlines Flight 823	Queens, New York
1968	Accident – aircraft	20		Allegheny Airlines Flight 736	Bradford, Pennsylvania
1969	Winter storm	20+		December 1969 nor'easter	Northeastern United States
1978	Fire (building)	20		Coates House Hotel	Kansas City, Missouri
2005	Accident – shipwreck	20		Ethan Allen boating accident	Lake George (New York)	Overloaded tour boat capsized from another boat's wake.
2005	Accident – aircraft	20		Chalk's Ocean Airways Flight 101	Off Miami Beach, Florida
2008	Tornado outbreak sequence, flood	20	$146,900,000	Tornado outbreak sequence of June 3–11, 2008	Central United States, Eastern United States	7 tornado deaths, 13 from other events (see also June 2008 Midwest floods)
2010	Flood	20		June 2010 Arkansas floods	Albert Pike Recreation Area near Langley, Arkansas
2011	Flood	20		2011 Mississippi River floods	Mississippi River Valley
2017	Tornado outbreak, flood	20		Tornado outbreak and floods of April 28 – May 1, 2017	High Plains, Western United States (Rocky Mountains), Ohio Valley, Upper Midwest, Southeastern United States	5 deaths from tornadoes, 15 from other causes
2018	Motor vehicle accident	20		Schoharie limousine crash	Schoharie, New York	Stretch limo ran a stop sign on a three-way intersection, killing all 18 inside and two people in a parking lot
2021	Flood	20		2021 Tennessee floods	Middle Tennessee
1863	Accident – shipwreck	19		CSS Chattahoochee	Apalachicola River
1878	Accident – railroad	19		Wollaston disaster	Quincy, Massachusetts
1888	Accident – shipwreck	19		SS City of Chester	Golden Gate, California
1897	Accident – railroad	19		Garrison train crash	Garrison, New York
1908	Fire (urban conflagration)	19		Great Chelsea fire of 1908	Chelsea, Massachusetts
1917	Accident – shipwreck	19		USS F-1	Off Point Loma, San Diego, California
1943	Accident – aircraft	19		Pan Am Flight 1104	Mendocino County, California
1943	Tropical cyclone	19		1943 Surprise Hurricane	Louisiana, Texas
1944	Accident – aircraft	19		Long Creek air disaster	South Portland, Maine
1944	Accident – aircraft	19		US Army C-47 crash	Mount Deception (Alaska)
1950	Accident – aircraft	19		1950 Fairfield-Suisun Boeing B-29 crash	Fairfield-Suisun Air Force Base, California
1953	Accident – aircraft	19		BCPA Flight 304	Near Woodside, California
1956	Fire (industrial)	19		McKee refinery fire	Near Sunray, Texas
1957	Tornado outbreak sequence	19		Tornado outbreak sequence of December 18–20, 1957	Midwestern United States, Southern United States
1962	Tornado outbreak	19	$3,380,000	Tornado outbreak of March 30–31, 1962	Southeastern United States	Including 17 deaths from a single tornado in Milton, Florida and two lightning deaths
1964	Flood	19		Christmas flood of 1964	Pacific Northwest
1969	Accident – aircraft	19		Prinair Flight 277	Fajardo, Puerto Rico
1970	Tropical cyclone	19		Tropical Depression Fifteen (1970)	Puerto Rico, U.S. Virgin Islands
1974	Accident – bus	19		1974 Blythe, California bus crash	Ripley, California
1992	Winter storm	19		December 1992 nor'easter	Northeastern United States
1996	Tropical cyclone	19		Hurricane Hortense	Puerto Rico
2000	Accident – aircraft	19		2000 Marana V-22 crash	Near Tucson, Arizona
2000	Accident – aircraft	19		2000 East Coast Aviation Services British Aerospace Jetstream crash	Wilkes-Barre, Pennsylvania
2000	Terrorism	19		USS Cole bombing	Aden, Yemen	Including the two perpetrators
2013	Wildfire	19		Yarnell Hill Fire	Yarnell, Arizona	19 firefighters were killed when they became trapped in the fast-spreading fire.
1887	Accident - mine explosion	18			Savanna, Oklahoma (then Choctaw Nation in Indian Territory)	Explosions in Savanna Coal Mining and Trading Company Mines #1 and #2 killed 6 miners and 12 rescuers.
1892	Accident – shipwreck	18		SS W.H. Gilcher	Lake Michigan
1911	Accident – railroad	18		Indianola train wreck	Indianola, Nebraska
1928	Accident – railroad	18		1928 Times Square derailment	New York City, New York
1947	Accident – aircraft	18		Eastern Air Lines Flight 665	Galax, Virginia
1947	Accident – aircraft	18		Pan Am Flight 923	Annette Island, Alaska Territory
1960	Tropical cyclone	18		1960 Texas tropical storm	Texas, Arkansas
1961	Accident – aircraft	18		United Airlines Flight 859	Denver, Colorado
1966	Tornado outbreak sequence	18	$250,603,000	Tornado outbreak sequence of June 1966	Southern United States, Midwestern United States, Great Plains	Including 16 deaths from a single tornado in Topeka, Kansas
1966	Mass murder – school shooting	18		University of Texas massacre	Austin, Texas	Including the perpetrator and an unborn child
1966	Accident – aircraft	18		West Coast Airlines Flight 956	Clackamas County, Oregon
1993	Accident – aircraft	18		Northwest Airlink Flight 5719	Hibbing, Minnesota
2000	Tornado outbreak	18		Tornado outbreak of February 13–14, 2000	Southeastern United States
2001	Accident – aircraft	18		2001 Avjet Gulfstream III crash	Pitkin County, Colorado
2006	Extratropical cyclone	18		Hanukkah Eve windstorm of 2006	Washington, Oregon
2007	Flood	18		2007 Midwest flooding	Midwestern United States
2011	Tropical cyclone	18		Tropical Storm Lee (2011)	Gulf Coast of the United States, Eastern United States
2013	Blizzard	18		Early February 2013 North American blizzard	Eastern United States
2015	Tornado outbreak	18	$1,606,000,000 (2020)	Tornado outbreak of December 23–25, 2015	Mississippi, Tennessee, Indiana, Illinois, Alabama	Including five non-tornadic deaths
1861	Accident – railroad	17–20		Platte Bridge Railroad Tragedy	St. Joseph, Missouri
1898	Accident – shipwreck	17		SS L.R. Doty	Lake Michigan
1903	Accident – railroad	17		Purdue Wreck	Indianapolis, Indiana
1905	Accident – railroad	17		Baker Bridge train wreck	Lincoln, Massachusetts
1910	Accident – explosion	17		Morewood Lake Ice Company explosion	Pittsfield, Massachusetts
1919	Accident – shipwreck	17		SS Myron	Lake Superior
1923	Accident – collapse	17–35+		Allen Street Bridge disaster	Cowlitz River, Washington	Fatalities estimated
1936	Accident – aircraft	17		American Airlines Flight 1 (1936)	Near Goodwin, Arkansas
1944	Accident – shipwreck	17		USS YF-415	Hingham, Massachusetts	Including one person who died of his injuries after being rescued
1947	Accident – explosion	17		O'Connor Plating Works disaster	Los Angeles, California
1950	Tropical cyclone	17		Hurricane Dog (1950)	East Coast of the United States	Including three deaths in a car accident in Bel Air, Maryland, two drowning deaths in Lexington, Virginia, and 12 deaths in New England
1951	Flood	17		Great Flood of 1951	Kansas, Missouri
1951	Tropical cyclone, shipwreck	17		Hurricane How	Cape Hatteras, North Carolina	17 people were killed in the wreck of the Southern Isle
1953	Accident – shipwreck	17		SS Henry Steinbrenner	Lake Superior
1954	Tropical cyclone	17		Hurricane Alice (June 1954)	Texas
1962	Accident – aircraft	17		United Airlines Flight 297	Near Ellicott City, Maryland
1965	Accidents – pipeline accidents	17		Pipeline explosion and fire	Natchitoches, Louisiana
1965	Tornado outbreak	17	$51,000,000	Early May 1965 tornado outbreak	Great Plains, Midwestern United States
1968	Accident – shipwreck	17		USCGC White Alder (WLM-541)	Mississippi River, near White Castle, Louisiana
1972	Accident – aircraft	17		Mohawk Airlines Flight 405	Albany, New York
1979	Accident – aircraft	17		Downeast Flight 46	Rockland, Maine
1984	Accident – explosion	17		1984 Romeoville petroleum refinery disaster	Romeoville, Illinois
1986	Tornado outbreak	17	$25,000,000	Tornado outbreak of March 10–12, 1986	Central United States, Eastern United States, Southern United States
1990	Accident – explosion	17		1990 ARCO explosion	Channelview, Texas
1991	Accident – automobile	17		Interstate 5 dust storm accident	Coalinga, California
2002	Mass murder serial killings	17		Beltway sniper attacks	Washington metropolitan area	3 injured in the Beltway sniper attacks and 7 in preliminary shootings
2004	Winter storm	17		December 21–24, 2004 North American winter storm	South Central United States, Ohio Valley	Additional death in Canada
2005	Flood	17		Los Angeles County flood of 2005	Los Angeles County, California	Including 10 deaths in the La Conchita landslide
2008	Flood	17		Early Spring 2008 Midwest floods	Central United States
2008	Accident – bus	17		Sherman, Texas bus accident	Sherman, Texas
2018	School shooting	17		Stoneman Douglas High School shooting	Parkland, Florida	Former student Nikolas Cruz, was dropped off by an Uber car to Stoneman Douglas High School, shot and killed 14 students and 3 staff members, left the scene and was later arrested in Coral Springs.
2018	Accident – shipwreck	17		Table Rock Lake duck boat accident	Branson, Missouri
2022	Fire (building)	17		2022 Bronx apartment fire	The Bronx, New York City, New York
1804	Tropical cyclone	16		1804 New England hurricane	New England
1833	Accident – explosion, shipwreck	16		Lioness (steamship)	Near Colfax, Louisiana
1862	Accident – shipwreck	16		USS Monitor	Off Cape Hatteras, North Carolina
1890	Tornado	16		1890 Wilkes-Barre tornado	Wilkes-Barre, Pennsylvania
1905	Accident – shipwreck	16		SS Kaliyuga	Lake Huron
1914	Accident – shipwreck	16–20		SS Benjamin Noble	Near Knife River, Minnesota
1926	Tornado	16		La Plata tornado of 1926	La Plata, Maryland	13 killed in La Plata Elementary School
1947	Wildfires	16		Great Fires of 1947	Maine
1955	Accident – aircraft	16		TWA Flight 260	Bernalillo County, New Mexico
1956	Tropical cyclone	16		Hurricane Betsy (1956)	Puerto Rico
1956	Accident – explosion	16		Lariat Cafe explosion	Monticello, Utah
1967	Tropical cyclone	16		Hurricane Beulah	Puerto Rico, Texas
1970	Wildfire	16		Laguna Fire	Laguna Mountains, California
1978	Accident – railroad	16		Waverly, Tennessee, tank car explosion	Waverly, Tennessee	An additional 43 injured
1978	Tornado, shipwreck	16		1978 Whippoorwill tornado	Pomona Lake, Kansas	Tornado struck a tourist boat, causing it to capsize
1987	Accident – railroad	16		1987 Maryland train collision	Chase, Maryland
1987	Mass murder spree killer	16		The Dover massacre	Dover, Arkansas – Russellville, Arkansas
1991	Tropical cyclone	16		Hurricane Bob	East Coast of the United States
2006	Flood	16		2006 Mid-Atlantic United States flood	Mid-Atlantic United States
2012	Tornado outbreak, blizzard	16	$150,000,000	Late December 2012 North American storm complex	Alaska, Contiguous United States
2015	Terrorism	16		2015 San Bernardino attack	San Bernardino, California	An additional 24 injured
2016	Accident – hot air balloon	16		2016 Lockhart hot air balloon crash	Lockhart, Texas	Deadliest ballooning disaster in U.S. history
2017	Blizzard	16–19		March 2017 North American blizzard	Northeastern United States, Upper Midwest, Great Plains
2017	Accident – aircraft	16		2017 United States Marine Corps KC-130 crash	Leflore County, Mississippi
2020	Wildfire	16		North Complex fire	Plumas National Forest, California
2021	Tornado outbreak sequence	16	$3,200,000,000	Tornado outbreak sequence of March 24–28, 2021	Southeastern United States	Including one indirect and eight non-tornadic deaths
1815	Tropical cyclone	15		1815 North Carolina hurricane	North Carolina
1881	Accident – shipwreck	15		City of Muskegon	Lake Michigan
1883	Accident – railroad	15		1883 Tehachapi train wreck	Tehachapi, California
1902	Accident – railroad	15		Park Avenue main line	New York City, New York
1917	Tropical cyclone	15		1917 Nueva Gerona hurricane	Louisiana, Florida	10 in Louisiana, 5 in Florida
1936	Accident – shipwreck	15		MV Material Service	Lake Michigan
1937	Wildfire	15		Blackwater Fire of 1937	Shoshone National Forest, Wyoming
1948	Flood	15		Vanport flood	Vanport, Oregon
1950	Accident – aircraft	15		Northwest Orient Airlines Flight 307	Minneapolis, Minnesota
1953	Wildfire	15		Rattlesnake Fire	Mendocino National Forest, California
1954	Fire (building)	15		Cleveland Hill Middle School fire	Cheektowaga, New York
1955	Accident – aircraft	15		1955 Cincinnati mid-air collision	Boone County, Kentucky
1956	Tropical cyclone	15		Hurricane Flossy (1956)	Gulf Coast of the United States, East Coast of the United States
1969	Accident – aircraft	15		Scandinavian Airlines System Flight 933	Santa Monica Bay, near Los Angeles, California
1969	Tornado outbreak	15	$4,270,000	Tornado outbreak of August 6, 1969	Minnesota, Nebraska
1984	Arson	15		Beverly rooming house fire	Beverly, Massachusetts
1986	Mass murder	15		Edmond post office shooting	Edmond, Oklahoma	14 victims and 1 perpetrator
1994	Accident – aircraft	15		Flagship Airlines Flight 3379	Morrisville, North Carolina
1999	Mass murder – school shooting	15		Columbine High School massacre	Jefferson County, Colorado	Armed with 2 sawed-off shotguns, a TEC-9 pistol and a carbine, Eric Harris and Dylan Klebold entered their school in Littleton and opened fire at the students and staff, killing 12 students, 1 teacher and then killing themselves.
2003	Wildfire	15		Cedar Fire	San Diego County, California	Burned 273,246 acres and 2,820 structures
2005	Accident – explosion	15		Texas City Refinery explosion	Texas City, Texas
2005	Tropical cyclone	15		Hurricane Dennis	Florida, Alabama, Mississippi
2009	Tornado outbreak	15	$18,100,000	Tornado outbreak of February 10–11, 2009	Central United States, Eastern United States	Including seven non-tornadic deaths
2011	Accident – tour bus	15		World Wide Tours bus crash	Bronx, New York	En route to Connecticut casino, March 12
2012	Tornado outbreak	15	$475,000,000	2012 Leap Day tornado outbreak	Great Plains, Ohio Valley
2013	Accident – explosion	15		West Fertilizer Company explosion	West, Texas	More than 160 people were injured. Several years later, investigators concluded that the fire that preceded the explosion had been deliberately set.
2020	Tropical cyclone	15		Hurricane Isaias	East Coast of the United States, Puerto Rico

See also

• List of disasters in Antarctica by death toll
• List of disasters in Australia by death toll
• List of disasters in Canada by death toll
• List of disasters in Croatia by death toll
• List of disasters in Great Britain and Ireland by death toll
• List of disasters in New Zealand by death toll
• List of disasters in Poland by death toll