List of estrogens

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Estradiol, the prototypical estrogen.
Steroid ring system.

This is a list of steroidal estrogens or derivatives of estradiol, estrone, and estriol. Most esters of these estrogens are not included in this list; for esters, see here instead.

Estradiol derivatives[edit]

Compound Chemical name Structure Marketed
Estradiol (E2) Estra-1,3,5(10)-triene-3,17β-diol Estradiol.svg
2-Hydroxyestradiol 2-Hydroxyestradiol 2-Hydroxyestradiol.svg
4-Hydroxyestradiol 4-Hydroxyestradiol 4-Hydroxyestradiol.svg
4-Methoxyestradiol 4-Methoxyestradiol 4-Methoxyestradiol.svg
8β-VE2 8β-Vinylestradiol 8-vinylestradiol structure.png
16α-IE2 16α-Iodoestradiol 16iodoestradiol structure.png
16α-LE2 Estradiol 21,16α-lactone? 16aLE2 structure.png
Cloxestradiol Estradiol 17β-chloral hemiacetal ether Cloxestradiol.svg
Cloxestradiol acetate Estradiol 17β-chloral hemiacetal ether O,O-diacetate Cloxestradiol acetate.svg
Estradiol sulfate Estradiol 3-sulfate Estradiol sulfate.svg
Estrapronicate Estradiol 3-propionate 17β-nicotinate Estrapronicate.svg
Orestrate Estradiol 3-propionate 17β-(1-cyclohexenyl) ether Orestrate.svg
Polyestradiol phosphate Estradiol 17β-phosphate polymer Polyestradiol phosphate skeletal.svg
Promestriene Estradiol 3-propyl 17β-methyl diether Promestriene skeletal.svg

17α-Substituted estradiol derivatives[edit]

Compound Chemical name Structure Marketed
Cyclodiol 14α,17α-Ethanoestradiol
Estrazinol 8-Aza-17α-ethynylestradiol 3-methyl ether Estrazinol.svg
Estrofurate 17α-(3-Furyl)-δ7-estradiol 3-acetate Estrofurate.svg
Etamestrol (eptamestrol) 1-Hydroxy-7α-methyl-17α-ethynylestradiol 1,3-dibenzoate Etamestrol.svg
Ethinylestradiol (EE) 17α-Ethynylestradiol Ethinylestradiol.svg
Ethinylestradiol sulfonate (EES) 17α-Ethynylestradiol 3-isopropylsulfonate Ethinylestradiol sulfonate.svg
Ethylestradiol 17α-Ethylestradiol 17-Ethylestradiol.svg
Mestranol (EE3ME) 17α-Ethynylestradiol 3-methyl ether Mestranol.svg
Methylestradiol 17α-Methylestradiol Methylestradiol.svg
Moxestrol 11β-Methoxy-17α-ethynylestradiol Moxestrol structure.svg
Quinestrol 17α-Ethynylestradiol 3-cyclopentyl ether Quinestrol.png
RU-16117 11α-Methoxy-17α-ethynylestradiol RU-16117.svg

Nitrogen mustard-coupled alkylating antineoplastic estradiol derivatives[edit]

Compound Chemical name Structure Marketed
Alestramustine Estradiol 3-(bis(2-chloroethyl)carbamate) 17β-(2β-aminopropanoate) Alestramustine.svg
Atrimustine Estradiol 3-benzoate 17β-(4-(4-(bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy)acetate Atrimustine.svg
Estramustine Estradiol 3-(bis(2-chloroethyl)carbamate) Estramustine.svg
Estramustine phosphate Estradiol 3-(bis(2-chloroethyl)carbamate) 17β-phosphate Estramustine phosphate.svg

17β-Aminoestrogens[edit]

Compound Chemical name Structure Marketed
Aminoestradiol 17β-Aminoestradiol 17β-Aminoestradiol.svg
Butolame 17β-((4-Hydroxybutyl)amino)estradiol Butolame.svg
Hexolame 17β-((6-Hydroxyhexyl)amino)estradiol Hexolame.svg
Pentolame 17β-((5-Hydroxypentyl)amino)estradiol Pentolame.svg
Prodiame 17β-((3-Aminopropyl)amino)estradiol Prodiame.svg
Prolame 17β-((3-Hydroxypropyl)amino)estradiol Prolame.svg

Estrone derivatives[edit]

Compound Chemical name Structure Marketed
Estrone (E1) Estra-1,3,5(10)-triene-3-ol-17-one Estron.svg
2-Hydroxyestrone 2-Hydroxyestrone 2-Hydroxyestrone.svg
4-Hydroxyestrone 4-Hydroxyestrone 4-Hydroxyestrone.svg
4-Methoxyestrone 4-Methoxyestrone 4-Methoxyestrone.svg
16α-Hydroxyestrone 16α-Hydroxyestrone 16α-Hydroxyestrone.svg
Almestrone 7α-Methylestrone Almestrone.svg
Clomestrone 16α-Chloroestrone 3-methyl ether Clomestrone.svg
Estrone sulfate Estrone 3-sulfate Estrone sulfate.svg
Estropipate Estrone 3-sulfate piperazine salt Estropipate.png
Hydroxyestrone diacetate 16α-Hydroxyestrone 3,16α-diacetate Hydroxyestrone diacetate.svg

Nitrogen mustard-coupled alkylating antineoplastic estrone derivatives[edit]

Compound Chemical name Structure Marketed
Estromustine Estrone 3-(bis(2-chloroethyl)carbamate) Estromustine2DACS.svg

Estriol derivatives[edit]

Compound Chemical name Structure Marketed
Estriol (E3) 16α-Hydroxyestradiol Estriol.svg
Estetrol (E4) 15α-Hydroxyestriol Estetrol.svg
Quinestradol Estriol 3-cyclopentyl ether Quinestradiol structure.png

17α-Substituted estriol derivatives[edit]

Compound Chemical name Structure Marketed
Cyclotriol 14α,17α-Ethanoestriol
Ethinylestriol 17α-Ethynylestriol Ethinylestriol.svg
Nilestriol 17α-Ethynylestriol 3-cyclopentyl ether Nilestriol.svg

Other estrogen derivatives[edit]

Epimers[edit]

Compound Chemical name Structure Marketed
17α-Estradiol (alfatradiol) 17α-Estradiol Alfatradiol skeletal.svg
16β-Epiestriol (epiestriol) 16β-Hydroxy-17β-estradiol Epiestriol.svg
17α-Epiestriol 16α-Hydroxy-17α-estradiol 17α-Epiestriol.svg
16β,17α-Epiestriol 16β-Hydroxy-17α-estradiol 16β,17α-Epiestriol.svg
Epimestrol 17α-Epiestriol 3-methyl ether Epimestrol.png
Mytatrienediol 16α-Methyl-16β-epiestriol 3-methyl ether Mytatrienediol.svg

Equine estrogens[edit]

Compound Chemical name Structure Marketed
Equilin Δ7-Estrone Equilin.svg
Equilenin Δ6,8-Estrone Equilenin.svg
17α-Dihydroequilin Δ7-17α-Estradiol 17α Dihydroequilin.svg
17β-Dihydroequilin Δ7-17β-Estradiol 17β-Dihydroequilin.svg
17α-Dihydroequilenin Δ6,8-17α-Estradiol 17α-Dihydroequilenin.svg
17β-Dihydroequilenin Δ6,8-17β-Estradiol 17β-Dihydroequilenin.svg
8,9-Dehydroestrone Δ8-Estrone 8,9-Dehydroestrone.svg
8,9-Dehydroestradiol Δ8-17β-Estradiol 8,9-Dehydroestradiol.svg
Hippulin Δ8-14-Isoestrone Hippulin.svg

See also[edit]

Notes[edit]

? = Chemical names that are unverified.

References[edit]