List of fiction set in Pittsburgh
- Afterimage by Kathleen George
- An American Childhood by Annie Dillard
- American Rust by Philipp Meyer
- Another Kind of Monday by William Coles
- The Autobiography of My Body by David Guy
- "Belief Is Its Own Kind of Truth, Maybe" by Lori Jakiela
- Blood on the Forge by William Attaway
- The Book of Jonas by Stephen Dau
- Burning Valley by Philip Bonosky
- Captains and Kings by Taylor Caldwell
- Catapult Soul by Brian Celio
- Christine by Stephen King
- Coal Bones
- Disquiet Heart by Randall Silvis
- Duffy's Rocks by Edward Fenton
- Fallen by Kathleen George
- Ghosts of San Francisco- Tales of Eclipse Vol.1(novel) by Mord McGhee
- "Ghosts of the Golden Triangle- Tales of Eclipse Vol.2(novel)" by Mord McGhee
- Greenhorn on the Frontier by Ann Finlayson
- The Homewood Books by John Edgar Wideman
- Iron City by Lloyd L. Brown
- The Last Chicken in America by Ellen Litman
- The Leap Year Boy by Marc Simon (2013)
- Lethal Legacy by Gerald Myers
- A Little Girl in Old Pittsburg
- Looking For The General by Warren Miller
- The Man Who Liked Slow Tomatoes by K.C. Constantine
- Me and Earl and the Dying Girl by Jesse Andrews
- The Memory Keeper's Daughter
- Miss New York Has Everything by Lori Jakiela
- A Model World and Other Stories by Michael Chabon
- Monongahela Dusk by John Hoerr
- The Mysteries of Pittsburgh by Michael Chabon
- The Odds by Kathleen George
- Old Flames and Heroes (novel)' by Mord McGhee
- Out of This Furnace by Thomas Bell
- The Perks of Being a Wallflower by Stephen Chbosky
- Pittsburgh Stories by Clarke Blaise (2001)
- Riot by William Trautmann
- Seducing Mr. Darcy by Gwyn Cready (2008)
- Sent for You Yesterday by John Edgar Wideman
- Settling Accounts: Drive to the East
- Simple by Kathleen George
- Steel Ashes
- The Stolen Child
- Taken by Kathleen George
- The Tempering by Gloria Skurzynski
- Three Golden Rivers by Olive Price
- Tumbling Through Time by Gwyn Cready (2007)
- The Two Georges
- U.S.A. by John dos Passos
- Ukiah Oregon series
- Watch Your Mouth by Daniel Handler
- Wonder Boys by Michael Chabon
- The Pittsburgh Cycle - In 2005, August Wilson completed a ten-play cycle, nine of which are set in Pittsburgh, chronicling the African-American experience in the 20th century. These are:
- 1900s - Gem of the Ocean (2003)
- 1910s - Joe Turner's Come and Gone (1984)
- 1920s - Ma Rainey's Black Bottom (1982) - set in Chicago
- 1930s - The Piano Lesson (1986) - Pulitzer Prize
- 1940s - Seven Guitars (1995)
- 1950s - Fences (1985) - Pulitzer Prize
- 1960s - Two Trains Running (1990)
- 1970s - Jitney (1982)
- 1980s - King Hedley II (2001)
- 1990s - Radio Golf (2005)
- "America", written by Paul Simon and performed by Simon & Garfunkel, includes the line "Kathy", I said, / As we boarded a Greyhound in Pittsburgh, / Michigan seems like a dream to me now."
- "Duquesne Whistle," which appears on the Bob Dylan album Tempest, was co-written by Dylan and Robert Hunter. The song describes a train ride through Pittsburgh. NPR's Ann Powers speculates that this may be the same train described in Dylan's "Lo and Behold".
- "A Good Man Is Hard to Find" by Bruce Springsteen describes "It's cloudy out in Pittsburgh / It's raining in Saigon / Snow's falling across the Michigan line."
- "I'm Not Dead (I'm in Pittsburgh)", which appears on the Frank Black album Fast Man Raider Man, was co-written by Black and Pittsburgher Reid Paley. It draws upon Pittsburgh's historical connection with the zombie genre.
- "I finally found a place to call my own / a place where all good sinners can get stoned / I'll keep my holy vision, you keep your stupid pride / You said I couldn't make it on my own / But I'm not dead (I'm in Pittsburgh) / And now I can't get out of town / But I'm not dead (I'm in Pittsburgh) / They've got me all strung, come cut me down."
- "Life During Wartime," which appears on the Talking Heads' Fear of Music and Stop Making Sense, asks the listener in a post-apocalyptic landscape, "Heard about Houston? Heard about Detroit? Heard about Pittsburgh, PA?" Long-time Talking Heads drummer Chris Frantz grew up in Pittsburgh.
- "Lo and Behold," which appears on the The Basement Tapes by Bob Dylan and the Band, tells the story of the narrator recounting a train ride with "I come into Pittsburgh / At six-thirty flat / I found myself a vacant seat / An' I put down my hat."
- "Sweet Little Sixteen", by Chuck Berry, rhymes "Pittsburgh, P.A." with "Frisco Bay."
- "Six Days on the Road", written by Earl Green and Carl Montgomery, describes a trucker who says "Well, I pulled out of Pittsburgh", in describing life on the road.
- Pittsburgher Wiz Khalifa often mentions the city in his music.
- Norman, Tony (June 27, 2006). "Pittsburgh never sounded so right". Pittsburgh Post-Gazette. Retrieved January 3, 2015.
- Powers, Ann (August 27, 2012). "Song Premiere: Bob Dylan, 'Duquesne Whistle'". NPR. Retrieved January 3, 2015.