List of investigational antidepressants

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This is a list of investigational antidepressants, or antidepressants that are currently under development for clinical use in the treatment of mood disorders but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. All drugs listed are specifically under development for major depressive disorder (MDD) or treatment-resistant depression (TRD) unless noted otherwise.

Glutamatergics[edit]

NMDA receptor modulators[edit]

Others[edit]

Monoaminergics[edit]

Monoamine reuptake inhibitors[edit]

Monoamine reuptake inhibitors and receptor modulators[edit]

Monoamine receptor modulators[edit]

Atypical antipsychotics[edit]

  • Lumateperone (ITI-007) – AA – specifically under development for the treatment of depressive episodes in bipolar disorder[23]
  • RP-5063 (RP-5000) – AA – specifically under development for the treatment of MDD and depressive episodes in bipolar disorder[24]

Others[edit]

Neurosteroids[edit]

GABAA receptor positive modulators[edit]

  • Ganaxolone (CCD-1042) – GABAA receptor positive allosteric modulator – specifically under development for the treatment of postpartum depression[26]
  • Zuranolone (SAGE-217) – GABAA receptor positive allosteric modulator – specifically under development for the treatment of both MDD and postpartum depression[27]

Others[edit]

Opioidergics[edit]

κ-Opioid receptor antagonists[edit]

Others[edit]

Others[edit]

Mixed[edit]

Combinations[edit]

Not under development[edit]

The following drugs are currently of major investigational interest as potential antidepressants but are not formally under clinical development for approval at this time:

See also[edit]

References[edit]

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Further reading[edit]

External links[edit]