List of largest selling pharmaceutical products
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Current largest selling pharmaceuticals of global market
[edit]The top ten best-selling pharmaceuticals of 2025. Sales in billion USD.[1]
| Rank | Drug | Main indication | Trade name | Sales |
|---|---|---|---|---|
| 1 | pembrolizumab | oncology | Keytruda | 31.6 |
| 2 | tirzepatide | diabetes, obesity | Mounjaro | 23.0 |
| 3 | semaglutide | diabetes, obesity | Ozempic | 19.2 |
| 4 | dupilumab | atopic dermatitis | Dupixent | 17.8 |
| 5 | risankizumab | plaque psoriasis | Skyrizi | 17.6 |
| 6 | apixaban | anticoagulant | Eliquis | 14.7 |
| 7 | daratumumab | multiple myeloma | Darzalex | 14.4 |
| 8 | Bictegravir/emtricitabine/ | HIV/AIDS | Biktarvy | 14.3 |
| 9 | tirzepatide | diabetes, obesity | Zepbound | 13.5 |
| 10 | semaglutide | diabetes, obesity | Wegovy | 12.0 |
Historical largest selling pharmaceuticals
[edit]2020-2024
[edit]2024
[edit]The top ten best-selling pharmaceuticals of 2024. Sales in billion USD.[2]
| Rank | Drug | Main indication | Trade name | Sales |
|---|---|---|---|---|
| 1 | pembrolizumab | oncology | Keytruda | 29.5 |
| 2 | semaglutide | diabetes, obesity | Ozempic | 17.5 |
| 3 | dupilumab | atopic dermatitis | Dupixent | 14.1 |
| 4 | Bictegravir/emtricitabine/ | HIV/AIDS | Biktarvy | 13.4 |
| 5 | apixaban | anticoagulant | Eliquis | 13.3 |
| 6 | risankizumab | plaque psoriasis | Skyrizi | 11.7 |
| 7 | daratumumab | multiple myeloma | Darzalex | 11.7 |
| 8 | tirzepatide | diabetes, obesity | Mounjaro | 11.5 |
| 9 | ustekinumab | psoriasis | Stelara | 10.4 |
| 10 | elexacaftor/tezacaftor/ivacaftor | cystic fibrosis | Trikafta | 10.2 |
2023
[edit]The top ten best-selling pharmaceuticals of 2023. Sales in billion USD.[3]
| Rank | Drug | Main indication | Trade name | Sales |
|---|---|---|---|---|
| 1 | pembrolizumab | oncology | Keytruda | 25.0 |
| 2 | adalimumab | rheumatoid arthritis | Humira | 14.4 |
| 3 | semaglutide | diabetes, obesity | Ozempic | 13.9 |
| 4 | apixaban | anticoagulant | Eliquis | 12.2 |
| 5 | Bictegravir/emtricitabine/ | HIV/AIDS | Biktarvy | 11.9 |
| 6 | dupilumab | atopic dermatitis | Dupixent | 11.6 |
| 7 | Pfizer–BioNTech COVID-19 vaccine | COVID-19 vaccination | Comirnaty | 11.2 |
| 8 | ustekinumab | psoriasis | Stelara | 10.9 |
| 9 | daratumumab | multiple myeloma | Darzalex | 9.7 |
| 10 | nivolumab | oncology | Opdivo | 9.0 |
2022
[edit]The top ten best-selling pharmaceuticals of 2022. Sales in billion USD.[4]
| Rank | Drug | Main indication | Trade name | Sales |
|---|---|---|---|---|
| 1 | Pfizer–BioNTech COVID-19 vaccine | COVID-19 vaccination | Comirnaty | 40.8 |
| 2 | Moderna COVID-19 vaccine | COVID-19 vaccination | Spikevax | 21.8 |
| 3 | adalimumab | rheumatoid arthritis | Humira | 21.6 |
| 4 | pembrolizumab | oncology | Keytruda | 21.0 |
| 5 | nirmatrelvir/ritonavir | COVID-19 | Paxlovid | 19.0 |
| 6 | apixaban | anticoagulant | Eliquis | 11.8 |
| 7 | Bictegravir/emtricitabine/ | HIV/AIDS | Biktarvy | 10.4 |
| 8 | aflibercept | macular degeneration, | Eylea | 10.3 |
| 9 | ustekinumab | psoriasis | Stelara | 10.1 |
| 10 | lenalidomide | oncology | Revlimid | 10.0 |
2021
[edit]The top ten best-selling pharmaceuticals of 2021. Sales in billion USD.[5]
| Rank | Drug | Main indication | Trade name | Sales |
|---|---|---|---|---|
| 1 | Pfizer–BioNTech COVID-19 vaccine | COVID-19 vaccination | Comirnaty | 36.9 |
| 2 | adalimumab | rheumatoid arthritis | Humira | 20.7 |
| 3 | Moderna COVID-19 vaccine | COVID-19 vaccination | Spikevax | 17.7 |
| 4 | pembrolizumab | oncology | Keytruda | 17.2 |
| 5 | lenalidomide | oncology | Revlimid | 12.8 |
| 6 | apixaban | anticoagulant | Eliquis | 10.8 |
| 7 | ustekinumab | psoriasis | Stelara | 9.1 |
| 8 | Bictegravir/emtricitabine/ | HIV/AIDS | Biktarvy | 8.6 |
| 9 | nivolumab | oncology | Opvido | 7.6 |
| 10 | dulaglutide | diabetes | Trulicity | 6.5 |
2020
[edit]The top ten best-selling pharmaceuticals of 2020. Sales in billion USD.[6]
| Rank | Drug | Main indication | Trade name | Sales |
|---|---|---|---|---|
| 1 | adalimumab | rheumatoid arthritis | Humira | 20.4 |
| 2 | pembrolizumab | oncology | Keytruda | 14.4 |
| 3 | lenalidomide | oncology | Revlimid | 12.2 |
| 4 | apixaban | anticoagulant | Eliquis | 9.2 |
| 5 | aflibercept | macular degeneration, | Eylea | 8.4 |
| 6 | ustekinumab | psoriasis | Stelara | 7.9 |
| 7 | nivolumab | oncology | Opvido | 7.9 |
| 8 | ibrutinib | oncology | Imbruvica | 7.6 |
| 9 | Bictegravir/emtricitabine/ | HIV/AIDS | Biktarvy | 7.3 |
| 10 | rivaroxaban | anticoagulant | Xarelto | 6.9 |
2012-2019
[edit]Top five best-selling pharmaceuticals 2012-2019.
2000-2011
[edit]Cumulative top ten best-selling pharmaceuticals between 2000 and 2011. Sales in billion USD[16]
| Rank | Drug | Main indication | Trade name | Sales |
|---|---|---|---|---|
| 1 | atorvastatin | cholesterol | Lipitor | 121.4 |
| 2 | clopidogrel | heart disease | Plavix | 74.6 |
| 3 | fluticasone/salmeterol | asthma | Advair | 58.8 |
| 4 | olanzapine | schizophrenia, | Zyprexa | 50.4 |
| 5 | etanercept | rheumatoid arthritis | Enbrel | 45.2 |
| 6 | esomeprazole | gastrointestinal disorders | Nexium | 44.3 |
| 7 | montelukast | asthma | Singulair | 38.5 |
| 7 | quetiapine fumarate | schizophrenia, | Seroquel | 36.7 |
| 9 | enoxaparin | anticoagulant | Lovenox | 33.1 |
| 10 | adalimumab | rheumatoid arthritis | Humira | 32.0 |
See also
[edit]References
[edit]- ^ Verdin, Paul (2026-03-06). "Top companies and drugs by sales in 2025". Nature Reviews Drug Discovery. 25 (4): 258–258. doi:10.1038/d41573-026-00041-5. ISSN 1474-1784.
- ^ Verdin, Paul (2025-03-12). "Top companies and drugs by sales in 2024". Nature Reviews Drug Discovery. 24 (4): 240–240. doi:10.1038/d41573-025-00049-3. ISSN 1474-1784.
- ^ Verdin, Paul (2024-03-08). "Top companies and drugs by sales in 2023". Nature Reviews Drug Discovery. 23 (4): 240–240. doi:10.1038/d41573-024-00041-3.
- ^ Urquhart, Lisa (2023-03-07). "Top companies and drugs by sales in 2022". Nature Reviews Drug Discovery. 22 (4): 260–260. doi:10.1038/d41573-023-00039-3.
- ^ Urquhart, Lisa (2022-03-11). "Top companies and drugs by sales in 2021". Nature Reviews Drug Discovery. 21 (4): 251–251. doi:10.1038/d41573-022-00047-9.
- ^ Urquhart, Lisa (2021-03-16). "Top companies and drugs by sales in 2020". Nature Reviews Drug Discovery. 20 (4): 253–253. doi:10.1038/d41573-021-00050-6.
- ^ Urquhart, Lisa (2020-03-13). "Top companies and drugs by sales in 2019". Nature Reviews Drug Discovery. 19 (4): 228–228. doi:10.1038/d41573-020-00047-7.
- ^ Urquhart, Lisa (2019-03-12). "Top drugs and companies by sales in 2018". Nature Reviews Drug Discovery. 18 (4): 245–245. doi:10.1038/d41573-019-00049-0.
- ^ Urquhart, Lisa (2018-04-01). "Top drugs and companies by sales in 2017". Nature Reviews Drug Discovery. 17 (4): 232–232. doi:10.1038/nrd.2018.42. ISSN 1474-1784.
- ^ Philippidis, Alex (2017-03-06). "The Top 15 Best-Selling Drugs of 2016". GEN - Genetic Engineering and Biotechnology News. Retrieved 2026-05-07.
- ^ "The Top 15 Best-Selling Drugs of 2016". 6 March 2017.
- ^ "Top drugs by sales revenue in 2015: Who sold the biggest blockbuster drugs?". March 10, 2016. Retrieved October 19, 2016.
- ^ Philippidis, Alex (2015-02-23). "The Top 25 Best-Selling Drugs of 2014". GEN - Genetic Engineering and Biotechnology News. Retrieved 2026-05-07.
- ^ Drugs.com U.S. Pharmaceutical Sales - Q4 2013, updated Feb. 2014
- ^ Philippidis, Alex (2013-03-05). "Top 20 Best-Selling Drugs of 2012". GEN - Genetic Engineering and Biotechnology News. Retrieved 2026-05-07.
- ^ Philippidis, Alex (2012-11-06). "Top 10 Best-Selling Drugs of the 21st Century". GEN - Genetic Engineering and Biotechnology News. Retrieved 2026-05-07.