List of second-generation Major League Baseball players
The following is a list of father-and-son combinations who have played or managed in Major League Baseball (MLB).
Ken Griffey Sr. and Ken Griffey Jr. became the first father-and-son combination to play in Major League Baseball at the same time, in 1989 when Ken Jr. was called up by the Seattle Mariners while Ken Sr. was playing with the Cincinnati Reds. They became Mariner teammates in 1990. In Ken Sr.'s first game as a Mariner, on August 31, 1990, the pair hit back-to-back singles in the first inning and both scored. On September 14, in the top of the first off California Angels pitcher Kirk McCaskill, the pair hit back-to-back home runs, becoming the first and only father-son duo to ever accomplish such a feat. The duo played a total of 51 games together before Griffey, Sr., retired in June 1991.
In 1992, Bret Boone became the first third-generation MLB player in baseball history.
Altogether, there have been five three-generation MLB-player families:
- The Bells (Gus, Buddy, David and Mike)
- The Boones (Ray, Bob, Bret and Aaron)
- The Colemans (Joe, Joe Jr., and Casey)
- The Hairstons (Sammy, Jerry, Johnny, Jerry Jr. and Scott)
- The Schofield/Werths (Ducky Schofield, Dick Schofield and Jayson Werth). Werth is the grandson of Ducky Schofield and nephew of Dick Schofield, and also the stepson of Dennis Werth.
As of 2017, the Boone family is the only one to have produced four generations of players: Ray, Bob, Bob's sons Aaron and Bret, and Bret's son Jake, who was selected by the Washington Nationals in the 2017 draft. 
|Italic||Managed his son(s)|
|†||Elected to the Baseball Hall of Fame|
|*||Player is active|
List of players
Other second-generation MLB personnel
Parent played top-level professional baseball
The following families had a parent play top-level professional baseball in a league other than Major League Baseball, and a son who played in Major League Baseball:
|Luis Aparicio, Sr.||SS||Venezuelan Professional Baseball League||Luis Aparicio†||SS|
|Lyman Bostock, Sr.||1B||Negro Leagues||Lyman Bostock||OF|
|Helen Callaghan||CF||All-American Girls Professional Baseball League||Casey Candaele||UTL|
|Pedro Cepeda||SS/1B||Puerto Rico Baseball League||Orlando Cepeda†||1B|
|Martinez Jackson||2B||Negro Leagues||Reggie Jackson†||RF|
|Kazuhiro Kuroda||CF||Nippon Professional Baseball||Hiroki Kuroda||P|
|Leon Lee||1B||Nippon Professional Baseball||Derrek Lee||1B|
|Luis Tiant, Sr.||P||Negro Leagues||Luis Tiant||P|
|*||Umpire is active|
|Shag Crawford||NL||Jerry Crawford2||NL/MLB|
|Lou DiMuro||AL||Mike DiMuro||AL/MLB, CL (Japan)|
|Tom Gorman||NL||Brian Gorman||NL/MLB|
|Ed Runge||AL||Paul Runge||NL|
|Paul Runge||NL||Brian Runge||NL/MLB|
|Harry Wendelstedt||NL||Hunter Wendelstedt||NL/MLB|
^1 The National and American Leagues consolidated umpiring crews beginning in the 2000 season; umpires who worked after the consolidation are denoted with "MLB".
^2 Joe Crawford, another son of Shag Crawford and brother of Jerry Crawford, is an official in the National Basketball Association.
- "August 31, 1990 Kansas City Royals at Seattle Mariners Play by Play and Box Score". Baseball-Reference.com. August 31, 1990. Retrieved February 16, 2011.
- "September 14, 1990 Seattle Mariners at California Angels Play by Play and Box Score". Baseball-Reference.com. September 14, 1990. Retrieved February 16, 2011.
- "Nationals draft Dusty's son Darren Baker in 27th round". Retrieved June 14, 2017.