List of side effects of trimethoprim/sulfamethoxazole

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Adverse effects by incidence of trimethoprim/sulfamethoxazole [1][2][3][4][5][6][7]

Common (>1% frequency)[edit]

  • Fever
  • Nausea
  • Vomiting
  • Diarrhea
  • Weight loss
  • Rash
  • Muscle aches
  • Joint pain
  • Itch
  • Sore mouth
  • Hyperkalaemia (high blood potassium)
  • Thrombocytopenia (low number of platelets in the blood)

Infrequently (0.1–1.0% frequency)[edit]

  • Headache
  • Jaundice
  • Elevated liver transaminases
  • Peripheral neuritis
  • Drowsiness
  • Constipation
  • Photosensitivity (light sensitivity)
  • Blood dyscrasias (e.g. neutropaenia)

Rare (<0.1% frequency)[edit]

Unknown frequency[edit]

  • Hallucinations
  • Cough
  • Glossitis
  • Stomatitis
  • Fatigue
  • Insomnia
  • Impaired kidney function
  • Pulmonary infiltration[f]
  • Shortness of breath

Notes[edit]

  1. ^ Breakdown of red blood cells. This side effect most often occurs in people with glucose-6-phosphate dehydrogenase deficiency
  2. ^ A potentially fatal skin reaction that causes the skin to slough off
  3. ^ Basically a worse form of Stevens-Johnson syndrome
  4. ^ Incoordination; most often after IV use in HIV patients
  5. ^ Swelling of the membranes surrounding the brain and spinal cord without any obvious infectious cause
  6. ^ Sign of hypersensitivity

References[edit]

  1. ^ "Bactrim, Bactrim DS (trimethoprim/sulfamethoxazole) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 13 January 2014. 
  2. ^ "BACTRIM®" (PDF). TGA eBusiness Services. Roche Products Pty Limited. 18 September 2012. Retrieved 13 January 2014. 
  3. ^ "BACTRIM DS (sulfamethoxazole and trimethoprim) tablet BACTRIM (sulfamethoxazole and trimethoprim) tablet [AR Scientific, Inc.]". DailyMed. AR Scientific, Inc. June 2013. Retrieved 13 January 2014. 
  4. ^ "Co-Trimoxazole Tablets 80/400mg - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Actavis UK Ltd. 17 October 2012. Retrieved 13 January 2014. 
  5. ^ Joint Formulary Committee (2013). British National Formulary (BNF) (65 ed.). London, UK: Pharmaceutical Press. ISBN 978-0-85711-084-8. 
  6. ^ Rossi, S, ed. (2013). Australian Medicines Handbook (2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust. ISBN 978-0-9805790-9-3. 
  7. ^ "e-Therapeutics+e-CPS". Sulfamethoxazole-Trimethoprim CPhA Monograph. Retrieved 28 March 2015.