List of target antigens in pemphigus

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Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigus.

Target antigens for the different pemphigus variants
Pemphigus variant Antibody isotype Antigen Molecular weight (KDa)
Mucosal pemphigus vulgaris IgG Desmoglein 3 130
Mucocutaneous pemphigus vulgaris IgG Desmoglein 3
Desmoglein 1
130
160
Pemphigus foliaceus IgG Desmoglein 1 160
Paraneoplastic pemphigus IgG Desmoglein 3
Desmoglein 1
BPAG1[nb 1]
Plectin
Desmoplakin I[nb 2]
Desmoplakin II
Envoplakin
Periplakin
Alpha-2-macroglobulin-like-1
130
160
230
500
250
210
210
190
170
Drug-induced pemphigus IgG Desmoglein 3
Desmoglein 1
130
160
Subcorneal pustular dermatosis type of IgA pemphigus IgA1 Desmocollin 1 110/100
Intraepidermal neutrophilic type of IgA pemphigus IgA1 Unknown
Pemphigus erythematosus (Senear–Usher syndrome)[nb 3] IgG Desmoglein 1 160
Fogo selvagem IgG Desmoglein 1 160
Pemphigus vegetans IgG Desmoglein 3 130
Pemphigus vegetans of Hallopeau[nb 4] IgG Desmoglein 3 130
Pemphigus vegetans of Neumann[nb 4] IgG Desmoglein 3 130
Pemphigus herpetiformis IgG Desmoglein 3
Desmoglein 1
130
160

Footnotes[edit]

  1. ^ Notably not BPAG2
  2. ^ Desmoplakin I and II autoantibodies have also been reported in Stevens–Johnson syndrome
  3. ^ Parentheticals are used to indicate other names by which a condition is known. If there are multiple alternative names for a condition, they are separated by commas within the parenthetical.
  4. ^ a b Pemphigus vegetans of Hallopeau represents a mild form of pemphigus vegetans. Pemphigus vegetans of Neumann represents a severe form of pemphigus vegetans.

See also[edit]

References[edit]

  • Bolognia, Jean L.; et al. (2007). Dermatology. St. Louis: Mosby. ISBN 1-4160-2999-0. 
  • James, William D.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.