Calzado was born in Manila. While a student at the University of the East, he joined the university folk dance troupe under the direction of Maggie Shea. He also danced for television with Alice Reyes' group and with Amelia Apolinario's group. He danced with the Bayanihan Philippine Dance Company and the Ballet Folkoric Filipino from 1961 to 1969. As a choreographer, he became dance director of the ABS-CBN Dance Company. Lito Calzado and his dancers which is also known as the "Body Machine" is what he has formed for popular shows.
Calzado married Maria Antonia Ussher, a woman of Irish–Spanish–Filipina descent. He is the father of Iza Calzado. His son Dash Calzado is a member of Legit Misfitz, a Filipino rap group. He later ran an entertainment and management center, and trains dance groups for clubs and other venues in Japan.