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Clinical data
ATC code
  • none
CAS Number
PubChem CID
Chemical and physical data
Formula C16H19NO
Molar mass 241.327 g/mol
3D model (Jmol)

Litoxetine (SL 81-0385) is an antidepressant which was under clinical development for the treatment of depression in the early 1990s.[1] It acts as a serotonin reuptake inhibitor and 5-HT3 receptor antagonist. It has prominent antiemetic properties, and unlike the selective serotonin reuptake inhibitors (SSRIs), it was shown to have a negligible incidence of nausea and emesis.[2] Development of litoxetine for medicinal use was apparently halted in the late 1990s.


  1. ^ Fairweather DB, Patat A, Rosenzweig P, Curson VH, Dunmore C, Dubruc C, Hindmarch I (August 1995). "The psychomotor and cognitive effects of litoxetine in young and middle aged volunteers". British Journal of Clinical Pharmacology. 40 (2): 119–25. doi:10.1111/j.1365-2125.1995.tb05767.x. PMC 1365170Freely accessible. PMID 8562293. 
  2. ^ Angel I, Schoemaker H, Prouteau M, Garreau M, Langer SZ (March 1993). "Litoxetine: a selective 5-HT uptake inhibitor with concomitant 5-HT3 receptor antagonist and antiemetic properties". European Journal of Pharmacology. 232 (2-3): 139–45. doi:10.1016/0014-2999(93)90767-C. PMID 8385615.