"Little Miss Can't Be Wrong" is a song by American rock group Spin Doctors. It was released in October 1992 as the lead single from their 1991 debut album Pocket Full of Kryptonite. Live versions of "What Time Is It?" and "Freeway of the Plains" (mistakenly titled "Freeway of Plains" on the single) were included as its B-side. The single reached number 17 on the US Billboard Hot 100 and number two on the BillboardAlbum Rock Tracks chart. It also reached number five in New Zealand, its highest national chart position anywhere, and ended 1993 as the country's 41st best-selling single.
During a 2011 performance for National Public Radio's World Cafe, lead singer Chris Barron commented that despite popular belief that the song was about an ex-girlfriend, it was actually written about his former stepmother. On August 10, 2019, Barron tweeted confirmation of this, adding that his stepmother told him he'd be a janitor and live in the basement of a school playing guitar for the rats.