Paul McCartney performed the song live alongside David Gilmour for a 1999 PETA fundraiser concert.
The Ventures recorded at least two versions of this song, the first released in 1961 on their album The Ventures (subsequently mistitled on later CDs as Lonesome Road) and the second, new recording on their 1975 cassette-only album Hollywood Metal Dinamic Sound 3000.
The song appears on the soundtrack to the film Pulp Fiction. The song is played over characters Mia and Vincent begin their conversation in the restaurant.
The song was used on the NBC television series Heroes in chapter 14 of the fourth season, in the episode "Close to You", which aired January 11, 2010. Sometime-evil carny leader and lonesome heart Sam Sullivan (actor Robert Knepper) chooses the song on a diner jukebox and orders a milkshake, reminiscent of the scene in Pulp Fiction. A closeup of the milkshake is shown as Sam invokes an "earthquake", which then drowns out the music. The song runs from 38:35-39:52 in the episode.