Longitudinal callosal fascicle

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Longitudinal callosal fascicles (or Probst bundles) are abnormal collections of brain cells characteristic of patients with agenesis of the corpus callosum. Failure of the callosally-projecting neurons (mostly layer 2/3 pyramidal neurons) to extend axons across the midline and therefore form the corpus callosum[clarification needed] results in anomalous collection of these axonal projections in both hemispheres. Longitudinal callosal fascicles were originally described by Moriz Probst in 1901 by gross anatomical observation.[1] More recently, these anomalies are detected by Magnetic Resonance Imaging [2] or Diffusion Tensor Imaging.[3]


  1. ^ Probst, M. (1901), "Über den Bau des vollständig balkenlosen Großhirns", Arch Psychiatr, 34: 709–786, doi:10.1007/bf02680175 
  2. ^ Barkovich, AJ.; Norman, D. (Jul 1988), "Anomalies of the corpus callosum: correlation with further anomalies of the brain.", AJR Am J Roentgenol, 151 (1): 171–9, PMID 3259802 
  3. ^ Lee, SK.; Mori, S.; Kim, DJ.; Kim, SY.; Kim, SY.; Kim, DI. (Jan 2004). "Diffusion tensor MR imaging visualizes the altered hemispheric fiber connection in callosal dysgenesis.". AJNR Am J Neuroradiol. 25 (1): 25–8. PMID 14729523.