The original version of the song begins with a dialogue between the singer and God. The former asks for an angel and the latter says, having no angels, He'll send "a teasin' brown". The rest of the lyrics describe the singer's promiscuity and liking for women of different complexions: "One woman's Atlanta yellow, the other is Macon brown, but the Statesboro blackskin will turn your damper down". The song ends with the singer addressing a lover, saying he's leaving her and that she'll be sorry she drove him away, perhaps wishful thinking judging by the way he claims to regard women.
The alternate verses of "Ticket Agent Blues" lengthens the song, telling a story of the protagonist seeking his lover at a train station, describing her appearance to the ticket agent, and includes a warning to avoid relationships with married women, "cause their husband will grab ya, and beat ya ragged as a cedar tree". The song then ends in a similar fashion, the addressing a lover to tell her he's leaving her; however, this time the singer warns "I'ma tell you pretty mama exactly who I am, when I walk in that front door and hear that back door slam".