Lorena S. Beese

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Lorena S. Beese
Born Lorena Sue Beese
Residence Durham, North Carolina
Fields Cancer Research, DNA replication, DNA mismatch repair
Institutions Duke University School of Medicine
Alma mater
Spouse Homme Hellinga

Lorena Beese is a James B. Duke Professor of Biochemistry at Duke University. She received her PhD in Biophysics from Brandeis University and did her postdoctoral work with Dr. Thomas A. Steitz at Yale University. In 2009 Dr. Beese was elected to the National Academy of Sciences.[1] Her research interests include structural biochemistry of DNA replication and human DNA mismatch repair and its connection to carcinogenesis. She is also interested in protein prenylation enzymes as targets for structure-based discovery of anticancer therapeutics and re-purposing of such therapeutics to treat pathogenic fungi and malaria.[2]

Research Interests[edit]

  • Signal transduction
  • Structure based drug design
  • DNA replication
  • DNA mismatch repair
  • Observing enzymes in action

Selected Works[edit]


  1. ^ "Lorena Beese, Member Directory". National Academy of Sciences. Retrieved 30 March 2016. 
  2. ^ "Lorena S. Beese (Primary)". Biochemistry Lab, Duke University School of Medicine. Retrieved 30 March 2016.