Lori Ann Setton

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Lori Ann Setton
Alma materPrinceton University
Columbia University
Known formechanics
mechanobiology of the intervertebral disc
articular cartilagemechanics
drug delivery
pathomechanisms of osteoarthritis
AwardsAIMBE Fellow (2005)
BMES Fellow (2009)
Van C. Mow Medal(2007)
Scientific career
FieldsBiomechanical Engineer
InstitutionsWashington University, Duke University
Doctoral advisorVan C. Mow

Lori Ann Setton is an American biomechanical engineer noted for her research on mechanics and mechanobiology of the intervertebral disc, articular cartilage mechanics, drug delivery, and pathomechanisms of osteoarthritis. She is currently the Department Chair as well as the Lucy and Stanley Lopata Distinguished Professor of Biomedical Engineering at Washington University in St. Louis.


Setton was born in Queens, New York. She received a B.S.E. in Mechanical and Aerospace Engineering from Princeton University in 1984. Subsequently, she pursued graduate degrees under the tutelage of Professor Van C. Mow at Columbia University. She received an M.S. degree and Ph.D degree in Mechanical Engineering/Biomechanics in 1988 and 1993, respectively.

She joined the Department of Biomedical Engineering at Duke University as an assistant professor in 1995. Promotions to tenured associate professor in and professor followed in 2004 and 2007.

Her most noticeable work has documented the biological responses of cartilage and intervertebral disc to mechanical loading,[1] [2] [3] [4] [5] [6] understanding a role for collagen genetic mutations in onset of arthritis and intervertebral disc pathology,[7] [8] development of injectable hydrogels for articular cartilage repair,[9][10][11][12] and development of injectable drug delivery vehicles for fighting inflammation in musculoskeletal disease.[13][14][15][16][17] As of June 1, 2017, her work has been cited over 17500 times.[18] She has an h-index of 65.


Setton has several awards:

  • Dean's Award for Excellence in Mentoring, Duke Graduate School(2004)[22]
  • Stansell Family Distinguished Research Award (2001)[23]
  • Presidential Early Career Awards for Scientists and Engineers (PECASE) (1997) for "Leadership in education and research in understanding and restoring biomechanical functions to tissue degenerated by injury or aging, especially in the spine[24]


  1. ^ Setton, LA; Chen, J (2006). "Mechanobiology of the intervertebral disc and relevance to disc degeneration". J Bone Joint Surg Am. 88 (2): 52–57. doi:10.2106/JBJS.F.00001. PMID 16595444.(cited 154 times)
  2. ^ Setton, LA; Mow, VC; Müller, FJ; Pita, JC; Howell, DS (1994). "Mechanical properties of canine articular cartilage are significantly altered following transection of the anterior cruciate ligament". Journal Orthopedic Research. 12 (4): 451–463. doi:10.1002/jor.1100120402. PMID 8064477.(cited 168 times)
  3. ^ LeRoux, MA; Arokoski, J; Vail, TP; Guilak, F; Hyttinen, MM; Kiviranta, I; Setton, LA (2000). "Simultaneous changes in the mechanical properties, quantitative collagen organization, and proteoglycan concentration of articular cartilage following canine meniscectomy". Journal of Orthopaedic Research. 18 (3): 383–392. doi:10.1002/jor.1100180309. PMID 10937624.(cited 122 times)
  4. ^ Leroux, MA; Cheung, HS; Bau, JL; Wang, JY; Howell, DS; Setton, LA (2001). "Altered mechanics and histomorphometry of canine tibial cartilage following joint immobilization". Osteoarthritis and Cartilage. 9 (7): 633–640. doi:10.1053/joca.2001.0432. PMID 11597176.(cited 62 times)
  5. ^ Boyd, LM; Richardson, WJ; Chen, J; Kraus, VB; Tewari, A; Setton, LA (2005). "Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real-time quantitative RT-PCR". Annals of Biomedical Engineering. 33 (8): 1071–1077. CiteSeerX doi:10.1007/s10439-005-5775-y. PMID 16133915.(cited 35 times)
  6. ^ Chen, J; Yan, W; Setton, LA (2004). "Static compression induces zonal-specific changes in gene expression for extracellular matrix and cytoskeletal proteins in intervertebral disc cells in vitro". Matrix Biology. 22 (7): 573–583. doi:10.1016/j.matbio.2003.11.008. PMID 14996437.(cited 74 times)
  7. ^ Boyd, LM; Richardson, WJ; Allen, KD; Flahiff, C; Jing, L; Li, Y; Chen, J; Setton, LA (2008). "Early-onset degeneration of the intervertebral disc and vertebral end plate in mice deficient in type IX collagen". Arthritis Rheum. 58 (1): 164–171. doi:10.1002/art.23231. PMID 18163498.(cited 40 times)
  8. ^ Allen, KD; Griffin, TM; Rodriguiz, RM; Wetsel, WC; Kraus, VB; Huebner, JL; Boyd LM; Setton, LA (2009). "Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen". Arthritis Rheum. 60 (9): 2684–2693. doi:10.1002/art.24783. PMC 2760314. PMID 19714629.(cited 29 times)
  9. ^ Nettles, DL; Chilkoti, A; Setton, LA (2010). "Applications of elastin-like polypeptides in tissue engineering". Adv Drug Deliv Rev. 62 (15): 1479–1485. doi:10.1016/j.addr.2010.04.002. PMC 2935943. PMID 20385185.(cited 114 times)
  10. ^ Nettles DL; Kitaoka, K; Hanson, NA; Flahiff, CM; Mata, BA; Hsu, EW; Chilkoti, A; Setton, LA (2008). "In situ crosslinking elastin-like polypeptide gels for application to articular cartilage repair in a goat osteochondral defect model". Tissue Eng Part A. 14 (7): 1133–1140. doi:10.1089/tea.2007.0245. PMC 3312393. PMID 18433311.(cited 50times)
  11. ^ Betre, H; Ong, SR; Guilak, F; Chilkoti, A; Fermor, B; Setton, LA (2006). "Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide". Biomaterials. 27 (1): 91–99. doi:10.1016/j.biomaterials.2005.05.071. PMID 16023192.
  12. ^ Nettles, DL; Vail, TP; Morgan, MT; Grinstaff, MW; Setton, LA (2004). "Photocrosslinkable hyaluronan as a scaffold for articular cartilage repair". Ann Biomed Eng. 32 (3): 391–397. doi:10.1023/b:abme.0000017552.65260.94. PMID 15095813.
  13. ^ Allen, KD; Adams, SB Jr; Mata, BA; Shamji, MF; Gouze, E; Jing, L; Nettles, DL; Latt, LD; Setton, LA (2010). "Gait and behavior in an IL1β-mediated model of rat knee arthritis and effects of an IL1 antagonist". Journal of Orthopaedic Research. 29 (5): 694–703. doi:10.1002/jor.21309. PMC 3100769. PMID 21437948.
  14. ^ Shamji, MF; Chen, J; Friedman, AH; Richardson, WJ; Chilkoti, A; Setton, LA (2008). "Synthesis and characterization of a thermally-responsive tumor necrosis factor antagonist". J Control Release. 129 (3): 179–186. doi:10.1016/j.jconrel.2008.04.021. PMC 2637771. PMID 18547669.
  15. ^ Shamji, MF; Betre, H; Kraus, VB; Chen, J; Chilkoti, A; Pichika, R; Masuda, K; Setton LA (2007). "Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic". Arthritis Rheum. 56 (11): 3650–3661. doi:10.1002/art.22952. PMID 17968946.
  16. ^ Betre, H; Liu, W; Zalutsky, MR; Chilkoti, A; Kraus, VB; Setton, LA (2006). "A thermally responsive biopolymer for intra-articular drug delivery". J Control Release. 115 (2): 175–182. doi:10.1016/j.jconrel.2006.07.022. PMID 16959360.
  17. ^ Allen, KD; Shamji, MF; Mata, BA; Gabr, MA; Sinclair, SM; Schmitt, DO; Richardson, WJ; Setton LA (2011). "Kinematic and dynamic gait compensations in a rat model of lumbar radiculopathy and the effects of tumor necrosis factor-alpha antagonism". Arthritis Research & Therapy. 13 (4): R137. doi:10.1186/ar3451. PMC 3239380. PMID 21871102.
  18. ^ Goolge Scholar Citations for Lori Setton
  19. ^ Duke University Graduate School (2005). "Dean's Awards for Excellence in Mentoring: Past Recipients". gradschool.duke.edu. Archived from the original on 2013-10-20. Retrieved 2013-05-22.
  20. ^ bmes.org (2009). "BMES Fellows". Biomedical Engineering Society. Retrieved 2013-05-23.
  21. ^ asme.org (2007). "Van C. Mow Medal Recipients". American Society of Mechanical Engineers. Retrieved 2013-05-23.
  22. ^ gradschool.duke.edu (2004). "Dean's Awards for Excellence in Mentoring: Past Recipients". Duke University Graduate School. Retrieved 2013-05-23.
  23. ^ www.pratt.duke.edu (2001). "Duke Engineering Faculty Awards". Duke University School of Engineering. Retrieved 2013-05-23.
  24. ^ www.nsf.gov (1997-10-24). "Twenty NSF-Supported Young Scientists and Engineers Receive Presidential Award". National Science Foundation. Retrieved 2013-05-25.

External links[edit]

  • Washington University: [1] Lori A. Setton, Department of Biomedical Engineering