Lori Ann Setton

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Lori Ann Setton
Born Queens, New York, US
Nationality American
Fields Biomechanical Engineer
Institutions Duke University
Alma mater Princeton University
Columbia University
Doctoral advisor Van C. Mow
Known for mechanics
mechanobiology of the intervertebral disc
articular cartilagemechanics
drug delivery
pathomechanisms of osteoarthritis
Notable awards AIMBE Fellow (2005)
BMES Fellow (2009)
Van C. Mow Medal(2007)

Lori Ann Setton (born December 1, 1962) is an American biomechanical engineer noted for her research on mechanics and mechanobiology of the intervertebral disc, articular cartilage mechanics, drug delivery, and pathomechanisms of osteoarthritis.


Setton was born in Queens, New York. She received a B.S.E. in Mechanical and Aerospace Engineering from Princeton University in 1984. She received a M.S. in Mechanical Engineering/Biomechanics from Columbia University in 1988 and a Ph.D in Mechanical Engineering/Biomechanics from Columbia University in 1993.

She joined the Department of Biomedical Engineering at Duke University as an Assistant Professor in 1995. She was promoted to associate professor in 2004, and professor in 2007.

Her most noticeable work has documented the biological responses of cartilage and intervertebral disc to mechanical loading[1][2][3][4][5][6] understanding a role for collagen genetic mutations in onset of arthritis and intervertebral disc pathology[7][8] development of injectable hydrogels for articular cartilage repair[9][10][11][12] and development of injectable drug delivery vehicles for fighting inflammation in musculoskeletal disease.[13][14][15][16][17]


Setton has several awards:

  • Dean's Award for Excellence in Mentoring, Duke Graduate School(2004)[21]
  • Stansell Family Distinguished Research Award (2001)[22]
  • Presidential Early Career Awards for Scientists and Engineers (PECASE) (1997) for "Leadership in education and research in understanding and restoring biomechanical functions to tissue degenerated by injury or aging, especially in the spine[23]


  1. ^ Setton, LA; Chen, J (2006). "Mechanobiology of the intervertebral disc and relevance to disc degeneration". J Bone Joint Surg Am 88 (2): 52–57. doi:10.2106/JBJS.F.00001. PMID 16595444. 
  2. ^ Setton, LA; Mow, VC; Müller, FJ; Pita, JC; Howell, DS (1994). "Mechanical properties of canine articular cartilage are significantly altered following transection of the anterior cruciate ligament". Journal Orthopedic Research 12 (4): 451–463. doi:10.1002/jor.1100120402. PMID 8064477. 
  3. ^ LeRoux, MA; Arokoski, J; Vail, TP; Guilak, F; Hyttinen, MM; Kiviranta, I; Setton, LA (2000). "Simultaneous changes in the mechanical properties, quantitative collagen organization, and proteoglycan concentration of articular cartilage following canine meniscectomy". Journal of Orthopedic Research 18 (3): 383–392. doi:10.1002/jor.1100180309. PMID 10937624. 
  4. ^ Leroux, MA; Cheung, HS; Bau, JL; Wang, JY; Howell, DS; Setton, LA (2001). "Altered mechanics and histomorphometry of canine tibial cartilage following joint immobilization". Osteoarthritis Cartilage 9 (7): 633–640. doi:10.1053/joca.2001.0432. PMID 11597176. 
  5. ^ Boyd, LM; Richardson, WJ; Chen, J; Kraus, VB; Tewari, A; Setton, LA (2005). "Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real-time quantitative RT-PCR". Annals of Biomedical Engineering 33 (8): 1071–1077. doi:10.1007/s10439-005-5775-y. PMID 16133915. 
  6. ^ Chen, J; Yan, W; Setton, LA (2004). "Static compression induces zonal-specific changes in gene expression for extracellular matrix and cytoskeletal proteins in intervertebral disc cells in vitro". Matrix Biology 22 (7): 573–583. doi:10.1016/j.matbio.2003.11.008. PMID 14996437. 
  7. ^ Boyd, LM; Richardson, WJ; Allen, KD; Flahiff, C; Jing, L; Li, Y; Chen, J; Setton, LA (2008). "Early-onset degeneration of the intervertebral disc and vertebral end plate in mice deficient in type IX collagen". Arthritis Rheum 58 (1): 164–171. doi:10.1002/art.23231. PMID 18163498. 
  8. ^ Allen, KD; Griffin, TM; Rodriguiz, RM; Wetsel, WC; Kraus, VB; Huebner, JL; Boyd LM; Setton, LA (2009). "Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen". Arthritis Rheum 60 (9): 2684–2693. doi:10.1002/art.24783. PMC 2760314. PMID 19714629. 
  9. ^ Nettles, DL; Chilkoti, A; Setton, LA (2010). "Applications of elastin-like polypeptides in tissue engineering". Adv Drug Deliv Rev 62 (15): 1479–1485. doi:10.1016/j.addr.2010.04.002. PMID 20385185. 
  10. ^ Nettles DL; Kitaoka, K; Hanson, NA; Flahiff, CM; Mata, BA; Hsu, EW; Chilkoti, A; Setton, LA (2008). "In situ crosslinking elastin-like polypeptide gels for application to articular cartilage repair in a goat osteochondral defect model". Tissue Eng Part A 14 (7): 1133–1140. doi:10.1089/tea.2007.0245. PMC 3312393. PMID 18433311. 
  11. ^ Betre, H; Ong, SR; Guilak, F; Chilkoti, A; Fermor, B; Setton, LA (2006). "Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide". Biomaterials 27 (1): 91–99. doi:10.1016/j.biomaterials.2005.05.071. PMID 16023192. 
  12. ^ Nettles, DL; Vail, TP; Morgan, MT; Grinstaff, MW; Setton LA (2004). "Photocrosslinkable hyaluronan as a scaffold for articular cartilage repair". Ann Biomed Eng 32 (3): 391–397. doi:10.1023/b:abme.0000017552.65260.94. PMID 15095813. 
  13. ^ Allen, KD; Adams, SB Jr; Mata, BA; Shamji, MF; Gouze, E; Jing, L; Nettles, DL; Latt, LD; Setton, LA (2010). "Gait and behavior in an IL1β-mediated model of rat knee arthritis and effects of an IL1 antagonist". Journal of Orthopedic Research 29 (5): 694–703. doi:10.1002/jor.21309. PMC 3100769. PMID 21437948. 
  14. ^ Shamji, MF; Chen, J; Friedman, AH; Richardson, WJ; Chilkoti, A; Setton, LA (2008). "Synthesis and characterization of a thermally-responsive tumor necrosis factor antagonist". J Control Release 129 (3): 179–186. doi:10.1016/j.jconrel.2008.04.021. PMC 2637771. PMID 18547669. 
  15. ^ Shamji, MF; Betre, H; Kraus, VB; Chen, J; Chilkoti, A; Pichika, R; Masuda, K; Setton LA (2007). "Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic". Arthritis Rheum 56 (11): 3650–3661. doi:10.1002/art.22952. PMID 17968946. 
  16. ^ Betre, H; Liu, W; Zalutsky, MR; Chilkoti, A; Kraus, VB; Setton, LA (2006). "A thermally responsive biopolymer for intra-articular drug delivery". J Control Release 115 (2): 175–182. doi:10.1016/j.jconrel.2006.07.022. PMID 16959360. 
  17. ^ Allen, KD; Shamji, MF; Mata, BA; Gabr, MA; Sinclair, SM; Schmitt, DO; Richardson, WJ; Setton LA (2011). "Kinematic and dynamic gait compensations in a rat model of lumbar radiculopathy and the effects of tumor necrosis factor-alpha antagonism". Arthritis Res Ther 13 (4): R137. doi:10.1186/ar3451. PMC 3239380. PMID 21871102. 
  18. ^ Duke University Graduate School (2005). "Dean's Awards for Excellence in Mentoring: Past Recipients". gradschool.duke.edu. Retrieved 2013-05-22. 
  19. ^ bmes.org (2009). "BMES Fellows". Biomedical Engineering Society. Retrieved 2013-05-23. 
  20. ^ asme.org (2007). "Van C. Mow Medal Recipients". American Society of Mechanical Engineers. Retrieved 2013-05-23. 
  21. ^ gradschool.duke.edu (2004). "Dean's Awards for Excellence in Mentoring: Past Recipients". Duke University Graduate School. Retrieved 2013-05-23. 
  22. ^ www.pratt.duke.edu (2001). "Duke Engineering Faculty Awards". Duke University School of Engineering. Retrieved 2013-05-23. 
  23. ^ www.nsf.gov (1997-10-24). "Twenty NSF-Supported Young Scientists and Engineers Receive Presidential Award". National Science Foundation. Retrieved 2013-05-25. 

External links[edit]

  • Duke University: [1] Lori A. Setton, Department of Biomechanical Engineering