Los Santos could refer to:
- Los Santos Province, Panama
- Los Santos District, Los Santos Province, Panama
- La Villa de los Santos, capital city of Los Santos District, Panama
- Los Santos de Maimona, municipality in Badajoz, Extremadura, Spain
- Los Santos, a municipality in the province of Salamanca, Castile and León, Spain.
- Los Santos de la Humosa, a municipality of the Community of Madrid in Spain.
- Los Santos, a municipality in the department of Santander, Colombia.
- Los Santos, San Andreas, fictional city within the video games Grand Theft Auto: San Andreas and Grand Theft Auto V
|This disambiguation page lists articles about distinct geographical locations with the same name.
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