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Clinical data
Trade namesCredelio, Credelio Cat
License data
Routes of
By mouth
ATCvet code
Legal status
Legal status
  • 3-Methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]thiophene-2-carboxamide
CAS Number
PubChem CID
Chemical and physical data
Molar mass596.75 g·mol−1
3D model (JSmol)
  • Cc1cc(C2=NO[C@@](c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)sc1C(=O)NCC(=O)NCC(F)(F)F
  • InChI=1S/C20H14Cl3F6N3O3S/c1-8-2-13(36-16(8)17(34)30-6-14(33)31-7-19(24,25)26)12-5-18(35-32-12,20(27,28)29)9-3-10(21)15(23)11(22)4-9/h2-4H,5-7H2,1H3,(H,30,34)(H,31,33)/t18-/m0/s1

Lotilaner, sold under the brand name Credelio, is a veterinary medication used to control fleas and ticks in dogs and cats.[1][2][3][4] It is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and for the treatment and control of tick infestations including lone star tick (Amblyomma americanum), American dog tick (Dermacentor variabilis), black-legged tick (Ixodes scapularis), and brown dog tick (Rhipicephalus sanguineus).[5]

Lotilaner in combination with milbemycin oxime is sold under the brand name Credelio Plus.[6] It is used in dogs to treat concurrent infestations with parasites living outside (ticks and/or fleas) and inside (worms) the animal's body.[6]


  1. ^ a b "Credelio- lotilaner tablet, chewable". DailyMed. Retrieved 4 August 2021.
  2. ^ a b "Credelio- lotilaner tablet, chewable". DailyMed. Retrieved 4 August 2021.
  3. ^ a b "Credelio EPAR". European Medicines Agency. Retrieved 4 August 2021.
  4. ^ Kuntz EA, Kammanadiminti S (November 2017). "Safety evaluation of lotilaner in dogs after oral administration as flavoured chewable tablets (Credelio)". Parasites & Vectors. 10 (1): 538. doi:10.1186/s13071-017-2468-y. PMC 5664904. PMID 29089043.
  5. ^ "Freedom Of Information Summary, Supplemental New Animal Drug Application, NADA 141-494, Credelio, Lotilaner, Chewable Tablets, Dogs". 3 September 2019.
  6. ^ a b "Credelio Plus EPAR". European Medicines Agency. 19 February 2021. Retrieved 4 August 2021. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

External links[edit]

  • "Lotilaner". Drug Information Portal. U.S. National Library of Medicine.