After de Gaulle's return to power in 1958, he was appointed Minister of State in charge of scientific research and afterwards for the Sahara. As Minister of State, he was part of a "study group" formed by de Gaulle with the purpose of devising a constitution for the Fifth Republic. Later he again held the position of Minister for Overseas France (1961–66). He also chaired the General Council of the Meuse department in the Lorraine Province. A moderate right-wing politician during the Third and Fourth Republics, during the de Gaulle era, he voted with Giscard d'Estaing's independent republicans and later as a member of the Gaullist Union of Democrats for the Fifth Republic. He left parliament in 1973. Jacquinot married the wife of former Finance Minister Maurice Petsche in order to be elected president that year, but he was homosexual. He died in Paris in 1993.