The original song, "Love in This Club", was sung by Usher, with guest vocals from rapper Young Jeezy also present. It was written by Usher, Polow da Don, Lamar Taylor, Young Jeezy, Ryon Lovett, Keith Thomas and Darnell Dalton, with da Don producing the track. The remix features additional writing from Lil Wayne, with Soundzproducing the track. Usher said in an interview with MTV of the song, "I wanted it to be something that would be a surprise, be a shock. Have shock value. That's what the remix is all about." On working with Beyoncé Knowles, he said, "It's a treat for me. I've been wanting for years to do a record with Beyoncé. Even though it's a remix, it's a really special record for me". He also spoke highly of Wayne, dubbing him "one of the illest in the game". The song was originally intended to be sung by Usher with Mariah Carey and rapper Plies. While Plies had recorded two verses for the song, he and Carey did not appear on the final cut, with Knowles and Wayne featuring instead. Rumours also surfaced that R&B singer Keri Hilson would make an appearance on the tune. The song, one of the last additions to Here I Stand, was recorded at Hitland Studios in Alpharetta and The Record Plant in Los Angeles.
The tempo of "Love in This Club Part II" is much slower than that of the original song.Idolator compared the slowing-down to the remixing of R. Kelly's "Ignition" (2002). Usher has said that he likes Part II more than the original. The tune samples The Stylistics' 1971 number "You Are Everything", written by Thom Bell and Linda Creed. The lyrics and theme of the song are similar to those of Part I, with Serena Kim of The Washington Post describing it as "mighty pressure coming from...male voices to persuade one woman to succumb to spontaneous sex", while Knowles portrays herself as a "hesitant but willing" voice of reason. Wayne's lyrics, modified through the use of a vocoder to make him sound intoxicated, are wily seductions to have his love interest have intercourse with him in the club's bathroom. During Wayne's verse, Usher sings breathy ad-libs. In the song, Usher refers to Knowles as "Queen B".
Shaheem Reid of MTV News praised Wayne's vocals as a repeat of his melodic success on "Lollipop". YoRapper.com also appreciated Wayne's effort, saying "aside from sounding like he's dying, he delivers an entertaining verse."Stuff liked the way that his presence offered relief from the ballads on Here I Stand.About.com's Mark Nero lauded the song as being "much better than the original version", noting Knowles' appearance as "regal", while Idolator also praised the collaboration with Knowles and Wayne as "much better" than that with Young Jeezy, who appeared on the original track. Steve Jones of USA Today picked "Love in This Club Part II" as a standout track of Here I Stand.
However, Josh Eells of Blender was not impressed, writing that the song "manages to make two of the most desirable people on the planet [Usher and Knowles] sound chaste", while IGN's Chad Grischow called the record "bland" and "lacking at best". Simon Vozick-Levinson from Entertainment Weekly criticized Usher's pick-up lines, describing them as more ridiculous than in the original song, as well as Wayne's reusing of lyrics from both "Lollipop" and his remix of "Crying Out for Me" (2007) by Mario. On the other hand, Vozick-Levinson commended Knowles' vocal performance on the track. Joey Guerra of the Houston Chronicle said that Knowles' vocal was the clear standout on the song. The song was listed as 36 in the Rolling Stone's The 100 Best Song of 2008.
"Love in This Club Part II" debuted on the United States Billboard Hot 100 at number seventy-nine on the issue dated May 10, 2008, due to high radio airplay and digital sales. It climbed the chart, reaching its peak position of number eighteen three weeks later. "Love in This Club Part II" slipped off the chart after twenty-two weeks. On the Hot R&B/Hip-Hop Songs, the song debuted at number fourteen the same week. It peaked on the chart at number seven on June 21, 2008, gaining the 'Digital Gainer' honor the same week. It gave Usher his thirteenth top ten song on the component chart and lasted thirty-four weeks on the chart. The song appeared on the Pop 100, where it peaked at number thirty-five. "Love in This Club Part II" was certified gold by the Recording Industry Association of America (RIAA) on October 8, 2008, for sales of over 500,000 master tones. As of October 3, 2010, it has sold 366,000 digital music downloads in the United States, according to Nielsen SoundScan. On May 31, 2008, the song debuted and peaked on the Canadian Hot 100 at number sixty-nine, and fell off the chart four weeks later. In Australia, "Love in This Club Part II" debuted and peaked on the ARIA Singles Chart at number ninety-six on the chart dated June 9, 2008.