Low-intensity pulsed ultrasound
Low-intensity pulsed ultrasound (LIPUS) is a medical technology, generally using 1.5 MHz frequency pulses, with a pulse width of 200 μs, repeated at 1 kHz, at a spatial average and temporal average intensity of 30 mW/cm2, 20 minutes/day.
Applications of LIPUS include:
- Promoting bone-fracture healing.
- Treating orthodontically induced root resorption.
- Regrow missing teeth.
- Enhancing mandibular growth in children with hemifacial microsomia.
- Promoting healing in various soft tissues such as cartilage, inter vertebral disc.
- Improving muscle healing after laceration injury.
Researchers at the University of Alberta have used LIPUS to gently massage teeth roots and jawbones to cause growth or regrowth, and have grown new teeth in rabbits after lower jaw surgical lengthening (Distraction osteogenesis) (American Journal of Orthodontics, 2002). As of June 2006, a larger device has been licensed by the Food and Drug Administration (FDA) and Health Canada for use by orthopedic surgeons. A smaller device that fits on braces has also been developed but is still in the investigational stage and is not available to the public.
Lipus is used in the Exogen bone stimulator for use in acute fractures and nonunions of bone. It has not yet been approved by either Canadian or American regulatory bodies for teeth and a market-ready model is currently being prepared. LIPUS was expected to be commercially available before the end of 2012. The LIPUS foundation website currently announces that Lipus-Plasma application units are available for rental in the USA. Though reports from the University of Alberta and the independent company SmileSonica indicate that the owner of the LIPUS foundation has no affiliation with the medical community.
According to Dr. Chen from the University of Alberta, LIPUS may also have medical/cosmetic benefits in allowing people to grow taller by stimulating bone growth. However it has not been shown to be able to help in bone longitudinal growth when combined with bioengineered cartilage pellets for growth plate induced fractures 
- Raman Mundi; Stephen Petis; Roopinder Kaloty; Vijay Shetty; Mohit Bhandari (2009). "Low-intensity pulsed ultrasound: Fracture healing". Indian J Orthop 43 (2): 132–140. doi:10.4103/0019-5413.50847. PMC 2762261. PMID 19838361.
- El-Bialy T, El-Shamy I, Graber (2004). "Repair of orthodontically induced root resorption by ultrasound in humans". Am J Orthod Dentofacial Orthop 126 (2): 186–193. doi:10.1016/S0889540604002872. PMID 15316473.
- Rego, E. B. (2012). "Current Status of Low Intensity Pulsed Ultrasound for Dental Purposes". The Open Dentistry Journal 6: 220–5. doi:10.2174/1874210601206010220. PMC 3547311. PMID 23341848.
- Tarek El-Bialy; Ali Hasan; Ahmad Janadas; Tarik Albaghdad (March 2010). "Nonsurgical treatment of hemifacial microsomia by therapeutic ultrasound and hybrid functional appliance". Br Med Bull 2010 (2): 29–36. doi:10.2147/OAJCT.S7060.
- Anil Khanna; Richard T. C. Nelmes; Nikolaos Gougoulias; Nicola Maffulli; Jim Gray (2009). "The effects of LIPUS on soft-tissue healing: a review of literature". Br Med Bull 89 (1): 169–182. doi:10.1093/bmb/ldn040.
- Yi-Sheng Chan; Kuo-Yao Hsu; Chia-Hua Kuo; Shin-Da Lee; Su-Ching Chen; Wen-Jer Chen; Steve Wen-Neng Ueng (May 2010). "Using Low-Intensity Pulsed Ultrasound to Improve Muscle Healing After Laceration Injury: An in vitro and in vivo Study". Ultrasound in Medicine and Biology 36 (5): 743–751. doi:10.1016/j.ultrasmedbio.2010.02.010.
- Chow, S. K.; Lee, K. M.; Qin, L; Leung, K. S.; Cheung, W. H. (2011). "Restoration of longitudinal growth by bioengineered cartilage pellet in physeal injury is not affected by low intensity pulsed ultrasound". Journal of Biomedical Materials Research Part B: Applied Biomaterials 99 (1): 36–44. doi:10.1002/jbm.b.31869. PMID 21681954.
- Korstjens, C. M.; Van Der Rijt, R. H.; Albers, G. H.; Semeins, C. M.; Klein-Nulend, J (2008). "Low-intensity pulsed ultrasound affects human articular chondrocytes in vitro". Medical & Biological Engineering & Computing 46 (12): 1263–70. doi:10.1007/s11517-008-0409-9. PMID 18853213.
- Canadians go ultrasonic for tooth regrowth implant Chris Williams (The Register) June 29, 2006
- Ultrasound May Help Regrow Teeth University of Alberta (Science Daily) June 28, 2006
- Low Intensity Pulsed Ultra Sound - Homepage of Mr. Matuschka's LIPUS foundation
- Low Intensity Pulsed UltraSound - LIPUS.info
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