Low-intensity pulsed ultrasound (LIPUS) is a medical technology, generally using 1.5 MHz frequency pulses, with a pulse width of 200 μs, repeated at 1 kHz, at a spatial average and temporal average intensity of 30 mW/cm2. As of 2009 research for the use of LIPUS to treat soft tissue injuries were in the early stages. As of 2012 it was being studied for dental problems.
A 2017 review recommended against its use to speed healing of bone fractures. Evidence as of 2014 was insufficient to justify its use to prevent non healing of bone fractures. Tentative evidence supports better healing with the use of the system in long bones that have no health after three months.
^Poolman, RW; Agoritsas, T; Siemieniuk, RA; Harris, IA; Schipper, IB; Mollon, B; Smith, M; Albin, A; Nador, S; Sasges, W; Schandelmaier, S; Lytvyn, L; Kuijpers, T; van Beers, LW; Verhofstad, MH; Vandvik, PO (21 February 2017). "Low intensity pulsed ultrasound (LIPUS) for bone healing: a clinical practice guideline.". BMJ (Clinical research ed.). 356: j576. PMID28228381.
^Griffin, XL; Parsons, N; Costa, ML; Metcalfe, D (23 June 2014). "Ultrasound and shockwave therapy for acute fractures in adults.". The Cochrane database of systematic reviews (6): CD008579. PMID24956457.
^Higgins, A; Glover, M; Yang, Y; Bayliss, S; Meads, C; Lord, J (October 2014). "EXOGEN ultrasound bone healing system for long bone fractures with non-union or delayed healing: a NICE medical technology guidance.". Applied health economics and health policy. 12 (5): 477–84. PMID25060830.