|AHFS/Drugs.com||International Drug Names|
|Elimination half-life||75 minutes|
|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||246.302 g/mol|
304.314 g/mol (sodium salt as the dihydrate) g·mol−1
|3D model (JSmol)|
|(what is this?)|
Loxoprofen is a nonsteroidal anti-inflammatory drug (NSAID) in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. It is available in these countries for oral administration, and a transdermal preparation was approved for sale in Japan on January 2006.
It was patented in 1977 and approved for medical use in 1986.
Mechanism of action
Loxoprofen should not be administered at the same time as second-generation quinolone antibiotics such as ciprofloxacin and norfloxacin, as it increases their inhibition of GABA and this may cause seizures. It may also increase the plasma concentration of warfarin, methotrexate, sulfonylurea derivatives and lithium salts, so care should be taken when loxoprofen is administered to patients taking any of these drugs.
- Daiichi Sankyo Co. (January 24, 2006). "Percutaneous Absorption-Type Analgesic and Anti-inflammatory Drug Loxonin Poultice 100mg Receives Approval for Manufacture" (Press release). Doctor's Guide Global Edition. Retrieved 2007-04-19.
- Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 521. ISBN 9783527607495.
- "LOXONIN - Bula do Medicamento [Label Information]" (in Portuguese). Centralx. 2007. Retrieved 2007-04-19.
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