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Loxoprofen 3D.png
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
Oral, transdermal
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding97%
MetabolismHepatic glucuronidation
Elimination half-life75 minutes
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass246.302 g/mol
304.314 g/mol (sodium salt as the dihydrate) g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
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Loxoprofen is a nonsteroidal anti-inflammatory drug (NSAID) in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. It is available in these countries for oral administration, and a transdermal preparation was approved for sale in Japan on January 2006.[1]

It was patented in 1977 and approved for medical use in 1986.[2]


Loxoprofen is a prodrug. It is quickly converted to its active trans-alcohol metabolite following oral administration, and reaches its peak plasma concentration within 30 to 50 minutes.

Mechanism of action[edit]

As most NSAIDs, loxoprofen is a non-selective cyclooxygenase inhibitor, and works by reducing the synthesis of prostaglandins from arachidonic acid.


Loxoprofen should not be administered at the same time as second-generation quinolone antibiotics such as ciprofloxacin and norfloxacin, as it increases their inhibition of GABA and this may cause seizures.[3] It may also increase the plasma concentration of warfarin, methotrexate, sulfonylurea derivatives and lithium salts, so care should be taken when loxoprofen is administered to patients taking any of these drugs.[3]

Brand names[edit]

It is marketed in Brazil, Mexico and Japan by Sankyo as its sodium salt, loxoprofen sodium, under the trade name Loxonin, in Argentina as Oxeno, in India as Loxomac, and in Thailand as Japrolox.


  1. ^ Daiichi Sankyo Co. (January 24, 2006). "Percutaneous Absorption-Type Analgesic and Anti-inflammatory Drug Loxonin Poultice 100mg Receives Approval for Manufacture" (Press release). Doctor's Guide Global Edition. Retrieved 2007-04-19.
  2. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 521. ISBN 9783527607495.
  3. ^ a b "LOXONIN - Bula do Medicamento [Label Information]" (in Portuguese). Centralx. 2007. Retrieved 2007-04-19.