|Date of birth||21 February 1987|
|Place of birth||Seregno, Italy|
|2006||→ Varese (loan)||9||(0)|
|2011||Aquanera Comollo Novi||6||(1)|
|2006–2007||Italy U20 Serie C||1+||(0)|
|* Senior club appearances and goals counted for the domestic league only.
Born in Seregno, the Province of Monza and Brianza (historically part of the Province of Milan), Palazzo joined Internazionale in 2004. At first he was the member of Berretti U18 reserve team (B team of U20 age group) but later promoted to Primavera U20 team. Palazzo played all 3 matches of the playoffs, losing to Empoli in the quarter-finals. Palazzo also capped for Inter first team in club friendlies. However, he only played 3 times in 2005–06 season for Primavera.
In January 2006 Palazzo was transferred to Serie D club Varese in temporary deal. In mid-2006, Palazzo was signed by Serie C1 club Pro Sesto in co-ownership deal for a peppercorn fee of €1,000. Born 1988 players Marco Dalla Costa, Daniele Federici, Nicola Redomi, Alessandro Brioschi, Alessio Colombo and Alessandro Mosca also joined the club as they were the surplus of Primavera.
Palazzo made his professional debut with the tiny Lombardy club Pro Sesto. He made 23 starts (28 appearances) in 2006–07 Serie C1. In June 2007 Inter gave up the remain 50% registration rights for free. However in the new season Palazzo only played 4 times.
In mid-2008 Palazzo was re-signed by Varese. However Palazzo only played 8 times for the group A champion of Lega Pro Seconda Divisione (ex- Serie C2). Palazzo made a single appearance in 2009–10 Lega Pro Prima Divisione. In January 2010 Palazzo was signed by Valenzana. Palazzo played 35 times for the Piedmont in 1½ seasons in Lega Pro Seconda Divisione. He was offered a new contract on 21 July 2010. However his contract was not renewed at the start of 2011–12 season.
Palazzo was released by the Valenza based club on 30 June 2011. He joined a Serie D club Aquanera Comollo Novi (Italian fifth division). The team was based in Novi Ligure (new Liguria), also from the same province where Valenza is located. However in mid-season the club was expelled from the league due to irregularity in the registration documents submitted at the start of the league. In January 2012 Palazzo moved south, signing a deal with Eccellenza Liguria club Pontedecimo (Italian sixth division). The club was based in the quartiere of the same name, from Genoa, the capital of Liguria region.
Palazzo capped for Italy youth teams after he joined Internazionale. He was the member of Italy national under-18 football team, the feeder team of U19. However his poor performance in the 2005–06 led to him being left out of the U19 squad.
After joined Pro Sesto, Palazzo was spotted by the "C" team of U20, the representative team of Serie C. He received a call-up to the second match of 2006–07 Mirop Cup against Slovenia (on bench, substitute record not available). He also received call-up from the same team for 2007 Lega Pro Quadrangular Tournament, against three other U21 representative teams of Serie C2. However, did not play. Palazzo received his last call-up against Belgium, which he was the starting midfielder.
- "CRUZ SCORES TWO AS INTER BEAT SPEZIA 3-1". www.inter.it. FC Internazionale Milano. 24 March 2005. Retrieved 25 March 2012.
- "TRANSFERS: SIX MORE DEALS DONE". www.inter.it. FC Internazionale Milano. 31 January 2006. Retrieved 25 March 2012.
- FC Internazionale Milano Report and Accounts on 30 June 2007 (Italian), Require purchase in CCIAA
- "Transfer market: co-ownership deals". www.inter.it. FC Internazionale Milano. 20 June 2007. Retrieved 25 March 2012.
- "Preso Palazzo" (in Italian). Valenzana Calcio. 8 January 2010. Retrieved 26 March 2012.
- "Riconfermato Luca Palazzo" (in Italian). Valenzana Calcio. 21 July 2010. Retrieved 26 March 2012.
- "L'ex Aquanera Luca Palazzo scende in Eccellenza" (in Italian). notiziariocalcio.com. 22 January 2012. Retrieved 25 March 2012.
- "TORNEO "ALPE ADRIA MIROP CUP"" (PDF) (in Italian). Lega Calcio Serie C. 25 October 2006. Retrieved 25 March 2012.
- "no title (Call-up of Italy U20 C, Serie C1 and Serie C2 representative teams for Serie C1 U21 Tournament and Serie C Quadrangular Tournament)" (PDF) (in Italian). Lega Calcio Serie C. 23 January 2007. Retrieved 25 March 2012.
- "Gara amichevole Belgio Under 20 - Italia C Under 20" (PDF) (in Italian). Lega Calcio Serie C. 12 February 2007. Retrieved 25 March 2012.