The station was a major stopping point on the South Main Line for PNR intercity services until the line's closure in 2006 after Typhoon Milenyo damaged infrastructure. It served both the Bicol Express and the Mayon Limited. It is near the Quezon Provincial Government Center, which houses the provincial government of Quezon, as well as Perez Park and the Lucena Fire Station. Further away from the station are the Port of Lucena, the Lucena Airport and SM City Lucena.
Lucena station was also home to a PNR depot and maintenance facilities.