Lucey–Driscoll syndrome

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Lucey–Driscoll syndrome
Other namesTransient familial neonatal hyperbilirubinemia
Autorecessive.svg
Lucey–Driscoll syndrome has an autosomal recessive pattern of inheritance.
SpecialtyDiseasesDB = 32677

Lucey–Driscoll syndrome is an autosomal recessive metabolic disorder affecting enzymes involved in bilirubin metabolism.[1] It is one of several disorders classified as a transient familial neonatal unconjugated hyperbilirubinemia.

Cause[edit]

The common cause is congenital, but it can also be caused by maternal steroids passed on through breast milk to the newborn. It is different from breast feeding-associated jaundice (breast-fed infants have higher bilirubin levels than formula-fed ones).

Genetics[edit]

A defect in the UGT1A1-gene, also linked to Crigler–Najjar syndrome and Gilbert's syndrome, is responsible for the congenital form of Lucey–Driscoll syndrome.

Diagnosis[edit]

Treatment[edit]

References[edit]

  1. ^ "Lucey-Driscoll syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Retrieved 2017-08-27.

External links[edit]

Classification
External resources