Lucey–Driscoll syndrome

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Lucey–Driscoll syndrome
Classification and external resources
ICD-9-CM 774.30
OMIM 237900
DiseasesDB 32677

Lucey–Driscoll syndrome is an autosomal recessive metabolic disorder affecting enzymes involved in bilirubin metabolism. It is one of several disorders classified as a transient familial neonatal unconjugated hyperbilirubinemia.


The common cause is congenital, but it can also be caused by maternal steroids passed on through breast milk to the newborn. It is different from breast feeding-associated jaundice (breast-fed infants have higher bilirubin levels than formula-fed ones).


Lucey–Driscoll syndrome has an autosomal recessive pattern of inheritance.

A defect in the UGT1A1-gene, also linked to Crigler–Najjar syndrome and Gilbert's syndrome, is responsible for the congenital form of Lucey–Driscoll syndrome.

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