He worked as a railway station caretaker until the early 1970s, when he met Italo Allodi, then Juventus' managing director, who appointed him to minor roles at the club.
Before being called as chief managing director by Juventus in 1994, he worked for and collaborated with several teams, such as Torino, Napoli, Roma and Lazio. He has a son Alessandro, who works as an agent for several football players and managers. He is head of GEA World, a consortium of football agents and managers, which the company and Alessandro were ranked the first by volume from 2002 to 2006. He was nicknamed by Italian journalist Marco Travaglio as "Lucky Luciano", a reference to the notorious gangster.
In 2006 he was the main figure involved in a football scandal, after the publication of several wiretappings in which he suggested and asked for particular referees' names to Pierluigi Pairetto, the former Italian referee nominator. The scandal, which also involved his son, undermined the figure of Moggi, and fueled several inquiries by the judicial courts of Rome and Naples. As a consequence of the scandal, which is still unfolding, the Italian Football Federation president Franco Carraro and the president of the Italian Referee Association both resigned. As for Moggi, after the 2006 season's final match of his team against Reggina, he announced that he would resign from his position and would retire from the world of football altogether:
I don't have either the strength nor the willingness to answer any question. I miss my soul, it has been killed. Tomorrow I'll be resigning, since tonight the football world isn't my world anymore. I'll think only to defend myself from all allegations and wicked actions.
Moggi has spoken out against gay footballers, saying that: "A homosexual can't fulfil the job of a footballer. I wouldn't put one under contract and if I discovered I had one, he would fly immediately."
During his Napoli administration, he won the following trophies:
- 1 Scudetto
- 1 UEFA Cup
- 1 Italian Supercup
During his Torino administration, he won the following trophies:
- 1 Mitropa Cup
- 1 Italian Cup
During his Juventus administration, he won the following trophies:
- 5 Scudetti (+2 revoked)
- 1 Italian Cup
- 4 Italian Supercup
- 1 Intercontinental Cup
- 1 Champions League
- 1 European Supercup
- 1 UEFA Intertoto Cup
- "Moggi sentenced over match-fixing". FourFourTwo. 2011-11-08. Retrieved 2012-11-18.
- "Bollettino: Settmanale 2006". Trasp-statistiche/doc. Retrieved 2012-11-18.
- "I'd nail Juventus' third golden star to Moratti's head, says Moggi". Goal.com. 2012-05-09. Retrieved 2012-11-18.
- "Juventus defiant in match-fix controversy - CNN.com". Edition.cnn.com. Retrieved 2012-11-18.
-  Archived July 8, 2009 at the Wayback Machine
- "Radio Mana' Mana'". Storiaradiotv.it. Retrieved 2012-11-18.
- Kate Connolly in Berlin (2010-11-14). "Croatia football chief Vlatko Markovic hit by gay group's backlash | Football | The Observer". Guardian. Retrieved 2012-11-18.
- Jonathan O'Brien, The Sunday Business Post, 16 July 2006, "The Italian Job"
- Jason Burke, The Observer, 30 July 2006, "Paradiso to inferno"