Luciferin (from the Latin lucifer, "light-bringer") is a generic term for the light-emitting compound found in organisms that generate bioluminescence. Luciferins typically undergo an enzyme-catalysed oxidation and the resulting excited state intermediate emits light upon decaying to its ground state. This may refer to molecules that are substrates for both luciferases and photoproteins.
Luciferins are a class of small-molecule substrates that are oxidized in the presence of the enzyme luciferase to produce oxyluciferin and energy in the form of light. It is not known just how many types of luciferins there are, but some of the better-studied compounds are listed below. There are many types of luciferins, yet all share the use of reactive oxygen species to emit light.
Firefly luciferin is the luciferin found in many Lampyridae species. It is the substrate of luciferase (EC 220.127.116.11) responsible for the characteristic yellow light emission from fireflies. The chemistry is unusual, as adenosine triphosphate (ATP) is required for light emission.
Coelenterazine is found in radiolarians, ctenophores, cnidarians, squid, brittle stars, copepods, chaetognaths, fish, and shrimp. It is the prosthetic group in the protein aequorin responsible for the blue light emission.
Dinoflagellate luciferin is a chlorophyll derivative (i. e. a Tetrapyrrole) and is found in some dinoflagellates, which are often responsible for the phenomenon of nighttime glowing waves (historically this was called phosphorescence, but is a misleading term). A very similar type of luciferin is found in some types of euphausiid shrimp.
- Hastings JW (1996). "Chemistries and colors of bioluminescent reactions: a review". Gene. 173 (1 Spec No): 5–11. doi:10.1016/0378-1119(95)00676-1. PMID 8707056.
- Hastings JW (1983). "Biological diversity, chemical mechanisms, and the evolutionary origins of bioluminescent systems". J. Mol. Evol. 19 (5): 309–21. doi:10.1007/BF02101634. PMID 6358519.
- Green A, McElroy WD (October 1956). "Function of adenosine triphosphate in the activation of luciferin". Arch. Biochem. Biophys. 64 (2): 257–71. doi:10.1016/0003-9861(56)90268-5. PMID 13363432.
- EC 18.104.22.168. ORENZA: a database of ORphan ENZyme Activities, accessed 27 November 2009.
- Shimomura O, Johnson FH (April 1975). "Chemical nature of bioluminescence systems in coelenterates". Proc. Natl. Acad. Sci. U.S.A. 72 (4): 1546–9. doi:10.1073/pnas.72.4.1546. PMC . PMID 236561.
- Dunlap, JC; Hastings, JW; Shimomura, O (1980). "Crossreactivity between the light-emitting systems of distantly related organisms: Novel type of light-emitting compound.". Proc. Natl. Acad. Sci. U.S.A. 77 (3): 1394–7. doi:10.1073/pnas.77.3.1394. PMC . PMID 16592787.
- "Major luciferin types". The Bioluminescence Web Page. University of California, Santa Barbara. 2009-01-09. Retrieved 2009-03-06.