Lucille was born Mahalia Lucille Jenkins in Bolton, Mississippi, the ninth child of Gertrude and Sherman Jenkins. Her mother died before she was five, and she was brought up by her father and her sisters. She started out singing gospel music,and was banned from listening to the blues. Nevertheless, she developed a liking for Bessie Smith, T-Bone Walker and other blues singers. She moved to Chicago in her teens, where she met Otis Spann whilst working as a barmaid. Soon she started working with him musically and later married him in 1969.
After Otis Spann's death in 1970, she continued singing, making recordings with Mighty Joe Young. She also participated in a festival dedicated to Otis Spann in September 10, 1972, featuring John Sinclair, Sun Ra, Freddie King, Luther Allison, Johnny Shines, Otis Rush and Sippie Wallace.
She released two singles in 1972, "Womans Lib" b/w "What You Do To Your Woman", and "Country Girl Returns" (parts 1 and 2). She also released an album Cry Before I Go in 1974.
- Rock, Doc. "The Dead Rock Stars Club 1994 - 1995". Enw.thedeadrockstarsclub.com. Retrieved 6 October 2018.
- Cry Before I Go - sleeve notes, 1974
- "Lucille Spann". All Music. All Media Network. Retrieved 9 April 2016.
- Wirz, Stefan. "Lucille Spann Discography". American Music. Stefan Wirz. Retrieved 10 April 2016.
- "Lucille Spann". Ancientfaces.ocm. Retrieved 6 October 2018.
- Eagle, Bob L.; LeBlanc, Eric S. (1 May 2013). "Blues: A Regional Experience". ABC-CLIO. p. 232. Retrieved 6 October 2018 – via Google Books.