|Duchess of Modena|
|Born||24 October 1628|
|Died||24 August 1699(aged 70)|
|Spouse||Francesco I d'Este, Duke of Modena|
|Rinaldo, Duke of Modena|
|Father||Taddeo Barberini, Prince of Palestrina|
Lucrezia Barberini (24 October 1628 – 24 August 1699) was an Italian noblewoman and, by marriage, Duchess of Modena. Born into the Barberini family, she was the last wife of Francesco I d'Este, Duke of Modena.
Barberini was born 24 October 1628; the eldest of five children to Taddeo Barberini, Prince of Palestrina and his wife Anna Colonna, a daughter of Filippo Colonna, Prince of Paliano. She was the sister of Maffeo Barberini and Cardinal Carlo Barberini and the Grand-Niece of Pope Urban VIII. Her uncles included three Cardinals; Francesco Barberini, Antonio Barberini and Girolamo Colonna.
On 14 October 1654 she married Francesco I d'Este, Duke of Modena and was the mother of Rinaldo d'Este who succeeded his father as Duke of Modena. The couple married in Loreto, Marche at the Basilica della Santa Casa. In many ways the marriage represented a long-overdue truce between the House of Este and the Barberini who had taken sides against each other during the First War of Castro. Francesco had, in fact, fought alongside his father against Taddeo Barberini's troops.
- Worldroots: Barberini
- Papal Genealogy: The Families And Descendants Of The Popes by George L. Williams (McFarland, 2004)
- Penny cyclopaedia of the Society for the diffusion of useful knowledge, Volume 3 (C. Knight, 1835)