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Lufenuron 200.svg
IUPAC name
Other names
U.S. EPA PC Code: 118205
103055-07-8 N
ATCvet code QP53BC01
ChEBI CHEBI:39384 YesY
ChEMBL ChEMBL1364906 N
ChemSpider 64813 YesY
Jmol-3D images Image
KEGG D08150 N
PubChem 71777
UNII 1R754M4918 YesY
Molar mass 511.15 g·mol−1
Melting point 174 °C (345 °F; 447 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

Lufenuron is the active ingredient in the veterinary flea control medication Program, and one of the two active ingredients in the flea, heartworm, and anthelmintic medicine milbemycin oxime/lufenuron (Sentinel).

Lufenuron is stored in the animal's body fat and transferred to adult fleas through the host's blood when they feed. Adult fleas transfer it to their growing eggs through their blood, and to hatched larvae feeding on her excrement. It does not kill adult fleas.

Lufenuron, a benzoylurea pesticide, inhibits the production of chitin in insects. Without chitin, a larval flea will never develop a hard outer shell (exoskeleton). With its inner organs exposed to air, the insect dies from dehydration soon after hatching or molting (shedding its old, smaller shell).

Lufenuron is also used to fight fungal infections, since fungus cell walls are about one third chitin.[citation needed]

Lufenuron is also sold as an agricultural pesticide for use against lepidopterans, eriophid mites, and western flower thrips. It is an effective antifungal in plants.

Because it is toxic to zooplankton,[1] Lufenuron was included in a biocide ban proposed by the Swedish Chemicals Agency. The ban was approved by the European Parliament on January 13, 2009.[2]


  1. ^ "Interpretation of criteria for approval of active substances in the proposed EU plant protection regulation". Swedish Chemicals Agency (KemI). 2008-09-23. Retrieved 2009-01-14. 
  2. ^ "MEPs approve pesticides legislation". 2009-01-13. Retrieved 2009-01-14. 

External Links[edit]

  • Lufenuron in the Pesticide Properties DataBase (PPDB)