Lugdunin

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Lugdunin
Lugdunin.svg
Names
IUPAC name
(1R,4R,7S,10R,13S,16R,19S)-7-(1H-Indol-3-ylmethyl)-10-isobutyl-4,13,16,19-tetraisopropyl-21-thia-3,6,9,12,15,18,23-heptaazabicyclo[18.2.1]tricosane-2,5,8,11,14,17-hexone
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
Properties
C40H62N8O6S
Molar mass 783.05 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Lugdunin is an investigational antibiotic, classified as a thiazolidine-containing cyclic peptide. It was isolated in 2016 after Staphylococcus lugdunensis was identified as the species of bacteria from the human nose that suppressed growth of species of disease-causing bacteria in that part of the human microbiome.[1][2][3]

Lugdunin is a non-ribosomally synthesized cyclic peptide that inhibits growth of Staphylococcus aureus strains. The lugdunin genes are located on a 30-kbp operon. The genes lugA, lugB, lugC, and lugD encode four non-ribosomal peptide synthases, which are preceded by a putative regulator gene lugR.[4]

Gene locustag protein size/aa Genbank protein entry RefSeq protein entry
lugR SLUG_RS03935 196 CCB53263.1 WP_002460032.1
lugA SLUG_RS03940 2374 CCB53264.1 WP_002478842.1
SLUG_RS03945 124 CCB53265.1 WP_002460029.1
lugB SLUG_RS03950 1230 CCB53266.1 WP_014533237.1
lugC SLUG_RS03955 2937 CCB53267.1 WP_002478844.1
lugT SLUG_RS03960 228 CCB53268.1 WP_002460022.1
lugD SLUG_RS03965 579 CCB53269.1 WP_002478846.1

References[edit]

  1. ^ Gallagher, James (2016-07-27). "Antibiotic resistance: 'Snot wars' study heralds new class of drugs". BBC News. Retrieved 2016-07-27. 
  2. ^ Zipperer, Alexander; Konnerth, Martin C.; Laux, Claudia; Berscheid, Anne; Janek, Daniela; Weidenmaier, Christopher; Burian, Marc; Schilling, Nadine A.; Slavetinsky, Christoph. "Human commensals producing a novel antibiotic impair pathogen colonization". Nature. 535 (7613): 511–516. doi:10.1038/nature18634. 
  3. ^ "Scientists find microbiotic treasure hidden in the nose". latimes.com. Los Angeles Times. Retrieved 2016-07-27. 
  4. ^ "Extended Data Figure 1: Gene cluster of lugdunin and generation of S. lugdunensis IVK28-Xyl". Nature. 535 (7613): 511–516. doi:10.1038/nature18634. Retrieved 2016-07-28. 

External links[edit]