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IUPAC name
3D model (JSmol)
Molar mass 783.05 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Lugdunin is an investigational antibiotic, classified as a thiazolidine-containing cyclic peptide. It was isolated in 2016 after Staphylococcus lugdunensis was identified as the species of bacteria from the human nose that suppressed growth of species of disease-causing bacteria in that part of the human microbiome.[1][2][3]

Lugdunin is a non-ribosomally synthesized cyclic peptide that inhibits growth of Staphylococcus aureus strains. The lugdunin genes are located on a 30-kbp operon. The genes lugA, lugB, lugC, and lugD encode four non-ribosomal peptide synthases, which are preceded by a putative regulator gene lugR.[4]

Gene locustag protein size/aa Genbank protein entry RefSeq protein entry
lugR SLUG_RS03935 196 CCB53263.1 WP_002460032.1
lugA SLUG_RS03940 2374 CCB53264.1 WP_002478842.1
SLUG_RS03945 124 CCB53265.1 WP_002460029.1
lugB SLUG_RS03950 1230 CCB53266.1 WP_014533237.1
lugC SLUG_RS03955 2937 CCB53267.1 WP_002478844.1
lugT SLUG_RS03960 228 CCB53268.1 WP_002460022.1
lugD SLUG_RS03965 579 CCB53269.1 WP_002478846.1


  1. ^ Gallagher, James (2016-07-27). "Antibiotic resistance: 'Snot wars' study heralds new class of drugs". BBC News. Retrieved 2016-07-27.
  2. ^ Zipperer, Alexander; Konnerth, Martin C.; Laux, Claudia; Berscheid, Anne; Janek, Daniela; Weidenmaier, Christopher; Burian, Marc; Schilling, Nadine A.; Slavetinsky, Christoph (2016). "Human commensals producing a novel antibiotic impair pathogen colonization". Nature. 535 (7613): 511–516. Bibcode:2016Natur.535..511Z. doi:10.1038/nature18634. PMID 27466123. S2CID 205249755.
  3. ^ "Scientists find microbiotic treasure hidden in the nose". Los Angeles Times. 2016-07-27. Retrieved 2016-07-27.
  4. ^ Krismer, Bernhard; Peschel, Andreas; Grond, Stephanie; Brötz-Oesterhelt, Heike; Schittek, Birgit; Kalbacher, Hubert; Willmann, Matthias; Marschal, Matthias; Slavetinsky, Christoph; Schilling, Nadine A.; Burian, Marc; Weidenmaier, Christopher; Janek, Daniela; Berscheid, Anne; Laux, Claudia; Konnerth, Martin C.; Zipperer, Alexander (July 2016). "Extended Data Figure 1: Gene cluster of lugdunin and generation of S. lugdunensis IVK28-Xyl". Nature. 535 (7613): 511–516. Bibcode:2016Natur.535..511Z. doi:10.1038/nature18634. PMID 27466123. S2CID 205249755.

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