Sartorius, a man of very traditional convictions, was the leader of a faction of the Moderate Party which, because of his Polish origin, was known as los polacos ("the Poles"). His newspaper, El Herlado, became one of the mainstays of the moderates during the regency of the ProgressivistBaldomero Espartero. During the Moderate decade (1844-1854), Sartorius held several political offices, such as Ministro de Gobernation, and became Prime Minister in 1853.
Sartorius was married to María de los Remedios Chacón y Romero de Cisneros (daughter of Rafael Chacón, 7th Marquis of Cela, and María del Amparo Romero de Cisneros y Nagüens), with whom he had seven children:
Doña Isabel Sartorius y Chacón (b. 1874), died unmarried and without issue.
Doña Laura Sartorius y Chacón, married to Enrique Maldonado y Carvajal, with issue.
Doña Leonor Sartorius y Chacón, died as an infant.
Don Luis Sartorius y Chacón, died as an infant.
Don José Sartorius y Chacón, died as an infant.
Doña María de la Concepción Sartorius y Chacón (1859-1887), married to Juan de Dios Pareja-Obregón, 7th Count of la Camorra, with issue.
Don Fernando Sartorius, 2nd Count of San Luis (1860-1920), married to María del Carmen Díaz de Mendoza y Aguayo, with issue.