Mangan owns and operates restaurants in Sydney Australia, at sea on P&O cruise ships and is the consulting chef for Virgin Australia Business Class. Mangan has his own line of gourmet products and is the co-founder of The Inspired Series and Australia’s Appetite for Excellence,, a hospitality awards program for young chefs, waiters and restaurateurs in Australia.
Mangan grew up in a family of seven boys in Melbourne. His culinary career began under the guide of Hermann Schneider at his Melbourne-based Two Faces restaurant. Following his training, Mangan persuaded Michel Roux at the 3 Michelin Star Waterside Inn London to take him on. Mangan moved to Sydney in 1994 to open John Hemmes’ CBD restaurant in CBD hotel, at age 24.
Mangan opened Salt with former business partner Lucy Allon in 1999, aged 29.
In 2005, Mangan sold 50% of the Salt brand to Port Japan Partners and opened Salt in Tokyo in 2005. The enterprise has grown to include Salt grill & Sky bar and Salt tapas & bar, Singapore; Salt, the adjoining World Wine Bar and Salt grill & tapas bar, Tokyo.
In August 2018, Mangan sold his remaining shares in the Asia Salt brand. The restaurants continue to operate without Mangan's involvement.
Having launched the Chicken Confidential fast food brand in 2017, as well as Luke’s Kitchen in Sydney’s Waterloo early 2018, the chef now plans to focus on rolling out a range of spin-off ventures under his first name, such as Luke’s Burger Bar, Luke’s Cafe, Luke’s Fish House, Luke’s Steak House and Luke’s Wine Bar, as well as maintaining his land, sea and air consultancies. Remaining under the brand is Salt grill, Luke's and A Taste of Salt on board five P&O cruise ships ;, Virgin Australia Business Class, the organic chicken burger restaurant at Chifley Plaza in Sydney CBD and Sydney International Airport, Coast Café + Bar and Bridge Bar, Sydney International Airport, Luke's Kitchen and glass brasserie.
Mangan's most recent venture includes the transformation of his wine and tapas bar MOJO on Danks Street in Waterloo into the neighbourhood eatery launched in February 2018.
Mangan also owns and operates Sydney CBD-based glass brasserie, which underwent a $6 million makeover in 2005 with New York architect Tony Chi heading interiors. In February 2018, glass underwent a $1.6 million kitchen refurbishment. 
Luke Mangan has published five books. 
In 2009, Mangan launched Luke Mangan Providores, a line of gourmet products that showcases Australian ingredients. The products includes spices like BBQ, Cajun, Dukkah, Za'atar, Curry and Morrocan, Extra Virgin Olive Oil and infusions like Garlic, Lemon, Lemon Myrtle and Truffle and Vinegars including Balsamic, White and Red Wine Vinegar. The range also includes mustards, relishes, pastes, sauces and chocolate-coated nuts. 
Mangan took a consultancy role for Virgin Atlantic, and went on to become the Virgin Australia Business Class consulting chef, providing guests with meals during their international and domestic Virgin Australia flights. 
Charity and industry work
Mangan supports Camp Quality, Newman’s Own Foundation, Cure The Future, Breast Cancer Network Australia, FSHD Global Research Foundation, and Australia's Biggest Morning Tea. In 2005, Mangan co-founded the Appetite for Excellence Awards program, which supports aspiring chefs, waiters and restaurateurs in Australia.
- "About the Awards Program Appetite for Excellence"
- Min Yan, "A Moment with ... Celebrity Chef Luke Mangan", LifestyleAsia, 15 Mar 2012
- Jones, Kate, "Luke Mangan finds the recipe to develop a food empire", The Age, 6 May 2013
- Guy Griffen, “glass brasserie” , Sydney Magazine, 18 October 2005
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- Shelley, Maureen. "Airlines roll out change of fare". Daily Telegraph. Retrieved 18 April 2013.
- "Archived copy". Archived from the original on 2013-05-04. Retrieved 2013-04-29.