Lumefantrine

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Lumefantrine
Lumefantrine.svg
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a609024
Routes of
administration
Oral
ATC code P01BF01 (WHO) (combination with artemether)
Legal status
Legal status
  • US: C
Identifiers
CAS Number 82186-77-4 N
PubChem (CID) 6437380
DrugBank DB06708 YesY
ChemSpider 4941944 YesY
UNII F38R0JR742 YesY
KEGG D03821 YesY
ChEBI CHEBI:156095 YesY
ChEMBL CHEMBL38827 YesY
Chemical and physical data
Formula C30H32Cl3NO
Molar mass 528.939 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Lumefantrine (or benflumetol) is an antimalarial drug. It is only used in combination with artemether. The term "co-artemether" is sometimes used to describe this combination.[1] Lumefantrine has a much longer half-life compared to artemether and so is therefore thought to clear any residual parasites that remain after combination treatment.[2]

Lumefantrine, along with pyronaridine and naphtoquine, were synthesized in course of the Project 523 antimalaria drug research initiated in 1967; these compounds are all used in combination antimalaria therapies.[3][4][5]

See also[edit]

References[edit]

  1. ^ Toovey S, Jamieson A, Nettleton G (2003). "Successful co-artemether (artemether-lumefantrine) clearance of falciparum malaria in a patient with severe cholera in Mozambique". Travel medicine and infectious disease. 1 (3): 177–9. doi:10.1016/j.tmaid.2003.09.002. PMID 17291911. 
  2. ^ White, Nicholas J.; van Vugt, Michele; Ezzet, Farkad (1999). "Clinical Pharmacokinetics and Pharmacodynamics of Artemether-Lumefantrine". Clinical Pharmacokinetics. 37 (2): 105–125. doi:10.2165/00003088-199937020-00002. ISSN 0312-5963. 
  3. ^ Cui, Liwang; Su, Xin-zhuan (2009). "Discovery, mechanisms of action and combination therapy of artemisinin". Expert Review of Anti-infective Therapy. 7 (8): 999–1013. doi:10.1586/eri.09.68. PMC 2778258Freely accessible. PMID 19803708. 
  4. ^ http://aac.asm.org/content/56/5/2465.full
  5. ^ Laman, M; Moore, BR; Benjamin, JM; Yadi, G; Bona, C; Warrel, J; Kattenberg, JH; Koleala, T; Manning, L; Kasian, B; Robinson, LJ; Sambale, N; Lorry, L; Karl, S; Davis, WA; Rosanas-Urgell, A; Mueller, I; Siba, PM; Betuela, I; Davis, TM (2014). "Artemisinin-naphthoquine versus artemether-lumefantrine for uncomplicated malaria in Papua New Guinean children: an open-label randomized trial". PLoS Med. 11: e1001773. doi:10.1371/journal.pmed.1001773. PMC 4280121Freely accessible. PMID 25549086.