Lupane is a rural, semi-arid area, which cultivates cotton and corn. A new university has been established under the name Lupane State University, which caters for the rest of Matebeleland North Province. The word Lupane is a Kalanga/Lozwi word.
The region has been explored for Coal Bed Methane (CBM) and a resource of over 370,000,000 cubic kilometres (13,000,000×10^12 cu ft) is thought to exist with a purity of 95% methane.
Lupane town is the main centre for the district and is the location of the Matebeleland North government head offices. It also houses the Provincial hospital (under construction).