Lupane is a rural, semi-arid area, which cultivates cotton and corn. A new university has been established under the name Lupane State University, which caters for the rest of Matebeleland North Province. The word Lupane is a Kalanga/Lozwi word.
Lupane town is the main centre for the district and is the location of the Matebeleland North government head offices. It also houses the Provincial hospital (under construction).
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