From Wikipedia, the free encyclopedia
  (Redirected from Lutopolar)
Jump to: navigation, search
Clinical data
  • X
ATC code
  • None
CAS Number
PubChem CID
ECHA InfoCard 100.007.545
Chemical and physical data
Formula C22H32O3
Molar mass 344.488 g/mol
3D model (JSmol)

Medroxyprogesterone (INN, BAN), also known as 17α-hydroxy-6α-methylprogesterone, and abbreviated as MP, is a steroidal progestin drug which was never marketed for use in humans.[1] A derivative, medroxyprogesterone acetate (MPA), is used as a medication.[2] Compared to MPA, MP is over two orders of magnitude less potent as a progestogen.[3] As such, MP itself is not used clinically, though it has seen limited use in veterinary medicine under the trade name Controlestril in France.[4] In addition, it is a metabolite of MPA.[5]

While medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone acetate,[2] what is normally being administered is MPA and not MP.[6]

See also[edit]


  1. ^ F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. p. 1079. ISBN 978-0-412-46630-4. Retrieved 28 May 2012. 
  2. ^ a b "MedroxyPROGESTERone: Drug Information Provided by Lexi-Comp". Merck Manual. 2009-12-01. Retrieved 2010-07-08. 
  3. ^ Pullen MA, Laping N, Edwards R, Bray J (September 2006). "Determination of conformational changes in the progesterone receptor using ELISA-like assays". Steroids. 71 (9): 792–8. PMID 16784762. doi:10.1016/j.steroids.2006.05.009. 
  4. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 638. ISBN 978-3-88763-075-1. Retrieved 28 May 2012. 
  5. ^ Ishihara M, Kirdani Y, Osawa Y, Sandberg AA (January 1976). "The metabolic fate of medroxyprogesterone acetate in the baboon". J. Steroid Biochem. 7 (1): 65–70. PMID 1271819. doi:10.1016/0022-4731(76)90167-9. 
  6. ^ Lenco W, Mcknight M, Macdonald AS (January 1975). "Effects of cortisone acetate, methylprednisolone and medroxyprogesterone on wound contracture and epithelization in rabbits". Ann. Surg. 181 (1): 67–73. PMC 1343717Freely accessible. PMID 1119869. doi:10.1097/00000658-197501000-00015.