Lymphocyte antigen 96

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LY96
Protein LY96 PDB 1T2Z.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LY96, ESOP-1, MD-2, MD2, ly-96, lymphocyte antigen 96
External IDs OMIM: 605243 MGI: 1341909 HomoloGene: 9109 GeneCards: LY96
RNA expression pattern
PBB GE LY96 206584 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001195797
NM_015364

NM_001159711
NM_016923

RefSeq (protein)

NP_001182726
NP_056179

NP_001153183.1
NP_058619.1
NP_001153183
NP_058619

Location (UCSC) Chr 8: 73.99 – 74.03 Mb Chr 1: 16.69 – 16.71 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Lymphocyte antigen 96, also known as "MD2," is a protein that in humans is encoded by the LY96 gene.[3][4][5]

The protein encoded by this gene is involved in binding lipopolysaccharide with TLR4.

Function[edit]

The MD-2 protein appears to associate with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccaride (LPS), thus providing a link between the receptor and LPS signaling.[5]

Interactions[edit]

Lymphocyte antigen 96 has been shown to interact with TLR 4.[3][6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K, Kimoto M (June 1999). "MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4". The Journal of Experimental Medicine. 189 (11): 1777–82. doi:10.1084/jem.189.11.1777. PMC 2193086Freely accessible. PMID 10359581. 
  4. ^ Abreu MT, Vora P, Faure E, Thomas LS, Arnold ET, Arditi M (August 2001). "Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide". Journal of Immunology. 167 (3): 1609–16. doi:10.4049/jimmunol.167.3.1609. PMID 11466383. 
  5. ^ a b "Entrez Gene: LY96 lymphocyte antigen 96". 
  6. ^ Re F, Strominger JL (June 2002). "Monomeric recombinant MD-2 binds toll-like receptor 4 tightly and confers lipopolysaccharide responsiveness". The Journal of Biological Chemistry. 277 (26): 23427–32. doi:10.1074/jbc.M202554200. PMID 11976338. 

Further reading[edit]

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

External links[edit]