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Classification and external resources
Specialty hematology
ICD-10 D72.8
ICD-9-CM 288.8
DiseasesDB 7677
MeSH D008231

Lymphocytopenia, or lymphopenia, is the condition of having an abnormally low level of lymphocytes in the blood. Lymphocytes are a white blood cell with important functions in the immune system. The opposite is lymphocytosis, which refers to an excessive level of lymphocytes.

Lymphocytopenia may be present as part of a pancytopenia, when the total numbers of all types of blood cells are reduced.


In some cases, lymphocytopenia can be further classified according to which kind of lymphocytes are reduced. If all three kinds of lymphocytes are suppressed, then the term is used without further qualification.

  • In T lymphocytopenia, there are too few T lymphocytes, but normal numbers of other lymphocytes. It causes, and manifests as, a T cell deficiency. This is usually caused by HIV infection (resulting in AIDS), but may be Idiopathic CD4+ lymphocytopenia (ICL), which is a very rare heterogeneous disorder defined by CD4+ T-cell counts below 300 cells/μL in the absence of any known immune deficiency condition, such as human immunodeficiency virus (HIV) infection or chemotherapy.[1]
  • In B lymphocytopenia, there are too few B lymphocytes, but possibly normal numbers of other lymphocytes. It causes, and manifests as, a humoral immune deficiency. This is usually caused by medications that suppress the immune system.
  • In NK lymphocytopenia, there are too few natural killer cells, but normal numbers of other lymphocytes. This is very rare.


The most common cause of temporary lymphocytopenia is a recent infection, such as the common cold.

Lymphocytopenia, but not idiopathic CD4+ lymphocytopenia, is associated with corticosteroid use, infections with HIV and other viral, bacterial, and fungal agents, malnutrition, systemic lupus erythematosus,[2] severe stress,[3] intense or prolonged physical exercise (due to cortisol release),[4] rheumatoid arthritis, sarcoidosis,[5] and iatrogenic (caused by other medical treatments) conditions.

Lymphocytopenia is a frequent, temporary result from many types of chemotherapy, such as with cytotoxic agents or immunosuppressive drugs. Some malignancies that have spread to involve the bone marrow, such as leukemia or advanced Hodgkin's disease,[6][7] also cause lymphocytopenia.

Another cause is infection with Influenza A virus subtype H1N1 (and other subtypes of the Influenza A virus) and is then often associated with Monocytosis;[8] H1N1 was responsible for the Spanish flu, the 2009 flu pandemic and in 2016 for the Influenza-epidemic in Brazil.[9]

Large doses of radiation, such as those involved with nuclear accidents or medical whole body radiation, may cause lymphocytopenia.


Lymphocytopenia is diagnosed when the complete blood count shows a lymphocyte count lower than the age-appropriate reference interval (for example, below 1.0 x 10(9)/L in an adult).


Lymphocytopenia that is caused by infections tends to resolve once the infection has cleared. Patients with idiopathic CD4+ lymphocytopenia may have either abnormally low but stable CD4+ cell counts, or abnormally low and progressively falling CD4+ cell counts; the latter condition is terminal.

Veterinary treatment[edit]

Lymphocytopenia caused by Feline Leukemia Virus and Feline immunodeficiency virus retroviral infections is treated with Lymphocyte T-Cell Immune Modulator.[10]


  1. ^ Malaspina A, Moir S, Chaitt DG, et al. (March 2007). "Idiopathic CD4+ T lymphocytopenia is associated with increases in immature/transitional B cells and serum levels of IL-7". Blood. 109 (5): 2086–8. doi:10.1182/blood-2006-06-031385. PMC 1801046Freely accessible. PMID 17053062. 
  2. ^ W L Ng; C M Chu; A K L Wu; V C C Cheng; K Y Yuen (2005). "Lymphopenia at presentation is associated with increased risk of infections in patients with systemic lupus erythematosus". Quarterly Journal of Medicine. 99 (1): 37–47. doi:10.1093/qjmed/hci155. PMID 16371405. 
  3. ^ Lymphocytopenia from the Merck Manual Home Health Handbook
  4. ^ Robson, PJ; Robson PJ; Blannin AK; Walsh NP; Castell LM; Gleeson M (1999). "Effects of exercise intensity, duration and recovery on in vitro neutrophil function in male athletes". International journal of sports medicine. Stuttgart: Thieme. 20 (2): 128–135. doi:10.1055/s-2007-971106. ISSN 0172-4622. PMID 10190775. 
  5. ^ Hedfors E, Holm G, Pettersson D (1974). "Lymphocyte subpopulations in sarcoidosis". Clinical and Experimental Immunology. 17 (2): 219–26. PMC 1554022Freely accessible. PMID 4549571. 
  6. ^ Faguet (1975). "Quantitation of immunocompetence in Hodgkin's disease". J Clin Invest. 56 (4): 951–957. doi:10.1172/JCI108175. PMC 301951Freely accessible. PMID 1159096. 
  7. ^ Weiss RB, Brunning RD, Kennedy BJ (1975). "Hodgkin's disease in the bone marrow". Cancer. 36 (6): 2077–83. doi:10.1002/cncr.2820360924. PMID 1203865. 
  8. ^ Merekoulias G, Alexopoulos EC, Belezos T, Panagiotopoulou E, Jelastopulu DM. "Lymphocyte to monocyte ratio as a screening tool for influenza". PLoS Curr. 2: RRN1154. doi:10.1371/currents.rrn1154. PMC 2847387Freely accessible. PMID 20383263. 
  9. ^ Over 1,000 Deaths from H1N1 Outbreak in Brazil (article from 12 July 2016)
  10. ^

External links[edit]