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M51 or M-51 may refer to:
- M-51 (Michigan highway), a state highway in Michigan
- M51 highway (Russia)
- M51 Skysweeper
- M51 MACI mine
- M51 SLBM, a French nuclear ballistic missile
- BMW M51, a 1991 straight-6 Diesel engine
- Sherman M-51, an Israeli modification of American M4 Sherman tank
- Eidgenössischer Stutzer 1851, a historical service rifle of the Swiss Army
- Messier 51, a spiral galaxy also known as the Whirlpool Galaxy
| disambiguation page lists articles associated with the same title formed as a letter-number combination.
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