M74 or M-74 may refer to:
- M74 mortar
- M74 motorway, a motorway in Scotland
- Messier 74, a spiral galaxy in the constellation Pisces
- M74 rocket, an incendiary rocket for a shoulder-fired M202A1 FLASH launcher
- M74 Tank Recovery Vehicle, a variant of the M4 Sherman tank
- M-74 (Michigan highway), a former state highway in Michigan
- M74 syndrome, a disease prevalent in Baltic salmon
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